Insulin, glucose and the increased risk of cancer in patients with type 2 diabetes

Johnson, Jeffrey; Pollak, Michael

doi:10.1007/s00125-010-1855-0

Cited by 40 publications

(34 citation statements)

References 31 publications

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“…Although several mechanisms might be involved in the molecular link between glucose intolerance and the risk of developing cancer, Johnson and Pollak 31 recently commented that the accumulation of experimental and epidemiological evidence was more consistent with the hyperinsulinemia hypothesis and less so with the hyperglycemia hypothesis. It should be noted that our results also suggest that hyperinsulinemia, but not hyperglycemia, might promote the severity of NASH.…”

Section: Discussionmentioning

confidence: 99%

Impact of glucose tolerance on the severity of non-alcoholic steatohepatitis

Nakamura¹,

Yoneda

Fujita

et al. 2011

Journal of Diabetes Investigation

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Aims/Introduction: We investigated the relationship between non‐alcoholic steatohepatitis (NASH) and different stages of fasting plasma glucose (FPG) concentrations, and the association between factors related to glucose tolerance and severity of NASH.Materials and Methods: A total of 147 patients with non‐alcoholic fatty liver disease (NAFLD) who had undergone a liver biopsy were divided into three groups: a normal glucose tolerance (NGT) group, an impaired fasting glucose (IFG) group and a diabetes (DM) group. In addition, to investigate progression factors of NASH in the DM group, we divided the diabetic patients into two groups: a group with NASH (NASH group) and a group without NASH, the simple steatosis (SS) group. The relationship between the patients’ clinical parameters and the severity of NAFLD/NASH were analyzed.Results: In the patients with liver biopsies, the IFG group had the highest percentage of NASH. There was no correlation between FPG and either total NAFLD activity scores (NAS) or staging of NASH, but the fasting serum insulin was correlated significantly with both, even after adjusting for age, sex and body mass index. Among the diabetic patients, the fasting insulin values in the NASH group were significantly higher than in the SS group, but there were no differences in FPG or A1c values between the two groups. The fasting serum insulin correlated significantly with total NAS, but the FPG and A1c values did not.Conclusions: A high percentage of the IFG group developed NASH. Hyperinsulinemia, but not hyperglycemia, was associated with severity of NASH. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2011.00134.x, 2011)

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Section: Discussionmentioning

confidence: 99%

Impact of glucose tolerance on the severity of non-alcoholic steatohepatitis

Nakamura¹,

Yoneda

Fujita

et al. 2011

Journal of Diabetes Investigation

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“…Cancers are heterogeneous and insulin responsiveness is not universal, and for some tumours, proliferation may be enhanced by hyperglycaemia or inflammatory responses. However, the accumulation of experimental and epidemiological evidence is more consistent with the hyperinsulinaemia hypothesis, and less so with the hyperglycaemia hypothesis [43]. …”

Section: Potential Biological Mechanismsmentioning

confidence: 99%

Diabetes and cancer (1): evaluating the temporal relationship between type 2 diabetes and cancer incidence

et al. 2012

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Substantial evidence suggests that people with type 2 diabetes have an increased risk of developing several types of cancers. These associations may be due to a number of direct and indirect mechanisms. Observational studies of these associations, including the potential role for glucoselowering therapy, are being increasingly reported, but face a number of methodological challenges. This paper is the first of two review papers addressing methodological aspects underpinning the interpretations of links between diabetes and cancer, and suggests potential approaches to study designs to be considered in observational studies. This paper reviews factors related to cancer incidence in the diabetic population; the second paper relates to studies of cancer mortality.

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“…Thus, acromegalic patients with goitre should undergo periodic thyroid ultrasound examination. Type 2 DM, obesity, and overweight have been associated with an increased risk of malignancy [28][29][30]. However, there is little information concerning the occurrence of malignancy in acromegaly patients with or without DM as in our study.…”

Section: Discussionmentioning

confidence: 58%

Wpływ cukrzycy na przeżycie pacjentów z akromegalią

Chiou

Chen

Liu

et al. 2016

Endokrynologia Polska

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Introduction: An increased risk of mortality in patients with uncontrolled acromegaly has been reported in several studies. We aimed to assess the impact of co-morbidities on the survival of patients with acromegaly after long-term treatment and follow-up. Materials and methods: A retrospective analysis was performed for 285 patients with active acromegaly, who were admitted to the Chang Gung Memorial Hospital, Taiwan between 1978 and 2012. Of these patients, 106 (37.2%) were diagnosed with diabetes mellitus (DM). During the follow-up period, 21 cases of histological proved malignant in acromegalic patients, and DM with acromegaly had a higher incidence of malignancy (13.2% vs. 3.8%; p < 0.01). The 5-, 10-, and 20-year survival rates were 93.1%, 86.9%, and 84.7% for the DM group, respectively, and 96.5%, 96.5%, and 96.5% for the non-DM group, respectively. After a mean follow-up of 15.1 ± 0.6 years, age, DM, coronary heart disease, and malignancy were found to be significant factors of mortality. Control of growth hormone and IGF-1 levels also conferred a marginal survival benefit. Conclusions: DM and malignancy significantly influence the survival of patients with acromegaly; thus, these patients need close follow-up and appropriate therapy.

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Insulin, glucose and the increased risk of cancer in patients with type 2 diabetes

Cited by 40 publications

References 31 publications

Impact of glucose tolerance on the severity of non-alcoholic steatohepatitis

Impact of glucose tolerance on the severity of non-alcoholic steatohepatitis

Diabetes and cancer (1): evaluating the temporal relationship between type 2 diabetes and cancer incidence

Wpływ cukrzycy na przeżycie pacjentów z akromegalią

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