Factors Influencing the Selection of Medium for Evaluating Drug Solubility and Dissolution in Bovine Milk

Abstract

Human drug delivery: Cow milk is a potential vehicle for delivering drugs to pediatric and geriatric patients (4-6). Therefore, the issue of drug solubility in milk, or its adsorption to milk proteins and fats, is relevant for both human and animal health. This led the USP to initiate an effort to define the composition of milk in normal and mastitic cattle and the variability that may exist across cow nutritional and health status.• Milk has been suggested as a component of fedstate simulated gastric fluids (SGFs) (7).