Helicobacter-pylori Negative Gastritis in Children—A New Clinical Enigma

Elitsur, Yoram; Preston, Deborah L.

doi:10.3390/diseases2040301

Cited by 3 publications

(3 citation statements)

References 25 publications

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“… 13 , 14 This is significantly higher than that reported in children in the USA (3%–7%). 15 We also found a higher prevalence (60.7%) of gastritis without H. pylori than observed previously in children from Turkey (40%), Mexico (44%), and the USA (50%). 7 – 9 Studies in adults have shown a much lower proportion of Hp− gastritis.…”

Section: Discussionsupporting

confidence: 62%

Lymphoid follicles in children with <em>Helicobacter pylori</em>-negative gastritis

Broide

Richter

Mendlovic

et al. 2017

CEG

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PurposeThe prevalence of Helicobacter pylori gastritis has been declining, whereas H. pylori-negative gastritis has become more common. We evaluated chronic gastritis in children with regard to H. pylori status and celiac disease (CD).Patients and methodsDemographic, clinical, endoscopic, and histologic features of children who underwent elective esophagogastroduodenoscopy were reviewed retrospectively. Gastric biopsies from the antrum and corpus of the stomach were graded using the Updated Sydney System. H. pylori presence was defined by hematoxylin and eosin, Giemsa, or immunohistochemical staining and urease testing.ResultsA total of 184 children (61.9% female) met the study criteria with a mean age of 10 years. A total of 122 (66.3%) patients had chronic gastritis; 74 (60.7%) were H. pylori-negative. Children with H. pylori-negative gastritis were younger (p=0.003), were less likely to present with abdominal pain (p=0.02), and were mostly of non-Arabic origin (p=0.011). Nodular gastritis was found to be less prevalent in H. pylori-negative gastritis (6.8%) compared with H. pylori-positive gastritis (35.4%, p<0.001). The grade of mononuclear infiltrates and neutrophil density was more severe in the H. pylori-positive group (p<0.001). Pan-gastritis and lymphoid follicles were associated most commonly with H. pylori. Although less typical, lymphoid follicles were demonstrated in 51.3% of H. pylori-negative patients. The presence or absence of CD was not associated with histologic findings in H. pylori-negative gastritis.ConclusionOur findings suggest that lymphoid follicles are a feature of H. pylori-negative gastritis in children independent of their CD status.

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Section: Discussionsupporting

confidence: 62%

Lymphoid follicles in children with <em>Helicobacter pylori</em>-negative gastritis

Broide

Richter

Mendlovic

et al. 2017

CEG

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“…The prevalence of H pylori ‐negative gastritis in pediatric EGDs has previously been reported to be between 37% and 94%. Available studies have usually included all gastritides and/or gastroparesis, not just chronic forms as is the case in our study (3,4,21,22). The focus of previous studies has been mainly on H pylori ‐positive gastritides with report of H pylori‐negative findings (23,24).…”

Section: Discussionmentioning

confidence: 99%

“…Although still widespread in developing countries, H pylori is becoming rare in developed countries. Simultaneously, the finding of H pylorinegative chronic gastritis (HPNCG) appears to be increasing (3,4).…”

mentioning

confidence: 99%

Prevalence and Clinical Significance of Helicobacter Pylori‐negative Chronic Gastritis in Children

Virkkula

Kivelä

Hiltunen

et al. 2022

J. pediatr. gastroenterol. nutr.

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Objectives: The clinical significance of Helicobacter pylori-negative chronic gastritis (HPNCG) in children is unclear. We examined this issue in patients who had undergone esophagogastroduodenoscopy with systematic gastric sampling. Methods: Data of 1178 consecutive children who underwent diagnostic esophagogastroduodenoscopy were collected. Baseline characteristics and long-term outcomes were compared between children with active and inactive HPNCG and those with normal gastric histology. Follow-up data were available for up to 13 years. Results: Altogether 24 (2.0%) children had active and 235 (19.9%) inactive HPNCG, 27 (2.3%) were Hpylori-positive, 46 (3.9%) had other gastric pathology, and 846 (71.8%) normal histology. Diarrhea (31.3% vs 25.1%, P ¼ 0.033), poor growth (23.6% vs 14.7%, P < 0.001), bloody stools (13.9% vs 7.2%, P < 0.001), anemia (46.5% vs 23.4%, P < 0.001), hypersedimentation (39.7% vs 21.4%, P < 0.001), hypoalbuminemia (40.4% vs 16.2%, P < 0.001), and elevated fecal calprotectin (62.4% vs 31.5%, P < 0.001) were more common and heartburn (13.9% vs 22.9%, P ¼ 0.002) less common in the HPNCG group than in the controls. Both active (OR 3.64,95% CI 1.35-9.82) andinactive (2.98, 2.18-4.08) HPNCG predicted a diagnosis in the initial investigations. Crohn disease (41.7%) was the most common diagnosis in active HPNCG and celiac disease (37.4%) in inactive HPNCG. During follow-up, 7 (9.9%) of the 71 initially nondiagnosed HPNCG children received a diagnosis. Conclusions: HPNCG is a frequent finding in children undergoing EGD, the active form being associated especially with Crohn disease and the inactive with celiac disease. The long-term prognosis of patients with HPNCG who do not receive an initial diagnosis is good.

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Prevalence and Associated Risk Factors of Helicobacter pylori Negative Gastritis

Roland¹,

Lee²,

Salem³

et al. 2016

J Gastrointest Dig Syst

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Helicobacter-pylori Negative Gastritis in Children—A New Clinical Enigma

Cited by 3 publications

References 25 publications

Lymphoid follicles in children with <em>Helicobacter pylori</em>-negative gastritis

Lymphoid follicles in children with <em>Helicobacter pylori</em>-negative gastritis

Prevalence and Clinical Significance of Helicobacter Pylori‐negative Chronic Gastritis in Children

Prevalence and Associated Risk Factors of Helicobacter pylori Negative Gastritis

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