Impact of periodontitis on chemokines in smokers

Haytural, O.; Yaman, Duygu; Ural, Ertan; Kantarcı, Alpdoğan; Demirel, Korkud

doi:10.1007/s00784-014-1314-2

Cited by 18 publications

(26 citation statements)

References 53 publications

(70 reference statements)

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“…10 Higher levels of MCP-1 in serum of smokers with periodontitis than nonsmokers with periodontitis have also been observed. 12 However, smoking status did not affect the association between MCP-1 polymorphism and chronic/aggressive periodontitis in this study. On the other hand, we included teeth extraction number as an independent variable and observed that the more teeth extracted during treatment, the better therapy results obtained.…”

Section: Discussioncontrasting

confidence: 60%

See 1 more Smart Citation

Association between monocyte chemoattractant protein-1 -2518 A/G gene polymorphism and the outcome of the nonsurgical periodontal treatment

Chang

Lin

et al. 2018

Journal of the Formosan Medical Association

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Section: Discussioncontrasting

confidence: 60%

“…Haytural et al have detected higher MCP-1 levels in serum in smokers with periodontitis than nonsmokers with periodontitis. 12 Smoking might have some effects on MCP-1 levels related to pathogenesis of periodontitis.…”

Section: Introductionmentioning

confidence: 99%

Association between monocyte chemoattractant protein-1 -2518 A/G gene polymorphism and the outcome of the nonsurgical periodontal treatment

Chang

Lin

et al. 2018

Journal of the Formosan Medical Association

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“…Seven studies did not report anything about mean pack/year of cigarette smoking . This also might have resulted in bias with regards to the GCF cytokine/chemokine levels, which remains consistent with smoking status …”

Section: Discussionmentioning

confidence: 96%

Effect of scaling and root planing on gingival crevicular fluid cytokine/chemokine levels in smokers with chronic periodontitis: A systematic review

Eshghipour

Tofighi

Nehal

et al. 2018

J of Invest & Clin Dent

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In the present study, the impact of scaling and root planing (SRP) on gingival crevicular fluid (GCF) cytokine/chemokine levels in smokers with chronic periodontitis was assessed. The PICO (population, intervention, comparison, outcome) question was: In smokers with chronic periodontitis (population), what is the effect of SRP (intervention) in comparison to SRP in non-smokers with chronic periodontitis (comparison) on the GCF cytokine/chemokine level (outcome)? Indexed databases were searched up to September 2017. Of 4330 titles, nine studies reporting the levels of 13 different cytokines/chemokines were included. Eight studies had a moderate risk of bias, while one study had a high risk of bias. Almost all cytokines/chemokines were pro-inflammatory cytokines. Five cytokines/chemokines studied in four clinical studies were decreased in the smoker-chronic periodontitis group following SRP. One study observed that the GCF levels of interleukin-17 increased, while anti-inflammatory osteoprotegerin was reduced in both the SCP and non-smoker-chronic periodontitis groups at follow up. However, the majority of cytokines/chemokines did not change in the SCP groups at follow up. The current weight of evidence is not sufficient to prove that SRP has an impact on GCF cytokine/chemokine profile in smokers with chronic periodontitis. Evaluation of wide panels of pro-inflammatory cytokines/chemokines related to collagen degradation and alveolar bone destruction in future studies are warranted.

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“…As importantly, the literature is replete with publications demonstrating differences in host factors (Eren et al 2015, Winning et al 2015, Lutfioglu et al 2016) and oral microbes (Shchipkova et al 2010, Bizzarro et al 2013 in smokers compared to non-smokers. However, it is important to recognize disease variation within the smoking population, and thus critical to delineate the unique biological features of health and disease in the smoking population (Eren et al 2015, Haytural et al 2015. The present study applies an ensemble classification framework (SVA: selectivevoting ensemble classification approach) , Nagarajan & Upreti 2016 for discerning the biology of periodontitis and non-periodontitis populations, while providing insights into potential variations within the periodontitis population.…”

Section: Conflict Of Interest and Source Of Funding Statementmentioning

confidence: 99%

“…, Haytural et al. ). The present study applies an ensemble classification framework ( SVA : selective‐voting ensemble classification approach) (Nagarajan et al.…”

mentioning

confidence: 99%

Integrated biomarker profiling of smokers with periodontitis

Nagarajan

Al‐Sabbagh

Dawson

et al. 2017

J Clinic Periodontology

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In the context of precision medicine, understanding patient-specific variation is an important step in developing targeted and patient-tailored treatment regimens for periodontitis. While several studies have successfully demonstrated the usefulness of molecular expression profiling in conjunction with single classifier systems in discerning distinct disease groups, the majority of these studies do not provide sufficient insights into potential variations within the disease groups. Aim The goal of the present study is to discern biological response profiles of periodontitis and non-periodontitis smoking subjects using an informed panel of biomarkers across multiple scales (salivary, oral microbiome, pathogens and other markers). Materials and Methods The investigation uses a novel ensemble classification approach (SVA-SVM) to differentiate disease groups and patient-specific biological variation of systemic inflammatory mediators and IgG antibody to oral commensal and pathogenic bacteria within the groups. Results Sensitivity of SVA-SVM is shown to be considerably higher than several traditional independent classifier systems. Patient-specific networks generated from SVA-SVM are also shown to reveal cross-talk between biomarkers in discerning the disease groups. High-confidence classifiers in these network abstractions comprised of host responses to microbial infection elucidated their critical role in discerning the disease groups. Conclusions Host adaptive immune responses to the oral colonization/infection contribute significantly to creating the profiles specific for periodontitis patients with potential to assist in defining patient-specific risk profiles and tailored interventions.

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Impact of periodontitis on chemokines in smokers

Abstract: Understanding the local and systemic chemokine responses in smokers will enable the development of biologically-based treatment methods for chronic periodontitis.

Cited by 18 publications

References 53 publications

Association between monocyte chemoattractant protein-1 -2518 A/G gene polymorphism and the outcome of the nonsurgical periodontal treatment

Association between monocyte chemoattractant protein-1 -2518 A/G gene polymorphism and the outcome of the nonsurgical periodontal treatment

Effect of scaling and root planing on gingival crevicular fluid cytokine/chemokine levels in smokers with chronic periodontitis: A systematic review

Integrated biomarker profiling of smokers with periodontitis

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