Impact of herpes zoster and postherpetic neuralgia on the quality of life of Germans aged 50 or above

Curran, Desmond; Schmidt-Ott, Ruprecht; Schutter, Ulf; Simon, Jörg; Anastassopoulou, Anastassia; Matthews, Sean

doi:10.1186/s12879-018-3395-z

Cited by 46 publications

(41 citation statements)

References 44 publications

(50 reference statements)

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“…In our study, pain intensity had a both direct and indirect negative effect on QoL of patients with NeP, which meant with an increase in pain intensity, the QoL would decrease and this result was consistent with many previous studies (Cocchio et al, ; Curran et al, ; Melek et al, ). More importantly, our participants were composed of four kinds of disease‐causing NeP, which may exemplify pain more accurately than a specific disease‐causing NeP, a common trend in previous studies.…”

Section: Discussionsupporting

confidence: 92%

Depression as a mediator of quality of life in patients with neuropathic pain: A cross‐sectional study

Liu

2019

Journal of Advanced Nursing

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Aims To explore whether pain intensity has an indirect effect on quality of life through mediation of depression in patients with neuropathic pain (NeP). Design An observational, questionnaire‐based, cross‐sectional study. Methods A convenience sample of patients suffering from NeP were enrolled from June 2015 ‐ May 2016. Three questionnaires were used to collect data of pain intensity, Quality of life and depression. Andrew Hayes' PROCESS macro modelling tool for the SPSS software, based on the mediation Bootstrap confidence interval method, was used to analyse the mediation effect. Results Both pain intensity and depression correlated negatively with the quality of life of patients. The indirect effect of pain intensity on the quality of life through depression was negative. Conclusions Increased pain intensity and depression were associated with a decreased quality of life in patients suffering from NeP and pain intensity had an indirect effect on the quality of life of patients through depression. Impact A low quality of life and depression are commonly seen in patients with NeP. However, little is known about the relationship between pain, quality of life and depression. Both pain intensity and depression had some negative effect on quality of life in patients with NeP. Pain intensity had an indirect effect on quality of life through a mediation effect of depression in patients with NeP. When caring for patients with NeP, nurses should assess depression routinely and try to alleviate it.

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Section: Discussionsupporting

confidence: 92%

Depression as a mediator of quality of life in patients with neuropathic pain: A cross‐sectional study

Liu

2019

Journal of Advanced Nursing

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“…Questionnaire compliance (in terms of response rates for completed questionnaires) in this study was lower than observed for other studies which used a similar approach to evaluating HZ impact on HRQL [25,26]. We had available ZBPI and EQ-5D scores for only around 50% of our cohort at initial assessment, and so our observations on pain and interference in ADLs and impact on HRQL may not be wholly representative of the overall study population.…”

Section: Discussionmentioning

confidence: 70%

“…Data on the severity of HZ pain and impact upon activities of daily living (ADL) and HRQL were collected through questionnaires as reported in similar previous studies in patients with HZ from international studies and in those conducted in Germany, Italy, and Japan [24][25][26][27] which used the validated Zoster Brief Pain Inventory (ZBPI) and the EuroQoL-5 Dimension (EQ-5D) questionnaires [4,7,28,29]. For assessment of subsequent pain, clinically relevant PHN was defined as the presence of HZassociated moderate or severe ''worst pain'' score C 3 on the ZBPI scale index persisting or appearing more than 90 days after onset of the rash [25][26][27]30].…”

Section: Data Collection and Patient Follow-upmentioning

confidence: 99%

Economic Burden and Impact on Quality of Life of Herpes Zoster in Spanish Adults Aged 50 Years or Older: A Prospective Cohort Study

Díez‐Domingo

Curran

Cambronero³

et al. 2021

Adv Ther

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Introduction:The economic burden of herpes zoster (HZ), including its most common complication, postherpetic neuralgia (PHN), and its impact on health-related quality of life (HRQL) is not well described in Spain. The aim of this study was to estimate HZ-related healthcare costs and impact on HRQL in Spanish adults aged 50 years or older. Methods: A prospective, observational study was performed with patients with HZ recruited through four general practitioner networks in Spain (NCT01521286). HRQL data were collected using the EuroQoL-5 Dimension (EQ-5D) questionnaire; HZ-related pain and associated interference with activities of daily living (ADL) were assessed using the Zoster Brief Pain Inventory (ZBPI) questionnaire at days 0 (HZ rash onset), 15, 30, 60, and 90; patients with PHN were assessed up until day 270. Medical resource utilization was recorded throughout study follow-up. Work loss for patients/caregivers was also assessed. Costs were calculated from both the payer and societal perspectives. Results: A total of 545 patients with Hz were included, of whom 25 developed PHN. During days 0-30 post HZ diagnosis, the mean EQ-5D utility score was 0.738, equating to a utility loss of 0.138. Sleep was the ADL most affected component. The mean costs for HZ in the overall cohort were €240 and €296 from the payer/societal perspective, respectively; €187/ €242 for patients with HZ without any HZ-related complications; and €571/€712 for patients who developed PHN. The majority of costs were incurred during days 0-30. Conclusions: In Spain, HZ and HZ-related complications such as PHN reduce patient HRQL and increase the economic burden for both payers and society in general. Trail Registration: ClinicalTrials.gov identifier NCT01521286.

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“…PHN was defined as the presence of pain with NRS-11 ≥ 3 after 90 days of rash onset. A patient with pain intensity of NRS-11 < 3 or a patient whose treatment was terminated owing to pain disappearance was defined as non-PHN (19). Any complication that occurred within 3 months was recorded.…”

Section: Data Collection and Outcomesmentioning

confidence: 99%

Delayed Initiation of Supplemental Pain Management is Associated with Postherpetic Neuralgia: A Retrospective Study

Yan

2020

Pain Phys

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Background: Acute pain is a risk factor for developing postherpetic neuralgia (PHN), the most common complication of herpes zoster (HZ). Supplemental analgesics are frequently used in the treatment of acute herpetic pain. However, there are insufficient data regarding when to begin supplemental analgesics, and it is unknown whether the delayed use of supplemental analgesics increases the risk of PHN in high-risk patients. Objectives: This study aimed to evaluate the association between initial time of supplemental pain management and the risk of PHN in high-risk patients. Study Design: Retrospective study. Setting: The Department of Anesthesiology and Pain Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine. Methods: We performed a retrospective study between May 13, 2017 and August 8, 2018 in our clinic. Multivariable logistic regression analysis was conducted to examine the independent factors associated with PHN. Supplemental pain management was defined as any use of opioids, tricyclic antidepressants, or nerve blocks. A subgroup analysis was conducted in patients who received supplemental pain management within the first 30 days of onset. According to the initial time of supplemental pain management, patients were divided into 2 groups: the early treatment group (≤ 14 days), and the late treatment group (> 14 days). The clinical outcomes in these 2 groups was compared for propensity score (PS) matching. Results: A total of 134 patients with HZ aged 50 years or older with moderate to severe pain were enrolled in this study. The delayed initiation of supplemental pain management (> 14 days) (odds ratio, 4.11; 95% confidence interval, 1.69-9.92; P = 0.002) and severity of rash (odds ratio, 2.93; 95% confidence interval, 1.22-7.01; P = 0.016) were independent factors associated with PHN. In the subgroup analysis, after PS matching, there were no significant differences in the baseline clinical parameters between the early and late treatment groups. The incidence of PHN was significantly lower in the early treatment group than the late treatment group (36. 4% vs. 72.7%; P = 0.015). Reduction in pain was also greater in the early treatment group. Limitations: The findings identified in the present study are specific to the patients who were relatively older and with moderate to severe pain. It is impossible to determine from our study whether younger individuals and individuals with mild acute pain will benefit from early supplemental treatments. Furthermore, because of the retrospective nature of the study, there may be some confounders that could not be controlled. Further prospective studies with larger sample sizes and longer follow-up periods are needed. Conclusions: The early use of supplemental pain management may decrease the risk of PHN. It might therefore be beneficial to consider administering supplemental pain management earlier in older patients with moderate to severe acute herpetic pain. Key words: Herpes zoster, postherpetic neuralgia, analgesia, opioid, nerve block, tricyclic antidepressant

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Impact of herpes zoster and postherpetic neuralgia on the quality of life of Germans aged 50 or above

Cited by 46 publications

References 44 publications

Depression as a mediator of quality of life in patients with neuropathic pain: A cross‐sectional study

Depression as a mediator of quality of life in patients with neuropathic pain: A cross‐sectional study

Economic Burden and Impact on Quality of Life of Herpes Zoster in Spanish Adults Aged 50 Years or Older: A Prospective Cohort Study

Delayed Initiation of Supplemental Pain Management is Associated with Postherpetic Neuralgia: A Retrospective Study

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