Impact of dietary intervention devoid of probable endocrine disruptors among hypothyroid obese women consuming Levothyroxine -A Case study

Abstract

Background: Hypothyroidism among obese women is one of the concerned endocrine disorders nowadays. Data shows that at least one female member suffers in almost every family in some metro cities. Iodine deficiency was one of the main factors, but it is no longer a significant cause for two decades due to its sufficient availability. So the expected risk factors are obesity and endocrine disruptors available in foods and the environment. Objective: The study aims to determine the association between obesity and hypothyroidism among housewives living in Kolkata. Further, to evaluate hypothyroid to the euthyroid state through endocrine disruptors free dietary intervention. Methods: This qualitative study was based on purposive sampling, including BMI, thyroid profile tests, and relevant blood reports. The dietary intervention was considered for 120 obese hypothyroid housewives within 35-45 years in Kolkata city and peripherals. The study was conducted for March-August in 2019 with Levothyroxine treatment for the 1st three months, followed by the next three months without this medicine but only dietary interventions. SPSS version 16 has been applied for the data analysis. Results: The study revealed no such insufficiency of supplements that raised TSH and changed normal or subnormal T4 among the participants. The correlation coefficient for BMI and hypothyroid type was r = 0.524 and r = 0.425, p=.000 (p< 0.001 or p=0.000 or p<0.0005); BMI with TSH r = 0.554 and 0.437. So there was a significant relationship between obesity and hypothyroidism in association with comorbidities. Further, nine participants became normal weight, and fourteen progressed into mild status due to dietary interventions. Conclusions: The study showed a positive association between hypothyroidism and obesity and their comorbidities. Further, the hypothyroid diet plan devoid of endocrine disruptors worked remarkably without Levothyroxine.