Impact of Gestational Diabetes Mellitus and Maternal Obesity on Cord Blood Dynamic Thiol/Disulfide Homeostasis

Özler, Sibel; Öztaş, Efser; Erel, Özcan; Guler, Basak Gumus; Ergin, Merve; Uygur, Dilek; Danışman, Nuri

doi:10.1080/15513815.2016.1223237

Cited by 10 publications

(9 citation statements)

References 18 publications

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“…Ozler et al (23) reported increased disulphide/native thiol and disulphide/total thiol ratios, while native thiol/total thiol decreased in the cord blood of babies born to a mother with obesity or diabetes mellitus, and associated these rates with adverse outcomes in gestational diabetes mellitus. In another study, while disulphide/native thiol and disulphide/total thiol ratios were elevated, the native thiol/total thiol ratio decreased in a group with chronic central serous chorioretinopathy group compared to healthy individuals (13).…”

Section: Discussionmentioning

confidence: 99%

Thiol/Disulphide homeostasis, ischemia modified albumin, and ferroxidase as oxidative stress markers in women with obesity with insulin resistance

Ateş¹,

Set²,

Karahan³

et al. 2019

Journal of Medical Biochemistry

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Summary Background The purpose of the study was to determine oxidative stress-related plasma thiol/disulphide, ischemia-modified albumin (IMA) levels and ferroxidase activity among women with obesity in insulin-resistant and non-insulin-resistant groups in comparison with an overweight group. Methods We compared plasma thiol/disulphide, IMA levels, and ferroxidase activity between the study groups. We analyzed plasma thiol/disulphide homeostasis with a newly developed automated measurement method; IMA with Albumin Cobalt Binding Test and ferroxidase (ceruloplasmin) levels with an automated, colourimetric method. Results There were no significant differences between insulin-resistant and non-insulin-resistant women with obesity in terms of plasma native thiol, total thiol, disulphide, disulphide/native thiol ratio, disulphide/total thiol or native thiol/total thiol values. Ferroxidase activity was higher in insulin-resistant than in non-insulin-resistant women with obesity and higher in the total women with obesity group than in the overweight subjects (p<0.001, and p=0.014, respectively). IMA was lower in the insulin-resistant group than in the non-insulin-resistant group and overweight groups (p=0.011, and p=0.042, respectively). Conclusions The significantly greater increase in ferroxidase activity in insulin-resistant subjects with obesity may reflect its role as a positive acute phase protein. These findings may be related to the pathogenesis of the disease. Changes in oxidative status occur in women with obesity, and partially in overweight subjects. The ferroxidase activity of ceruloplasmin plays a crucial role in iron homeostasis and lowers oxidative stress by reducing the detrimental effects of iron.

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Section: Discussionmentioning

confidence: 99%

Thiol/Disulphide homeostasis, ischemia modified albumin, and ferroxidase as oxidative stress markers in women with obesity with insulin resistance

Ateş¹,

Set²,

Karahan³

et al. 2019

Journal of Medical Biochemistry

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“…There are several studies investigating association between TDH and gestational diabetes mellitus [94][95][96][97]. It has been demonstrated that NT and TT levels were found to be lower than control subjects and decreased NT levels have an increased risk of possible adverse perinatal outcomes [95].…”

Section: Obstetric and Gynecologic Disordersmentioning

confidence: 99%

“…Disulfide levels were found to be higher in patients with gestational diabetes mellitus compared to healthy pregnant women and in obese pregnant compared to healthy pregnant women. Authors have suggested that infants of obese or diabetic mothers are exposed to increased oxidative stress [94]. In another study, authors have demonstrated that 50 grams glucose challenge test-positive pregnant women have increased disulfide levels after glucose loading compared to baseline [97].…”

Section: Obstetric and Gynecologic Disordersmentioning

confidence: 99%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition to thiol-termed as native thiol-levels, disulfide levels were also measured and sum of native thiol and disulfide levels were termed as total thiol. Therefore, TDH was begun to be understood in organism. In healthy humans, TDH is maintained within a certain range. Dysregulated dynamic TDH has been implicated several disorders with unknown etiology. A growing body of evidence has demonstrated that the thiol-disulfide homeostasis is involved in variety diseases, such as diabetes mellitus, hypertension, non-small cell lung cancer, Familial Mediterranean fever, inflammatory bowel diseases, occupational diseases, gestational diabetes mellitus and preeclampsia. These results may elucidate some pathogenic mechanism or may be a predictor indicating diagnostic clue, prognostic marker or therapeutic sign. In conclusion, protection of the thiol disulfide homeostasis is of great importance for the human being. Evidence achieved so far has proposed that thiol-disulfide homeostasis is an important issue needs to elucidate wholly.

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“…In addition, a greater number of patients are needed to enlighten the role of oxidant and antioxidant systems and other possible mechanisms in the pathogenesis of psoriasis. We believe that assessment of TDHS in patients with psoriasis in terms of BMI would provide valuable data as thiol levels were found to be higher in gestational diabetes mellitus and maternal obesity in a previous report 27 . Analysis of serum levels of certain molecules containing sulfur formed after the oxidation of thiol groups, such as cysteine, cysteinylglycine, GSH, homocysteine, and ɤ-glutamylcysteine could provide further scientific data about TDHS imbalance in the etiopathogenesis of psoriasis.…”

Section: Discussionmentioning

confidence: 72%

The role of thiol/disulfide homeostasis in psoriasis: Can it be a new marker for inflammation?

Üstüner¹,

Balevi²,

Özdemir³

et al. 2018

TURKDERM

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Psoriazis vulgaris oksidatif stres ve dokuda enflamasyon ile seyreden kronik, sistemik enflamatuvar bir hastalıktır. Tiyol ve disülfit seviyelerinin total oksidan durumun bir belirteci olarak enflamatuvar hastalıklarda arttığı gösterilmiştir. Bugüne kadar, seboreik dermatit, atopik dermatit, alopesi areata, akut ürtiker ve melasma gibi birçok dermatolojik hastalıkta tiyol/disülfit homeostazındaki dengesizlik ya da anormalliklerin etiyopatogenetik rolü olduğu gösterilmiştir. Psoriazis vulgariste tiyol ve disülfit kan seviyelerinin ya da tiyol/disülfit oranlarının artışını araştırmak ve yeni prognostik enflamatuvar belirteç olarak kullanılabilirliğini belirlemeyi amaçladık. Gereç ve Yöntem: Biyopsi ile tanı almış 29 psoriazis hastasındaki ve 30 sağlıklı kontrol grubunda natif tiyol, total tiyol ve disülfit kan seviyeleri araştırıldı. Natif-total tiyol, disülfit-natif tiyol ve disülfit-total tiyol oranları iki grup arasında karşılaştırıldı. Psoriazisli hastalarda bu ölçümler ve Psoriazis Alan ve Şiddet İndeks (PAŞİ) değerleri arasındaki korelasyonda incelendi.

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Impact of Gestational Diabetes Mellitus and Maternal Obesity on Cord Blood Dynamic Thiol/Disulfide Homeostasis

Abstract: The current study suggests that the offsprings born to obese or diabetic mothers are exposed to increased oxidative stress.

Cited by 10 publications

References 18 publications

Thiol/Disulphide homeostasis, ischemia modified albumin, and ferroxidase as oxidative stress markers in women with obesity with insulin resistance

Thiol/Disulphide homeostasis, ischemia modified albumin, and ferroxidase as oxidative stress markers in women with obesity with insulin resistance

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

The role of thiol/disulfide homeostasis in psoriasis: Can it be a new marker for inflammation?

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