Impact of Pediatric Rome III Criteria of Functional Dyspepsia on the Diagnostic Yield of Upper Endoscopy and Predictors for a Positive Endoscopic Finding

Tam, Yuk Him; Chan, Kin Wai; To, Ka Fai; Cheung, Siu Tim; Mou, Jennifer Wai Cheung; Pang, Kristine Kit Yi; Wong, Yin Cheong; Sihoe, Jennifer Dart Yin; Lee, Kim Hung

doi:10.1097/mpg.0b013e31820e2026

Cited by 29 publications

(36 citation statements)

References 21 publications

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“…Seventy-five children showed no significant gastric pathology. Nevertheless, the "non-significant findings" were described by the pathologists as descriptive changes such as: reactive mucosal changes and mild chronic inflammatory cell infiltrates (mild gastritis) [15]. The long term prognosis and the clinical significance of those "nonsignificant findings" in children have not been elucidated.…”

Section: Prevalence Of Hp-negative Gastritis (Idiopathic)mentioning

confidence: 99%

“…Nonetheless, even in those reports, the specific analysis of Hp-negative gastritis was not the main topic of the discussion [12][13][14]. In a recent prospective study, a Chinese group assessed the endoscopic findings of children diagnosed with functional abdominal pain [15]. Only patients who were positive by Rome 3 criteria were included.…”

Section: Prevalence Of Hp-negative Gastritis (Idiopathic)mentioning

confidence: 99%

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Helicobacter-pylori Negative Gastritis in Children—A New Clinical Enigma

Elitsur

Preston

2014

Diseases

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Abstract:The decrease in the prevalence of Helicobacter pylori (Hp) infection in children in the world gave rise to a new pathological finding termed as Hp-negative gastritis. Unfortunately, the term "Hp-negative gastritis" has not been identified as a pathological process and has the status of a "second cousin"; in most publications it was never mentioned as a subject to be dealt with, but was "left over" data that was never the topic of the manuscripts' discussions. Only recently has the topic captured the attention of the pathologists who described this phenomenon in adults, yet the pathological and/or clinical spectrum or significance of this phenomenon has not been adequately investigated. In the current manuscript we describe Hp-negative gastritis in children, summarize its clinical prevalence and touch upon the possible etiology, pathology, and/or therapeutic implication. Overall, this review has concluded that Hp-negative gastritis is a pathological phenomenon in children that needs further investigation, and to date, as the title suggests, is a new clinical enigma that needs to be considered.

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Section: Prevalence Of Hp-negative Gastritis (Idiopathic)mentioning

confidence: 99%

Section: Prevalence Of Hp-negative Gastritis (Idiopathic)mentioning

confidence: 99%

Helicobacter-pylori Negative Gastritis in Children—A New Clinical Enigma

Elitsur

Preston

2014

Diseases

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“…It has been estimated that approximately one-third are undernourished and many exhibit the consequences of malnutrition 7 . Yet, the prevalence and severity of malnutrition increases in parallel with the duration and severity of neurological impairment 95,96,97 .…”

Section: Feeding and Nutritional Aspectsmentioning

confidence: 99%

“…Despite its benign nature the persistence of symptoms can result in significant stress to children and their families as well as clinicians concerned at the possibility of missing an underlying pathology. With the implementation of the Rome III criteria, abdominal pain-related FGID, have been framed as a positive diagnosis rather than one of exclusion 3 , which will hopefully facilitate the reduction of unnecessary diagnostic procedures and expedite the initiation of appropriate treatment 7 .…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal and nutritional problems in neurologically impaired children

Quitadamo

Thapar

Staiano

et al. 2016

European Journal of Paediatric Neurology

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Fax: + 44 20 7813 8382Gut Motility disorders comprise a heterogeneous group of disorders that result from disruption of the functional integrity of the intrinsic neuromusculature of the gastrointestinal (GI) tract. This intrinsic neuromusculature includes the smooth muscle layers, the intrinsic nervous system of the GI tract (enteric nervous system or ENS) and the interstitial cells of Cajal. The contribution of each of these components to function can be compromised by alterations in structure (ranging from absence to derangement in numbers and/or anatomy) or of function (complete or partial failure in physiological function). This pathology can be primary or secondary to a number of insults e.g. infections, inflammation, toxins etc. In children disorders may be congenital being present from birth or acquired later in life. Finally involvement of the enteric neuromusculature can be patchy/segmental or affect the gastrointestinal tract diffusely.Neuro-gastroenterology is the study of the interface of all aspects of the gastrointestinal tract or digestive system with the different branches of the body's nervous system including the enteric, central and autonomic nervous systems. The combined terms 'Neurogastroenterology and motility' are designed to encompass the study of all the components of the enteric neuromuscualture and their modulating influences and represents one of the fastest growing areas in gastroenterology clinical practice and research. This chapter aims to address some of the most common neurogastroenterology and motility conditions seen in clinical practice ranging from those with defined pathology to those which fall under the umbrella of functional gastrointestinal disorders. The latter comprise some of the commonest but challenging disorders and the term 'functional' reflects the fact that in the majority of such conditions no organic cause can be found. It should also be noted that at the present time many functional disorders e.g. abdominal pain-related functional GI disorders, represent symptom complexes that can further be subdivided into more discrete entities e.g. irritable bowel syndrome, functional abdominal pain etc depending on the nature, location and associations of the symptoms. Clinicians will often rely on the presence or absence of 'red flags' e.g. associated weight loss, severe or significant symptoms etc to decide whether patients are likely to have organic or functional disorders. Exhaustive investigations in the latter are likely to prove fruitless, expensive and perpetuate 'illness behaviours' in the patients. Abdominal pain-related functional gastrointestinal disorders IntroductionAbdominal pain-related functional gastrointestinal disorders (FGID) constitute a spectrum of conditions characterised by the presence of recurrent abdominal pain in the absence of any defined pathology 1 . In the past these disorders fell under the single term 'Recurrent abdominal pain' (RAP) but have since been recategorised under an international initiative (Rome Foundation) to improve the dia...

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“…Sus indicaciones vienen delimitadas por los criterios de organicidad propuestos hace diez años por Chelimsky y Czinn 8 (Tabla 1), y que sirvieron como punto de partida para los criterios Roma III 9 . Estos criterios han mostrado ser una herramienta efectiva a la hora de discriminar pacientes con organicidad manifiesta 10 . A través de la endoscopia digestiva alta se podrá obtener biopsias para examen histológico y para hacer el test de la ureasa 11 .…”

Section: Hallazgos Endoscópicos Más Frecuentesunclassified

Patogenia y expresión endoscópica de la infección por H. pylori en niños

Aguado

Izquierdo

Garriga³

et al. 2012

Rev Pediatr Aten Primaria

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La infección por Helicobacter pylori es una de las causas más frecuentes de infección bacteriana cróni-ca en el ser humano. A través de distintos factores patogénicos (adhesinas, ureasa, proteínas citotóxicas cagA y vacA) puede producir cambios que se pueden apreciar en una endoscopia digestiva alta. Estos incluyen la aparición de lesiones ulcerosas, mucosa en empedrado y palidez alternando con eritema, entre otros. Sus dianas preferentes en la edad pediátrica son el antro gástrico y el duodeno proximal. Este artículo hace una revisión de los hallazgos endoscópicos relacionados con la infección por H. pylori en niños, así como de sus posibles causas y consecuencias clínicas.H. pylori infection is one of the most frequent chronic bacterial infections in human beings. Through different pathogenic factors (adhesins, urease, cagA and vacA cytotoxic proteins) it may produce mucosal changes that can be seen in an upper gastrointestinal endoscopy. These changes include, among others, ulcerative lesions, cobblestone mucosa and pallor alternating with erythema. Its favorite targets in children are the gastric antrum and proximal duodenum. This article reviews the endoscopic findings related to H. pylori infection in children and their possible causes and clinical consequences. INTRODUCCIÓNMucho se ha hablado, se habla y se hablará sobre la infección por Helicobacter pylori. Esta bacteria gram negativa microaerofílica puede presumir de contar con una revista científica íntegramente dedicada a ella. Su amplia extensión es determinante. De hecho, es una de las causas más frecuentes de infección bacteriana crónica en el ser humano 1 . En España, siguiendo un modelo de distribución propio de países desarrollados, se estima que la prevalencia en niños en edad escolar está en torno al 20-25% 2 . La edad media de adquisición de la infección, si extrapolamos los datos fiables de un estudio reciente en la población portuguesa, está en torno a los seis años y medio El presente artículo supone una puesta al día ilustrada sobre los hallazgos endoscópicos derivados de la mencionada infección, siempre dentro del marco de la edad pediátrica.

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Impact of Pediatric Rome III Criteria of Functional Dyspepsia on the Diagnostic Yield of Upper Endoscopy and Predictors for a Positive Endoscopic Finding

Abstract: Rome III recommendations of screening dyspeptic children for alarm features and investigation for H pylori are effective to identify children who have a higher likelihood of organic diseases and require upper endoscopy before making a diagnosis of FD.

Cited by 29 publications

References 21 publications

Helicobacter-pylori Negative Gastritis in Children—A New Clinical Enigma

Helicobacter-pylori Negative Gastritis in Children—A New Clinical Enigma

Gastrointestinal and nutritional problems in neurologically impaired children

Patogenia y expresión endoscópica de la infección por H. pylori en niños

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