Impact of premature birth and critical illness on neonatal range of plasma amino acid concentrations determined by LC-MS/MS

Oladipo, Olajumoke; Weindel, Annette L.; Saunders, Al N.; Dietzen, Dennis J.

doi:10.1016/j.ymgme.2011.08.020

Cited by 45 publications

(43 citation statements)

References 8 publications

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“…A potential limitation of the study is the possible impact of unmeasured confounding on the relationship between category of prematurity and analyte levels. While we were able to explore the effects of factors such as sex, birth weight, timing of sample collection, receipt of transfusion, and feeding status, other potential confounders may have distorted the relationship between category of prematurity and analyte level (8,14,22). Therefore, the relationships we observed in this study are best interpreted as associations between analytes and prematurity, or factors associated with prematurity such as catabolism, immaturity of enzyme systems, and organ development.…”

Section: Metabolomics Of Prematuritymentioning

confidence: 85%

“…No trends were noted in the enzymes measured. Although differences in metabolic profile by degree of prematurity have been previously observed, this previous work has primarily focused on how GA may contribute to increased false-positive rates, with the goal of improving the precision of newborn screening in this population (8,9,14). In addition to this important objective, we propose that examining the specific analytes whose levels are influenced by prematurity 17-OhP, 17-hydroxyprogesterone; ALA, alanine; ARG, arginine; BIO, biotinidase; CIT, citruline; GALT, galactose 1 phosphate uridyl transferase; GLY, glycine; IRT, immunoreactive trypsinogen; LeU, leucine; MeT, methionine; ORN, ornithine; Pct diff, percent difference; Phe, phenylalanine; Std diff, standardized difference; TSh, thyrotropin-stimulating hormone; TYR, tyrosine; VAL, valine.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…One of these is gestational age (GA) at birth (8)(9)(10)(11). Prematurity may influence analyte levels through a variety of mechanisms, including increased catabolic stress, lessened maturation of metabolic pathways and/ or organ systems, and differential distribution of other confounding variables such as feeding status (9,12).…”

mentioning

confidence: 99%

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Metabolomics of prematurity: analysis of patterns of amino acids, enzymes, and endocrine markers by categories of gestational age

et al. 2013

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Background: Prematurity may influence the levels of amino acids, enzymes, and endocrine markers obtained through newborn screening. Identifying which analytes are the most affected by degree of prematurity could provide insight into how prematurity impacts metabolism. Methods: Analytes from blood spots assayed by Newborn Screening Ontario between March 2006 and April 2009 were used in this analysis. We examined the associations between the degree of prematurity and the levels of amino acids, enzymes, and endocrine markers in all newborns with and without adjustment for birth weight, feeding status, sample timing, transfusion, and sex. results: Our analysis included the following cohorts: 373,819 children born at term (>36 wk gestation), 26,483 near-term children (33-36 wk gestation), 4,354 very premature children (28-32 wk gestation), and 1,146 extremely premature children (<28 wk gestation). Of the amino acids showing consistent trends across categories of prematurity, the levels of three amino acids (arginine, leucine, and valine) were at least 50% different between the cohorts of extremely premature and term children. The levels of 17-hydroxyprogesterone increased with increasing prematurity, while thyrotropin-stimulating hormone values consistently decreased with increasing prematurity. None of the three enzyme markers we examined showed a trend in levels across categories of prematurity. conclusion: This study demonstrates that children at different stages of prematurity are metabolically distinct. Future research should focus on the mechanism by which specific analytes are influenced by prematurity.i n population-wide newborn screening, dried blood spot samples are obtained usually within 24-72 h of birth from which levels of various analytes are measured (1,2). In Ontario and several other jurisdictions, these analytes include markers of amino acid metabolism, fatty acid oxidation, and endocrine function (3-7). Analyte results are used to calculate risk for rare inborn errors of metabolism and endocrine disorders.Children having positive screening results are sent for confirmatory testing.It is generally recognized that, aside from the presence of a rare metabolic or endocrine disease, several other factors can affect the analytes measured for newborn screening. One of these is gestational age (GA) at birth (8-11). Prematurity may influence analyte levels through a variety of mechanisms, including increased catabolic stress, lessened maturation of metabolic pathways and/ or organ systems, and differential distribution of other confounding variables such as feeding status (9,12). Identifying which analytes are the most affected by extent of prematurity could provide insight into how prematurity influences metabolism.In Ontario, Canada, virtually every child undergoes newborn screening (13). Results for all analytes measured are stored along with key demographic variables. We examined the associations between different degrees of prematurity and subclinical levels of specific analytes, after removing screen...

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Section: Metabolomics Of Prematuritymentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Metabolomics of prematurity: analysis of patterns of amino acids, enzymes, and endocrine markers by categories of gestational age

et al. 2013

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“…Many factors common in NICUs such as prematurity, transfusion, the use of total parenteral nutrition, and carnitine supplementation could artificially increase or decrease the testing results. [35][36][37] The CLSI suggested serial specimen collection whereby a first specimen is collected on admission to the NICU and a repeat specimen would be obtained during 48 to 72 hours of life if the first specimen was collected within the first day; for preterm newborns and NICU-admitted newborns with positive results, a final specimen is collected either at 28 days or at discharge, whichever comes first. 38 Implementing the CLSI guidelines for premature newborns to interpret CAH screening results using the final specimen is very likely to yield different screening performance.…”

Section: Discussionmentioning

confidence: 99%

Damaged goods?: an empirical cohort study of blood specimens collected 12 to 23 hours after birth in newborn screening in California

Tang

Feuchtbaum

Neogi

et al. 2016

Genetics in Medicine

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Spectrum Analysis of Common Inherited Metabolic Diseases in Chinese Patients Screened and Diagnosed by Tandem Mass Spectrometry

Han

Feng

et al. 2014

J. Clin. Lab. Anal.

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Impact of premature birth and critical illness on neonatal range of plasma amino acid concentrations determined by LC-MS/MS

Cited by 45 publications

References 8 publications

Metabolomics of prematurity: analysis of patterns of amino acids, enzymes, and endocrine markers by categories of gestational age

Metabolomics of prematurity: analysis of patterns of amino acids, enzymes, and endocrine markers by categories of gestational age

Damaged goods?: an empirical cohort study of blood specimens collected 12 to 23 hours after birth in newborn screening in California

Spectrum Analysis of Common Inherited Metabolic Diseases in Chinese Patients Screened and Diagnosed by Tandem Mass Spectrometry

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