Standardization of dual time point [18F] 2-Deoxy-2-fluoro-D-glucose-positron emission tomography performed with different positron emission tomography scanners using partial volume correction

Abstract

Introduction:The aim of this study was to examine the possibility of using the partial volume correction (PVC) to standardize dual time point [18F] 2-Deoxy-2-fluoro-D-glucose (FDG)-positron emission tomography (PET) studies with two PET scanners. Materials and methods: One hundred and thirteen lesions from 96 breast cancer patients were examined. FDG-PET scans were performed at both 60 and 120 minutes after FDG injection using different PET scanners. The maximum standardized uptake values (SUV max s) were measured at both time points (SUV max 1 and SUV max 2) and the percent change in the SUV max (∆%SUV max ) between the two time points was calculated. PVC was performed using a look-up table generated based on the recovery coefficient curves and point spread function of each scanner. Results: The SUV max 1, the SUV max 2, and the ∆%SUV max were 5.67±4.45, 5.15±4.29, and -9.30%±20.54%, respectively. After PVC, all parameters significantly increased to 10.44±5.55, 10.23±5.77, and -1.15%±21.66%, respectively. In addition, the number of lesions with a positive ∆%SUV max increased after PVC, from 26.5% to 40.7%. Conclusion: PVC of the SUV max is considered to be useful for standardizing dual time point FDG-PET studies in patients with breast cancer performed using different PET scanners. This method is also expected to be useful for standardizing multicenter PET studies.