Economic Burden and Impact on Quality of Life of Herpes Zoster in Spanish Adults Aged 50 Years or Older: A Prospective Cohort Study

Díez‐Domingo, Javier; Curran, Desmond; Cambronero, Maria Del Rosario; García-Martínez, Juan-Antonio; Matthews, Sean

doi:10.1007/s12325-021-01717-7

Cited by 23 publications

(17 citation statements)

References 35 publications

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“…A recent study estimated the economic burden of herpes zoster in Spanish adults aged 50 years or older from an NHS and societal perspective. The results of this analysis were aligned with the present study: costs were higher in older age groups and, in the distribution of direct costs, the burden was derived mainly from PC visits (44.9%; compared with 49.6% in the present study) [ 27 ].…”

Section: Discussionsupporting

confidence: 85%

Direct Medical Costs of Four Vaccine-Preventable Infectious Diseases in Older Adults in Spain

Miguel

Bouza

Alcorta

et al. 2022

PharmacoEconomics Open

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Section: Discussionsupporting

confidence: 85%

Direct Medical Costs of Four Vaccine-Preventable Infectious Diseases in Older Adults in Spain

Miguel

Bouza

Alcorta

et al. 2022

PharmacoEconomics Open

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“…ZAP can adversely affect patients' abilities to perform daily self-care tasks, reduce their QoL, and significantly increase family and socioeconomic burdens [15]. Most cohort or case-control studies have focused on the risk factors and related predictive models of PHN [16,17], but no study has evaluated factors related to the efficacy of hospitalization in patients with ZAP.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Poor Pain Control in Zoster-Associated Pain: A Retrospective Study

et al. 2022

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Introduction:The objective was to investigate the risk factors for poor pain control in patients with herpes zoster (HZ)-associated neuropathic pain treated with drugs combined with nerve block therapy. Neuropathic pain commonly follows HZ. Nerve block therapy is the most commonly used clinical treatment for such pain, combining anti-inflammation and analgesia to prevent peripheral sensitization of nerve. Methods: Using clinical practice data from a cohort study at our research center, we established a multivariate logistic regression model to investigate potential risk factors for poor control of zoster-associated pain (ZAP) treated with drugs plus nerve block therapy, including demographic characteristics, complications, laboratory tests, and characteristics of HZ attacks. Results: Of the 429 patients with ZAP who received drugs plus nerve block therapy, 95 (22.14%) had poor pain control after treatment. The risk of poor pain control was closely related to presence of cancer (odds ratio (OR) 4.173, 95% confidence interval (CI) 1.342-12.970), numerical rating scale score on admission (OR 1.929, 95% CI 1.528-2.434), and red blood cell count (OR 0.560, 95% CI 0.328-0.954). Area under the receiver operator characteristic curve was 0.730. Goodness of fit (Hosmer-Lemeshow) was 0.874. Conclusions: The risk of poor pain control in patients with ZAP increased as a result of certain patient characteristics and complications, especially severe pain before treatment and cancer.

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“…In addition to the formal search, we explored reference lists of included articles for possible additional studies, and one study was added. 16…”

Section: Methodsmentioning

confidence: 99%

Patient-reported quality of life in patients suffering from acute herpes zoster—a systematic review with meta-analysis

Sollie¹,

Jepsen²,

Sørensen³

2022

British Journal of Pain

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Objectives Herpes Zoster (HZ) is a common painful, debilitating condition caused by reactivation of the varicella-zoster virus. It is characterized by a painful skin eruption which is very complex to treat. Studies have reported that HZ negatively affects Quality of Life (QoL), but no large systematic review on this topic has been published to date. This systematic review aims to summarize the current data on patient-reported QoL amongst patients diagnosed with HZ. Methods We searched MEDLINE, EMBASE, Cochrane Library, CINAHL, and PsycINFO. The primary outcome was the change in percent impairment of QoL compared to normative data. Secondary outcomes were meta-analyses comparing reported QoL to a control group or normative data. Results We assessed a total of 536 studies for inclusion. Thirteen studies were included in the systematic review and five studies in the meta-analyses. The total number of patients was 5472. Conclusions This systematic review and meta-analysis found lower reported Quality of Life amongst patients diagnosed with acute herpes zoster compared to normative values. Our data show that acute herpes zoster significantly reduces the quality of life of the patients affected.

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Economic Burden and Impact on Quality of Life of Herpes Zoster in Spanish Adults Aged 50 Years or Older: A Prospective Cohort Study

Cited by 23 publications

References 35 publications

Direct Medical Costs of Four Vaccine-Preventable Infectious Diseases in Older Adults in Spain

Direct Medical Costs of Four Vaccine-Preventable Infectious Diseases in Older Adults in Spain

Risk Factors for Poor Pain Control in Zoster-Associated Pain: A Retrospective Study

Patient-reported quality of life in patients suffering from acute herpes zoster—a systematic review with meta-analysis

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