Impact of perioperative probiotic treatment for surgical site infections in patients with colorectal cancer

Aisu, Naoya; Tanimura, Syu; Yamashita, Yuichi; Yamashita, Kanefumi; Maki, Kenji; Yoshida, Yoichiro; Sasaki, Takuma; Takeno, Shinsuke; Hoshino, Seiichiro

doi:10.3892/etm.2015.2640

Cited by 63 publications

(69 citation statements)

References 24 publications

(22 reference statements)

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“…Aisu et al [63] studied the effect of perioperative probiotic supplementation on the postsurgery-related infectious complication in CRC patients (individuals with CRC stages I, II, IIIA, IIIB, and IV who are undergoing elective colorectal surgery). e supplementation of BIO-THREE ® (Enterococcus faecalis T110, Clostridium butyricum TO-A, and Bacillus mesentericus TO-A) to perioperative CRC patients for 3-15 days (before surgery) significantly reduced the postoperational superficial incisional surgical site infections compared to nonprobiotic group and also improved the microbiota and immune system positively [63]. Tan et al [64] examined the effect of perioperative probiotic (HEXBIO ® ) supplementation in promoting the recovery and returning to normal gut function in CRC patients (individuals with CRC stages I, II, III, and IV who are undergoing elective colorectal surgery).…”

Section: Clinical Trialsmentioning

confidence: 99%

The Role of Probiotics in Colorectal Cancer Management

Sivamaruthi

Kesika

Chaiyasut

2020

Evidence-Based Complementary and Alternative Medicine

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Colorectal cancer (CRC) is one of the most common cancerous diseases worldwide and causes leading cancer-associated deaths. Several factors are related to the incidence of CRC such as unhealthy diet and lifestyle, heredity, metabolic disorders, and genetic factors. Even though several advanced medical procedures are available for CRC treatment, the survival rates are poor with many adverse treatments associated side effects, which affects the quality of life. Probiotics are a well-known bioactive candidate for the treatment of several diseases and ill-health conditions. e recent scientific evidence suggested that probiotic supplementation protects the CRC patients from treatment-associated adverse effects. e manuscript summarizes the influence of probiotic supplementation on the health status of CRC patients and discusses the possible mechanism behind the protective effect of probiotics against CRC. e literature survey revealed that beneficial impact of probiotic supplementation depends on several factors such as strain, dosage, duration of the intervention, host physiology, and other food supplements. e probiotic intervention improves the microbiota, releases antimicrobials and anticarcinogenic agents, helps to remove carcinogens, and improves the intestinal permeability, tight junction function, and enzyme activity in CRC patients. Besides, not all probiotic strains exhibit anti-CRC activities; it is necessary to screen the potent strain for the development of a probiotic-based therapeutic agent to control or prevent the incidence of CRC.

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Section: Clinical Trialsmentioning

confidence: 99%

The Role of Probiotics in Colorectal Cancer Management

Sivamaruthi

Kesika

Chaiyasut

2020

Evidence-Based Complementary and Alternative Medicine

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“…In the study by Aisu et al (6), a total of 5 of 70 patients (7.1%) were positive for SSI when treated with probiotic, in contrast to the non-treated group where 16 of 65 patients (24.6%) presented infection (P=0.0081, 95% with confidence limit 0.8371). Other studies (5,18,19) showed a placebo response (OR =0.6928, P=0.1493, 95% CI, 0.4207 to 1.1409).…”

Section: Intake Of Probiotics and Incisional Infectionmentioning

confidence: 99%

“…Pitsouni et al (29) reported that the use of probiotics and symbiotics in patients submitted to CRC surgery is a very promising clinical measure for the prevention of postoperative infectious complications. However, it appears that the outcome of the treatment depends on the genus (2,(4)(5)(6)9,18,19 of bacteria, the number of bacteria administered and the number of viable probiotic bacteria that reach and colonize the colon (30).…”

Section: Cfu Lactobacillus Casei Andmentioning

confidence: 99%

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Probiotics as a preventive strategy for surgical infection in colorectal cancer patients: a systematic review and meta-analysis of randomized trials

Calaça¹,

Bezerra²,

Albuquerque³

et al. 2017

Transl. Gastroenterol. Hepatol.

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Background: Infection following abdominal surgery remains a major factor in morbidity among colorectal cancer (CRC) patients. Probiotic therapy has been suggested to improve the clinical and laboratory outcome of patients undergoing gastrointestinal surgery. The aim of this study was to investigate the efficacy of probiotic lactic acid bacteria in patients with CRC in the pre-and postoperative phases.Methods: Systematic database searches identified 1,080 related articles. However, only seven articles were selected according to the eligibility criteria for qualitative and quantitative evaluation.Results: Most of the reviewed articles presented satisfactory results related to the prevention of surgical inflammation in patients undergoing resection of CRC when using strains of Lactobacillus genus, predominantly.Conclusions: Probiotics are suggested to prevent surgical inflammation of CRC, at the same time that the combination of particular microorganisms administered is beneficial to the treatment and surgical recovery.

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“…(26) However, clinical studies show mixed results largely due to the heterogeneity of the administration schedules and the types of probiotics and synbiotics used. A recently performed systematic review with metanalysis of 28 randomized controlled trials involving 2511 patients revealed that the use of these substances has the potential to reduce the incidence of wound infections.…”

Section: Intestinal Microbiome and Surgical Site Infectionsmentioning

confidence: 99%

The role of the microbiota in surgical recovery

Krezalek

Alverdy²

2016

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review The purpose of this review is to highlight new research findings in the complex bidirectional crosstalk that occurs between the intestinal microbiome and the host immune system in the context of surgical recovery and outcomes. Recent findings Significant evidence has been generated emphasizing the central role of the intestinal microbiome on surgical outcomes such as wound healing, surgical site infections and anastomotic leak. Current preventive strategies including the use of some parenteral antibiotics, may actually exacerbate the problem by selecting for drug-resistant pathogens. Summary A delicate balance exists between the human host and its microbial counterparts that is directly related to post-surgical healing. This balance can be easily altered in favor of the pathogen through peri-operative and surgical interventions leading to intestinal dysbiosis and loss of colonization resistance. Current strategies to prevent infectious complications with the escalating use of broader and more powerful antibiotics is not an evolutionarily stable strategy. A more complete understanding of the ecological and molecular interactions of the host with its microbiome is necessary to uncover new therapeutic strategies that preserve the composition and function of the intestinal microbiome and constrain virulent pathogens through the course of surgical injury.

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Impact of perioperative probiotic treatment for surgical site infections in patients with colorectal cancer

Cited by 63 publications

References 24 publications

The Role of Probiotics in Colorectal Cancer Management

The Role of Probiotics in Colorectal Cancer Management

Probiotics as a preventive strategy for surgical infection in colorectal cancer patients: a systematic review and meta-analysis of randomized trials

The role of the microbiota in surgical recovery

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