Lymphoid follicles in children with <em>Helicobacter pylori</em>-negative gastritis

Abstract

PurposeThe prevalence of Helicobacter pylori gastritis has been declining, whereas H. pylori-negative gastritis has become more common. We evaluated chronic gastritis in children with regard to H. pylori status and celiac disease (CD).Patients and methodsDemographic, clinical, endoscopic, and histologic features of children who underwent elective esophagogastroduodenoscopy were reviewed retrospectively. Gastric biopsies from the antrum and corpus of the stomach were graded using the Updated Sydney System. H. pylori presence was defined by hematoxylin and eosin, Giemsa, or immunohistochemical staining and urease testing.ResultsA total of 184 children (61.9% female) met the study criteria with a mean age of 10 years. A total of 122 (66.3%) patients had chronic gastritis; 74 (60.7%) were H. pylori-negative. Children with H. pylori-negative gastritis were younger (p=0.003), were less likely to present with abdominal pain (p=0.02), and were mostly of non-Arabic origin (p=0.011). Nodular gastritis was found to be less prevalent in H. pylori-negative gastritis (6.8%) compared with H. pylori-positive gastritis (35.4%, p<0.001). The grade of mononuclear infiltrates and neutrophil density was more severe in the H. pylori-positive group (p<0.001). Pan-gastritis and lymphoid follicles were associated most commonly with H. pylori. Although less typical, lymphoid follicles were demonstrated in 51.3% of H. pylori-negative patients. The presence or absence of CD was not associated with histologic findings in H. pylori-negative gastritis.ConclusionOur findings suggest that lymphoid follicles are a feature of H. pylori-negative gastritis in children independent of their CD status.

Ultrasonographic indices of skin changes in children with Helicobacter pylori-associated gastroduodenitis combined with food allergy

“…The thickness of the epidermis depended on the study area, the patient's age, it was higher compared to the control group, and in children with H. pylori-associated CGD in combination with FA it was 1.06 ± 0.01 mm, the mean echogenicity was 136.87 ± 1.79 units. According to the literature, the thickness of the epidermis in healthy children varies from 0.03 to 1.00 mm 13 . The epidermis was a thickened hyperechoic strip in most children with H. pylori-associated CGD in combination with FA.…”

“…According to the literature, the thickness of the dermis of the unchanged skin varies from 0.50 to 4.00 mm 13 . In our study, in children with H. pylori-associated CGD in combination with FA, the derma was visualized in the form of strips with increased thickness, decreased echogenicity (the range of variation from 21.00 to 46.00 units.…”

“…In the structure of diseases of the gastrointestinal tract in children CGD takes up 45-55% [4][5][6][7][8][9] . The incidence of CGD associated with Helicobacter pylori (H. pylori) infection varies according to the age of the child, being 20% in children aged 4-9 years, 40% in children aged between 10-14 years, and 52-70% in children over 15 years and adults [10][11][12][13] . The prevalence of FA among children ranges from 12.0 to 37.0%, which is significantly higher than in adults [14][15][16][17] .…”

Helicobacter Pylori infection in children: A 10-year single center experience

“…Helicobacter pylori (H. pylori), dünyada en sık görülen enfeksiyon etkenlerinden birisidir. Hastalığın prevalansı ülkeler arasında ve aynı ülkenin farklı bölgelerinde değişiklik göstermekle birlikte dünya nüfusunun yarısından fazlasında enfeksiyona neden olmaktadır (1)(2)(3)(4) . Gelişmekte olan ülkelerde H. pylori, sıklıkla çocukluk çağında kazanılmakta ve hem gelişmiş hem de gelişmekte olan ülkelerde prevalansı yaş ile artmaktadır (1,5) .…”

Helicobacter pyloriand some aspects of gut microbiota in children

“…The CD20‐B cell‐specific differentiation antigen demonstrated the most pronounced increase and may play an important role in the development of lymphoid hyperplasia and NG. Broide et al valuated chronic gastritis in children with regard to H. pylori infection and celiac disease. In total, 122/184 (66.3%) children had chronic gastritis, and 74/122 (60.7%) were H. pylori negative.…”