Association between monocyte chemoattractant protein-1 -2518 A/G gene polymorphism and the outcome of the nonsurgical periodontal treatment

Chang, Ching Wen; Lin, Hung Hsin; Wu, Shih Yun; Wu, Ching; Lai, Yung‐Lien; Hung, Shan Ling

doi:10.1016/j.jfma.2017.03.013

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…Furthermore, the majority of previous studies that aimed to examine the effect of susceptibility to chronic periodontitis on the treatment outcome following non-surgical periodontal therapy have shown similar results ( 23 ). Matrix metalloproteinase (MMP)-1, MMP-13, IL-1, IL-4, IL-6, IL-8, mannose-binding lectin (MBL) and monocyte chemoattractant protein (MCP)-1 gene polymorphisms have been analyzed ( 23 , 27 ). These short-term studies demonstrated no significant differences between genetic polymorphisms of the IL-8, MMP-13, MMP-1, IL-1, IL4, IL-8, MBL genes and response to non-surgical periodontal treatment ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

“…More specifically, Caucasian, African/Caribbean and Asian patients were included in the same analysis rather than a specific ethnic group and the effect of genotype on periodontal treatment outcome was determined based on the decrease in the number of pockets rather than the evaluation of any continuous periodontal parameters. In addition, a Taiwanese study demonstrated that MCP-1 -2518 A/G genotype was significantly associated with the treatment outcome of non-surgical periodontal treatment as determined by evaluation of the probing depth, gingival index and bleeding index ( 27 ). However, this gene polymorphism influenced the treatment outcome only in patients with a diagnosis of aggressive periodontitis rather than in patients with chronic periodontitis.…”

Section: Discussionmentioning

confidence: 99%

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Interleukin-6 and Interleukin-10 Gene Polymorphisms in Patients with Chronic Periodontitis and Response to Treatment after 3 Years

Chatzopoulos¹,

Doufexi²,

Zarenti³

et al. 2020

Acta Stomatol Croat

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Objective The aim of this study was to investigate whether genetic susceptibility to chronic periodontitis, conferred by the presence of the IL-6 -572GG genotype or the IL-10 -592A allele, influences the outcomes following a non-surgical periodontal therapy (NSPT)over a long period of time. Material and methods Thirty-seven chronic periodontitis patients were divided into two groups according to genotype as susceptible (SCP) and non-susceptible (NSCP). All subjects were clinically evaluated at baseline and 3 years following NSPT. Blood samples were collected at baseline from the individuals who fulfilled the inclusion criteria. All participants received NSPT from a single periodontist who was blind to the genotype status of each patient. A statistical analysis was performed by comparing the variables between groups using the Mann-Whitney U test and between baseline and 3 years for each group using the Wilcoxon test. Results The mean age of the population was estimated to be 47.68±8.64 years and it included 51.4% females, 48.6% smokers, and 45.9% alcohol consumers. Following a genetic analysis, 70.3% of patients were homozygous carriers of the IL-6 -572G (IL-6 SCP), and 46.0% of them were carriers of the IL-10 -592A allele (IL-10 SCP). NSPT reduced all studied parameters (probing depth, attachment loss, bleeding on probing, percentage of sites with 4-6mm and ≥7mm pocket depth and attachment loss) to all participants, but the treatment outcome was not associated with the genotype. The SCP and NSCP individuals showed similar clinical parameters at baseline and at 3 years. Conclusions Within the limitations of this 3-year prospective cohort study in Caucasians diagnosed with chronic periodontitis, individuals susceptible to periodontal disease as determined by the presence of the IL-6 -572GG genotype or the IL-10 -592A allele showed similar treatment outcome following NSPT.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Interleukin-6 and Interleukin-10 Gene Polymorphisms in Patients with Chronic Periodontitis and Response to Treatment after 3 Years

Chatzopoulos¹,

Doufexi²,

Zarenti³

et al. 2020

Acta Stomatol Croat

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“…The MCP-1-2518 A/G genotype predicted poor treatment response in GI, BI, and PD improvement, whereas MCP-1-2518 A/A genotype predicted better treatment outcome in BI and PD improvement. 65…”

Section: Nonsurgical Treatmentmentioning

confidence: 99%

Aggressive Periodontitis Etiology, Pathophysiology, and Treatment: A Recent Review

Missoum¹

2019

International Journal of Experimental Dental Science

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Periodontitis is a microbially driven inflammatory disorder that affects the periodontium and continues to be a major dental health problem worldwide. The aggressive form, formerly known as juvenile periodontitis, is a pathological condition in which rapid destruction of the periodontal tissues and bone occurs at youth, resulting in loss of teeth. Factors such as lifestyle, host response genetic defects, and subgingival microbial consortium are responsible for the progression of the disease. This devastating loss of face esthetics and oral function affects younger patients emotionally, mostly adolescents, and requires costly and invasive treatments such as implants. Fortunately, recent discoveries regarding early diagnostic tools and biomarkers were proven to be effective in controlling aggressive periodontitis (AgP) progression and limiting it at its early stages. Other modified therapies such as bone augmentation and flap surgery has also ameliorated dental clinical parameters and minimized the necessity for dental implants. Each periodontal treatment is assigned depending on the stage and the severity of the disease, and for this reason, early management is crucial. This was achievable, thanks to novel diagnostic methods such as advanced cone-beam computed tomography (CBCT) imaging and high throughput analysis of gingival crevicular fluid (GCF) biomarkers. The review discusses and compares the latest case studies on the use of different periodontal therapies to treat AgP. Recent research about its pathogenesis and etiological factors such as microbial and genetic association is also highlighted.

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Kao¹

2018

Journal of the Formosan Medical Association

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Association between monocyte chemoattractant protein-1 -2518 A/G gene polymorphism and the outcome of the nonsurgical periodontal treatment

Cited by 5 publications

References 38 publications

Interleukin-6 and Interleukin-10 Gene Polymorphisms in Patients with Chronic Periodontitis and Response to Treatment after 3 Years

Interleukin-6 and Interleukin-10 Gene Polymorphisms in Patients with Chronic Periodontitis and Response to Treatment after 3 Years

Aggressive Periodontitis Etiology, Pathophysiology, and Treatment: A Recent Review

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