Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double‐blind placebo‐controlled study

Huurre, Anu; Laitinen, Kirsi; Rautava, Samuli; Korkeamäki, Mika; Isolauri, Erika

doi:10.1111/j.1365-2222.2008.03008.x

Cited by 192 publications

(181 citation statements)

References 43 publications

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“…This may be due to strain and host specific characteristics. However, a recent study with a combination of Lactobacillus rhamnosus (L. rhamnosus) GG and B. lactis Bb-12, achieved for the first time, a reduction in risk of both eczema and later sensitization, but only in a high-risk population [21] . Nevertheless, we need to acknowledge that a more profound understanding of the complex nature of atopy and atopic disease is needed, as it is likely that there are distinct etiological factors and pathogenetic mechanisms underlying the heterogeneous manifestations of the disorder.…”

mentioning

confidence: 99%

Specific probiotics alleviate allergic rhinitis during the birch pollen season

Ouwehand¹,

Nermes²,

Collado³

et al. 2009

WJG

113

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AIM:To investigate whether birch pollen allergy symptoms are linked with gut microbiota changes and whether probiotics have an effect on these. METHODS:Forty seven children with confirmed birch pollen allergy were randomized to receive either a probiotic combination of Lactobacillus acidophilus (L . a c i d o p h i l u s ) N C F M T M ( ATC C 7 0 0 3 9 6 ) a n dBifidobacterium lactis (B. lactis ) Bl-04 (ATCC SD5219) or placebo in a double-blind manner for 4 mo, starting prior to onset of the birch pollen season. Symptoms were recorded in a diary. Blood samples were taken for analysis of cytokines and eosinophils. Fecal samples were analysed for microbiota components, calprotectin and IgA. Nasal swabs were taken for analysis of eosinophils. RESULTS:The pollen season induced a reduction in Bifidobacterium , Clostridium and Bacteroides which could not be prevented by the probiotic intervention. During the intervention, significantly higher numbers of B. lactis 11.2 × 10 7 ± 4.2 × 10 7 vs 0.1 × 10 7 ± 0.1 × 10 7 bacteria/g feces (P < 0.0001) and L. acidophilus NCFM TM 3.5 × 10 6 ± 1.3 × 10 6 vs 0.2 × 10 6 ± 0.1 × 10 6 bacteria/g feces (P < 0.0001) were observed in the probiotic group compared to the placebo group. During May, there was a tendency for fewer subjects, (76.2% vs 95.2%, P = 0.078) to report runny nose, while during June, fewer subjects, 11.1% vs 33.3%, reported nasal blocking in the probiotics group (P = 0.101). Concomitantly, fewer subjects in the probiotic group had infiltration of eosinophils in the nasal mucosa compared to the placebo group, 57.1% vs 95% (P = 0.013). Eye symptoms tended to be slightly more frequent in the probiotic group, 12.5 d[interquartile range (IQR) 6-18] vs 7.5 d (IQR 0-11.5) (P = 0.066) during May. Fecal IgA was increased in the placebo group during the pollen season; this increase was prevented by the probiotics (P = 0.028). CONCLUSION:Birch pollen allergy was shown to be associated with changes in fecal microbiota composition. The specific combination of probiotics used was shown to prevent the pollen-induced infiltration of eosinophils into the nasal mucosa, and indicated a trend for reduced nasal symptoms.

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mentioning

confidence: 99%

Specific probiotics alleviate allergic rhinitis during the birch pollen season

Ouwehand¹,

Nermes²,

Collado³

et al. 2009

WJG

113

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“…Lactobacillus acidophilus strain was not able to produce same result in a different study suggesting the strain specificity [128]. Lactobacillus GG in combination with B. lactis during pregnancy and breastfeeding reduced the risk of atopic eczema and allergic sensitization in child [129], whereas a mixture of probiotics (Lactobacillus GG, L. rhamnosus LC705, B. breve, and Propionibacterium freudenreichii ssp. Shermanii JS) failed to reduce the risk atopic eczema [130], indicates the strain differences and interactions.…”

Section: Probiotics and Allergy And Immune Responsementioning

confidence: 91%

Probiotics: Mechanisms of Action and Clinical Applications

Gogineni¹,

Morrow²,

Malesker³

2013

J Prob Health

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Probiotics are living microorganisms which when taken in adequate amount provides benefit to the host. While this beneficial effect was originally thought to stem from improvements in the intestinal microbial balance, there is now substantial evidence that probiotics can also provide benefits by modulating immune functions. Extrapolation of immunomodulatory effects found in the laboratory and in animal studies with outcomes in human trials presents a difficult challenge. Not all probiotics are created equal and the benefits are strain and dose specific. With newer strain-specific clinical trials and meta-analysis of the clinical trials, the beneficial role of probiotics in certain diseases has been evolving. Some uncertainity still exists with probiotics in other diseases with regard to the therapeutic role, strain-specificity, dosage and duration. Identification of clinical characteristics of effective probiotic strains, their mechanisms of action and testing of probiotic-based treatment may provide the true beneficial effect of probiotics in various disorders.

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“…За последние 10 лет опубликовано достаточно много результатов клинических исследований, посвященных пробиотикам и их эффектам при аллер-гических заболеваниях [7][8][9][10][11][12][13][14][15][16][17][18]. В табл.…”

Section: терапевтическая эффективность пробиотиков у детей с аллерголunclassified

Immunomodulatory and Therapeutic Activity of Bifido- And Lactobacteria in Children With Allergic Diseases and Frequent Respiratory Tract Infections

Хорошилова¹

2013

Vopr. sovr. pediatr.

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Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double‐blind placebo‐controlled study

Cited by 192 publications

References 43 publications

Specific probiotics alleviate allergic rhinitis during the birch pollen season

Specific probiotics alleviate allergic rhinitis during the birch pollen season

Probiotics: Mechanisms of Action and Clinical Applications

Immunomodulatory and Therapeutic Activity of Bifido- And Lactobacteria in Children With Allergic Diseases and Frequent Respiratory Tract Infections

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