Impact of dual-time-point 18F-FDG PET imaging and partial volume correction in the assessment of solitary pulmonary nodules

Alkhawaldeh, Khaled; Bural, Gonca; Kumar, Rakesh; Alavi, Abass

doi:10.1007/s00259-007-0584-1

Cited by 112 publications

(75 citation statements)

References 26 publications

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“…In pulmonary lesions, most benign pulmonary nodules do not accumulate FDG. However, active granulomatous infections like tuberculosis and sarcoidosis can demonstrate increased FDG uptake [21,22]. In our study, one FDG positive pulmonary nodule was thought to be an inflammatory nodule on the serial follow-up that showed no change in shape and size on the chest CT and decreased FDG uptake in the serial 18 …”

Section: Discussionmentioning

confidence: 79%

0029 The effects of preoperative 18F-FDG-PET/CT in breast cancer patients in comparison with conventional imaging study

Choi¹,

Kang²,

Nam³

et al. 2009

The Breast

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Section: Discussionmentioning

confidence: 79%

0029 The effects of preoperative 18F-FDG-PET/CT in breast cancer patients in comparison with conventional imaging study

Choi¹,

Kang²,

Nam³

et al. 2009

The Breast

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“…Delayed PET images are usually analyzed with VOIs, and any increase in SUVmax (10,11) or an increase in SUVmax greater than 10% are considered as criteria for malignancy (12,13). However, diagnostic criteria for dual-time-point 18 F-FDG PET images for the evaluation of brain tumors are not standardized.…”

Section: Discussionmentioning

confidence: 99%

Voxel-Based Analysis of Dual-Time-Point ¹⁸F-FDG PET Images for Brain Tumor Identification and Delineation

Prieto¹,

Martí-Climent²,

Domínguez-Prado³

et al. 2011

J Nucl Med

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We have investigated dual-time-point 18 F-FDG PET for the detection and delineation of high-grade brain tumors using quantitative criteria applied on a voxel basis. Methods: Twenty-five patients with suspected high-grade brain tumors and inconclusive MRI findings underwent 11 C-methionine PET and dual-time-point 18 F-FDG PET. Images from each subject were registered and spatially normalized. Parametric maps of standardized uptake value (SUV) and tumor-to-normal gray matter (TN) ratio for each PET image were obtained. Tumor diagnosis was evaluated according to 4 criteria comparing standard and delayed 18 F-FDG PET images: any SUV increase, SUV increase greater than 10%, any TN increase, and TN increase greater than 10%. Voxel-based analysis sensitivity was assessed using 11 C-methionine as a reference and compared with visual and volume-of-interest analysis for dual-timepoint PET images. Additionally, volumetric assessment of the tumor extent that fulfills each criterion was compared with the volume defined for 11 C-methionine PET. Results: The greatest sensitivity for tumor identification was obtained with any increase of TN ratio (100%), followed by a TN increase greater than 10% (96%), any SUV increase (80%), and an SUV increase greater than 10% (60%). These values were superior to visual analysis of standard 18 F-FDG (sensitivity, 40%) and delayed 18 F-FDG PET (sensitivity, 52%). Volume-of-interest analysis of dual-time-point PET reached a sensitivity of only 64% using the TN increase criterion. Regarding volumetry, voxel-based analysis with the TN ratio increase as a criterion, compared with 11 C-methionine PET, detected 55.4% of the tumor volume, with the other criteria detecting volumes lower than 20%. Nevertheless, volume detection presented great variability, being better for metastasis (78%) and glioblastomas (56%) than for anaplastic tumors (12%). A positive correlation was observed between the volume detected and the time of acquisition of the delayed PET image (r 5 0.66, P , 0.001), showing volumes greater than 75% when the delayed image was obtained at least 6 h after 18 F-FDG injection. Conclusion: Compared with standard 18 F-FDG PET studies, quantitative dual-time-point 18 F-FDG PET can improve sensitivity for the identification and volume delineation of high-grade brain tumors.

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“…35 Ten publications 28,29,31,33,34,[36][37][38][39][40] fulfilled all of the inclusion criteria, with a total of 816 patients and 890 pulmonary nodules. Multiple different thresholds were used to define a pulmonary nodule as malignant between the initial and later images.…”

Section: Lung Cancermentioning

confidence: 99%

“…29 All underwent total-body FDG-PET 60 minutes after tracer injection, and 255 patients underwent a second FDG-PET for chest 100 minutes after injection. Partial volume correction for first time SUV (corrSUV1) was applied using recovery coefficient method adopted and modified from the literature.…”

Section: Lung Cancermentioning

confidence: 99%

Use of Dual-Point Fluorodeoxyglucose Imaging to Enhance Sensitivity and Specificity

Schillaci

2012

Seminars in Nuclear Medicine

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Positron emission tomography (PET) and positron emission tomography/computed tomography imaging with fluorodeoxyglucose (FDG) are widely used as a powerful evaluation modality in oncological nuclear medicine not only for detecting tumors but also for staging and for therapy monitoring. Nevertheless, there are numerous causes of FDG uptake in benign processes seen on PET images. In fact, the degree of FDG uptake is related to the cellular metabolic rate and the number of glucose transporters. FDG accumulation in tumors is due, in part, to an increased number of glucose transporters in malignant cells. However, FDG is not specific for neoplasms: a similar situation exists in inflammation; activated inflammatory cells demonstrate increased expression of glucose transporters. Therefore, there is growing interest in improving the specificity of FDG-PET in patients with cancer. Preliminary studies showed that in several neoplasms, the uptake of FDG continues to increase for hours after radiopharmaceutical injection, and this difference in the time course of FDG uptake could be useful to improve the accuracy of PET to distinguish benign lesions from malignant ones. Also in experimental cultures, dual-point acquisition (early at 40-60 minutes postinjection and delayed at 90-270 minutes) demonstrated that it is able to differentiate inflammatory from neoplastic tissue. In general, inflammatory tissue is expected to reduce FDG uptake as the time goes by, whereas the uptake in the neoplastic lesions is supposed to be increasing. There is evidence in the recent literature of the clinical usefulness of dual-time-point FDG-PET imaging in a wide variety of malignancies, including those of head and neck, lung, breast, gallbladder, cervix, liver, and in brain tumors. A lesion is likely to be malignant if the standard uptake value increases over time, whereas it is likely to be benign if the standard uptake value is stable or decreases. It is worth noting that in many of these studies, dual-time-point PET improved not only the specificity but also the sensitivity in assessing breast, pulmonary, liver, and other tumors because of increased lesion-to-background ratio, as a consequence of FDG washout from the surrounding normal tissues and increasing neoplastic uptake. Semin Nucl Med 42:267-280

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Impact of dual-time-point 18F-FDG PET imaging and partial volume correction in the assessment of solitary pulmonary nodules

Abstract: Dual-time-point (18)F-FDG PET has potential impact on improving the diagnostic accuracy for malignant lung nodules. Dual-time-point (18)F-FDG PET imaging should be included in the clinical work-up of patients with pulmonary nodule.

Cited by 112 publications

References 26 publications

0029 The effects of preoperative 18F-FDG-PET/CT in breast cancer patients in comparison with conventional imaging study

0029 The effects of preoperative 18F-FDG-PET/CT in breast cancer patients in comparison with conventional imaging study

Voxel-Based Analysis of Dual-Time-Point ¹⁸F-FDG PET Images for Brain Tumor Identification and Delineation

Use of Dual-Point Fluorodeoxyglucose Imaging to Enhance Sensitivity and Specificity

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Impact of dual-time-point 18F-FDG PET imaging and partial volume correction in the assessment of solitary pulmonary nodules

Abstract: Dual-time-point (18)F-FDG PET has potential impact on improving the diagnostic accuracy for malignant lung nodules. Dual-time-point (18)F-FDG PET imaging should be included in the clinical work-up of patients with pulmonary nodule.

Cited by 112 publications

References 26 publications

0029 The effects of preoperative 18F-FDG-PET/CT in breast cancer patients in comparison with conventional imaging study

0029 The effects of preoperative 18F-FDG-PET/CT in breast cancer patients in comparison with conventional imaging study

Voxel-Based Analysis of Dual-Time-Point 18F-FDG PET Images for Brain Tumor Identification and Delineation

Use of Dual-Point Fluorodeoxyglucose Imaging to Enhance Sensitivity and Specificity

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Voxel-Based Analysis of Dual-Time-Point ¹⁸F-FDG PET Images for Brain Tumor Identification and Delineation