Impact of Prediagnosis Smoking, Alcohol, Obesity, and Insulin Resistance on Survival in Male Cancer Patients: National Health Insurance Corporation Study

Abstract

Prediagnosis risk factors for cancer development (smoking, alcohol consumption, obesity, and insulin resistance) had a statistically significant effect on survival among male cancer patients.

Insulin, glucose and the increased risk of cancer in patients with type 2 diabetes

“…This view is supported by large observational studies that have demonstrated a strong relationship between elevated blood glucose and cancer incidence and mortality rates [25,26]. The hyperglycaemia risk relationship appears to be consistent across all levels of blood glucose, even within the normoglycaemic range [25].…”

Smoking, alcohol and gastric cancer risk in Korean men: the National Health Insurance Corporation Study

“…The NHICS is a cohort investigation that was designed to assess the risk factors for the incidence of and mortality from cancer (Yun et al, 2005;Park et al, 2006). In brief, the cohort consisted of government employees, teachers and their dependents who were insured by the Korea National Health Insurance (NHI) Program in 1996, had at least one medical examination, and completed a selfadministered questionnaire.…”

Prevalence, Awareness, Control, and Treatment of Hypertension and Diabetes in Korean Cancer Survivors: A Cross-Sectional Analysis of the Fourth and Fifth Korea National Health and Nutrition Examination Surveys

“…With the increasing number of cancer survivors, evaluation and management of their chronic comorbid conditions have become important issues (Ogle et al, 2000). Hypertension is the most common comorbidity in cancer survivors, with a prevalence of 20%-65% (Ogle et al, 2000;Park et al, 2006;Shin et al, 2008;Braithwaite et al, 2009). Prevalence of hypertension at the time of cancer diagnosis is similar to that in the general population, however, the much higher rate is observed after treatment such as chemotherapy (Mouhayar et al, 2011).…”

“…Inadequately controlled comorbidities tend to adversely affect health status or disability as well as cancer treatment in cancer survivors, and they have prognostic significance in relation to survival disparity (Muss et al, 1992;Hewitt et al, 2003). Although hypertension and diabetes accounted for a poorer prognosis among cancer survivors in a limited number of studies on certain types of cancers, hypertension was associated with all-cause survival disparity and poor prognosis in stomach, lung, and colon cancer (Park et al, 2006;Shin et al, 2008;Braithwaite et al, 2009), and diabetes was significantly associated with higher mortality and recurrence rates in cancer survivors (Richardson et al, 2005;Griffiths et al, 2012). Therefore, proper management of hypertension and diabetes is important for better survival and quality of life for cancer survivors.…”