A Liposomal Formulation for Improving Solubility and Oral Bioavailability of Nifedipine

Bi, Ye; Lv, Bingcong; Li, Lianlian; Lee, Robert J.; Xie, Jing; Qiu, Zhidong; Teng, Lirong

doi:10.3390/molecules25020338

Cited by 19 publications

(9 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These drug products leaves gastrointestinal tract (G.I.T) before the dissolution and originate inadequate ADME properties leading to reduced clinical effects and dosage escalation [5,6]. Various strategies have been investigated for solubility enhancement such as polymeric composites [7], polymeric nanoparticles [8], polymeric microneedles [9], polymeric microbeads [10], cocrystals [11], solid lipid nanoparticles (SLNs) [12], micelles [13], hydrogels [14], amorphous solid dispersions [12], liposome [15], nanosuspension [16], nanoemulsion, nanoplex [17],…”

Section: Introductionmentioning

confidence: 99%

Polyvinylpyrrolidone K-30-Based Crosslinked Fast Swelling Nanogels: An Impeccable Approach for Drug’s Solubility Improvement

Minhas

Khan

Sarfraz

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

Poor solubility is a global issue of copious pharmaceutical industries as large number of drugs in development stage as well as already marketed products are poorly soluble which results in low dissolution and ultimately dosage increase. Current study is aimed at developing a polyvinylpyrrolidone- (PVP-K30-) based nanogel delivery system for solubility enhancement of poorly soluble drug olanzapine (OLP), as solubilization enhancement is the most noteworthy application of nanosystems. Crosslinking polymerization with subsequent condensation technique was used for the synthesis of nanogels, a highly responsive polymeric networks in drug’s solubility. Developed nanogels were characterized by percent entrapment efficiency, sol-gel, percent swelling, percent drug loaded content (%DLC), percent porosity, stability, solubility, in vitro dissolution studies, FTIR, XRD, and SEM analysis. Furthermore, cytotoxicity study was conducted on rabbits to check the biocompatibility of the system. Particle size of nanogels was found with 178.99 ± 15.32 nm , and in vitro dissolution study exhibited that drug release properties were considerably enhanced as compared to the marketed formulation OLANZIA. The solubility studies indicated that solubility of OLP was noticeably improved up to 36.7-fold in phosphate buffer of pH 6.8. In vivo cytotoxicity study indicated that prepared PVP-K30-based formulation was biocompatible. On the basis of results obtained, the developed PVP-K30-co-poly (AMPS) nanogel delivery system is expected to be safe, effective, and cost-effective for solubility improvement of poorly soluble drugs.

show abstract

Section: Introductionmentioning

confidence: 99%

Polyvinylpyrrolidone K-30-Based Crosslinked Fast Swelling Nanogels: An Impeccable Approach for Drug’s Solubility Improvement

Minhas

Khan

Sarfraz

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…91 In addition, proliposome powder applications for oral applications are being investigated. 92,93 Nanoemulsions are considered an ideal alternative for the oral administration of drugs. Due to the emulsifier-based interface between oil and water, they provide high solubility capacity for both hydrophilic and hydrophobic drugs.…”

Section: Formulation Strategies Of Drugs For Oral Administrationmentioning

confidence: 99%

Nano Spray-Dried Drugs for Oral Administration: A Review

Öztürk

Arpagaus

2021

ASSAY and Drug Development Technologies

View full text Add to dashboard Cite

Spray drying is an important technology that is fast, simple, reproducible, and scalable. It has a wide application range, that is, in food, chemicals, and encapsulation of pharmaceuticals. The technology can be divided into conventional spray drying and nano spray drying. The key advantage of nano spray drying is the production of drug-loaded nanosized particles for various drug delivery applications. The recent developments in nano spray dryer technology and the market launch of the Nano Spray Dryer B-90 by Bu ¨chi Labortechnik AG in 2009 enabled the production of submicron spray-dried particles. This review focuses on nanosized drug delivery systems intended for oral administration produced by nano spray drying. First, the nano spray drying concept, the basic technologies implemented in the equipment, and the effects of the various process parameters on the final dry submicron powder properties are presented. Then, the topics of new formulation strategies of oral drugs are highlighted with examples that have entered the research literature in recent years. Next, the subjects of direct conversion of poorly watersoluble drugs, encapsulation of drugs, and drying of preformed nanoparticles are considered. Finally, topics such as morphology, particle size, size distribution, surface analysis, bioavailability, drug release, release kinetics, and solid-state characterization (by differential scanning calorimetry, X-ray diffraction, Fourier transform infrared spectroscopy, nuclear magnetic resonance) of oral drug delivery systems produced by nano spray drying are discussed. The review attempts to provide a comprehensive knowledge base with current literature and foresight to researchers working in the field of pharmaceutical technology and nanotechnology and especially in the field of nano spray drying.

show abstract

“…In assaying the effectiveness of nanoparticles in general, and of liposome in particular, size is one critical parameter among others. Normally, the nanoscale of a delivery structure will help it to avoid being taken up by the bodily mechanism and then be eliminated, and hence enable the carrier structure to establish its effectiveness in delivering drugs [28][29][30][31]. The same purpose is placed on the measuring of zeta potential: with the surface-modified liposomes, their ability to increase the circulation time in the bloodstream relies on the coating moieties [32,33].…”

Section: Particle Size and Zeta Potentialmentioning

confidence: 99%

Development, Characterization and In Vitro Evaluation of Paclitaxel and Anastrozole Co-Loaded Liposome

Vu¹,

Nguyen

et al. 2020

Processes

View full text Add to dashboard Cite

Paclitaxel (PTX) and anastrozole (ANA) have been frequently applied in breast cancer treatment. PTX is well-known for its anti-proliferative effect meanwhile ANA has just been discovered to act as an estrogen receptor α (ERα) ligand. The combination therapy of PTX and ANA is expected to improve treating efficiency, as ANA would act as a ligand binding with the ERα gene expressed in breast cancer cells and thereafter PTX would inhibit the division and cause death to those cancer cells. In this study, liposome-based nanocarriers (LP) were developed for co-encapsulation of PTX and ANA to improve the efficacy of the combined drugs in an Estrogen receptor-responsive breast cancer study. PTX-ANA co-loaded LP was prepared using thin lipid film hydration method and was characterized for morphology, size, zeta potential, drug encapsulation and in vitro drug release. In addition, cell proliferation (WST assay) and IN Cell Analyzer were used for in vitro cytotoxicity studies on a human breast cancer cell line (MCF-7). Results showed that the prepared LP and PTX-ANA-LP had spherical vesicles, with a mean particle size of 170.1 ± 13.5 nm and 189.0 ± 22.1 nm, respectively. Controlled and sustained releases were achieved at 72 h for both of the loaded drugs. The in vitro cytotoxicity study found that the combined drugs showed higher toxicity than each single drug separately. These results suggested a new approach to breast cancer treatment, consisting of the combination therapy of PTX and ANA in liposomes based on ER response.

show abstract

A Liposomal Formulation for Improving Solubility and Oral Bioavailability of Nifedipine

Cited by 19 publications

References 23 publications

Polyvinylpyrrolidone K-30-Based Crosslinked Fast Swelling Nanogels: An Impeccable Approach for Drug’s Solubility Improvement

Polyvinylpyrrolidone K-30-Based Crosslinked Fast Swelling Nanogels: An Impeccable Approach for Drug’s Solubility Improvement

Nano Spray-Dried Drugs for Oral Administration: A Review

Development, Characterization and In Vitro Evaluation of Paclitaxel and Anastrozole Co-Loaded Liposome

Contact Info

Product

Resources

About