Use of Dual-Point Fluorodeoxyglucose Imaging to Enhance Sensitivity and Specificity

Abstract

Positron emission tomography (PET) and positron emission tomography/computed tomography imaging with fluorodeoxyglucose (FDG) are widely used as a powerful evaluation modality in oncological nuclear medicine not only for detecting tumors but also for staging and for therapy monitoring. Nevertheless, there are numerous causes of FDG uptake in benign processes seen on PET images. In fact, the degree of FDG uptake is related to the cellular metabolic rate and the number of glucose transporters. FDG accumulation in tumors is due, in part, to an increased number of glucose transporters in malignant cells. However, FDG is not specific for neoplasms: a similar situation exists in inflammation; activated inflammatory cells demonstrate increased expression of glucose transporters. Therefore, there is growing interest in improving the specificity of FDG-PET in patients with cancer. Preliminary studies showed that in several neoplasms, the uptake of FDG continues to increase for hours after radiopharmaceutical injection, and this difference in the time course of FDG uptake could be useful to improve the accuracy of PET to distinguish benign lesions from malignant ones. Also in experimental cultures, dual-point acquisition (early at 40-60 minutes postinjection and delayed at 90-270 minutes) demonstrated that it is able to differentiate inflammatory from neoplastic tissue. In general, inflammatory tissue is expected to reduce FDG uptake as the time goes by, whereas the uptake in the neoplastic lesions is supposed to be increasing. There is evidence in the recent literature of the clinical usefulness of dual-time-point FDG-PET imaging in a wide variety of malignancies, including those of head and neck, lung, breast, gallbladder, cervix, liver, and in brain tumors. A lesion is likely to be malignant if the standard uptake value increases over time, whereas it is likely to be benign if the standard uptake value is stable or decreases. It is worth noting that in many of these studies, dual-time-point PET improved not only the specificity but also the sensitivity in assessing breast, pulmonary, liver, and other tumors because of increased lesion-to-background ratio, as a consequence of FDG washout from the surrounding normal tissues and increasing neoplastic uptake. Semin Nucl Med 42:267-280

Standardization of dual time point [18F] 2-Deoxy-2-fluoro-D-glucose-positron emission tomography performed with different positron emission tomography scanners using partial volume correction

“…[2][3][4][5] In addition, the same trend has also been reported in malignant breast lesions. The increasing uptake of FDG over time in breast malignancies has been suggested to be helpful in enhancing the diagnostic accuracy of FDG-PET studies.…”

“…6 Several studies have reported that dual time point FDG-PET examinations with relative changes in uptake improve the sensitivity and accuracy of diagnosing breast cancer. 2,3,[6][7][8][9][10][11] The standardized uptake value (SUV) is widely used for quantitative evaluation in FDG-PET studies. However, the SUV varies depending on the PET image quality, submit your manuscript | www.dovepress.com…”

The Role of Delayed 18F-FDG PET Imaging in the Follow-up of Patients with Alveolar Echinococcosis

“…The perilesional location of 18 F-FDG uptake, as well as negative findings at the early acquisition time despite the presence of viable parasite, suggests that the periparasitic immune infiltrate is responsible for the increased uptake of 18 F-FDG in AE. Unlike most of the usual inflammatory or infectious diseases that have been studied using 18 F-FDG PET (30,31), AE lesions do not include any polymorphonuclear neutrophils, thus perhaps explaining why delayed acquisition reinforced the PET images rather than decreasing the signal on dual-time-point imaging. A rather unusual metabolism of the periparasitic immune cells that are maintained in a chronic status of tolerance might also explain an increase in 18 F-FDG uptake with time (32).…”

Early PET-CT After Stereotactic Radiotherapy for Stage 1 Non-small Cell Lung Carcinoma Is Predictive of Local Control

“…Interpretation and comparison of SUV values is difficult, depending on technical, biological and physical parameters (20). Although an SUV max of 5 is frequently proposed as a threshold (14,21) can be made from data of other centers because of different technical parameters (22,23). The four patients with uninterpretable results in our patient set had a low initial SUV max (<5).…”