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Multiple micronutrient deficiency (simultaneous insufficient supply of the organism with several vitamins at once (vitamin D, B group), as well as calcium, magnesium, zinc and iodine, and not an isolated deficiency of any one micronutrient is characteristic of a significant part of the Russian population throughout the year, regardless of places of residence. The growing need of the organism at different periods of life (puberty, pregnancy, breastfeeding, aging), various diseases, drug therapy, the period of convalescence, stress, the use of various diets, enrichment of the diet with polyunsaturated fatty acids and dietary fiber, religious observance, adverse environmental factors further increase the risk of multiple micronutrient deficiencies. Micronutrients (vitamins and essential minerals) are closely interconnected into complex metabolic networks, which provide maintaining homeostasis and health. Deficiency of each of the essential micronutrients is a risk factor for the development of a particular disease, and simultaneous multiple micronutrient deficiency creates a “causality network” of not just one, but several diseases at once. Conversely, an adequate or optimal sufficiency of the body with all micronutrients, respectively, creates a “network of conditions ensuring the prevention of the disease”, due to the full implementation of all processes dependent on them in the body. This means that replenishing inadequate food intake of scarce micronutrients is an important way to maintain health and longevity. Given the variety of vitamin-mineral supplements, it is important to choose the right supplement. The maximum effectiveness to maintain the body’s vitamin and mineral status at the optimum level will be ensured by the intake of not individual micronutrients, but vitamin and mineral supplements containing a complete set of vitamins in doses close to the physiological needs of the body and basic minerals (calcium, magnesium, zinc and iodine), the deficit of which is characteristic for the Russian population.
Multiple micronutrient deficiency (simultaneous insufficient supply of the organism with several vitamins at once (vitamin D, B group), as well as calcium, magnesium, zinc and iodine, and not an isolated deficiency of any one micronutrient is characteristic of a significant part of the Russian population throughout the year, regardless of places of residence. The growing need of the organism at different periods of life (puberty, pregnancy, breastfeeding, aging), various diseases, drug therapy, the period of convalescence, stress, the use of various diets, enrichment of the diet with polyunsaturated fatty acids and dietary fiber, religious observance, adverse environmental factors further increase the risk of multiple micronutrient deficiencies. Micronutrients (vitamins and essential minerals) are closely interconnected into complex metabolic networks, which provide maintaining homeostasis and health. Deficiency of each of the essential micronutrients is a risk factor for the development of a particular disease, and simultaneous multiple micronutrient deficiency creates a “causality network” of not just one, but several diseases at once. Conversely, an adequate or optimal sufficiency of the body with all micronutrients, respectively, creates a “network of conditions ensuring the prevention of the disease”, due to the full implementation of all processes dependent on them in the body. This means that replenishing inadequate food intake of scarce micronutrients is an important way to maintain health and longevity. Given the variety of vitamin-mineral supplements, it is important to choose the right supplement. The maximum effectiveness to maintain the body’s vitamin and mineral status at the optimum level will be ensured by the intake of not individual micronutrients, but vitamin and mineral supplements containing a complete set of vitamins in doses close to the physiological needs of the body and basic minerals (calcium, magnesium, zinc and iodine), the deficit of which is characteristic for the Russian population.
Introduction. The role of disturbance of the intestinal microbiota in the development of diseases of infectious genesis and the possibility of using probiotics as an immunomodulatory agent are confirmed by the evidence base of numerous studies.Purpose. To study the results of using a multi-strain immunoprobiotic from the first days of acute respiratory infection as an emergency prevention, for the purpose of reducing the duration and severity of the disease.Materials and methods.Children from 2 to 10 years old took part in the clinical observation: the main group (45 children) received a multi-strain immunoprobiotic in accordance with the instructions for use for 1 week, starting from the 1–2 day of acute respiratory infection and the comparison group (37 children) who did not receive an immunoprobiotic.Results and discussion. As a result of the study, the effectiveness and safety of the use of an immuno-probiotic in children of preschool and primary school age, when prescribed from the first days of acute respiratory infection, and its positive effect on the course of the disease were shown. The duration of the disease in patients receiving the immunoprobiotic was statistically significantly less, and the severity of the disease was milder than in the comparison group. The incidence of repeated respiratory infections during one month after discontinuation in the main observation group was 3.1 times lower than in the comparison group. At the end of the experiment, statistically significantly higher levels of leukocytes, eosinophils, monocytes and the absolute number of lymphocytes were revealed in the comparison group that did not receive the immunoprobiotic.Conclusions. The obtained results allowed to substantiate the use of a multi-strain immuno-probiotic as a non-specific immunomodulatory agent for emergency prevention when prescribed from the first days of a respiratory infection for the purpose to reduce the duration and severity of the disease.
ДвНЗ «Тернопільський державний медичний університет імені І.Я. Горбачевського мОЗ України» У статті проаналізовано актуальні аспекти щодо дисбіозу товстої кишки у клінічній практиці і можливостей його фармакологічної корекції препаратами пре-і пробіотичного спектра. Ключові слова: дисбіоз товстої кишки, пробіотики, пребіотики, персоніфікований підхід до лікування.
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