Biochemical study on Anti Thyroid Peroxidase Antibody Enzyme in Serum Blood of women with Thyroid Disease

Abstract

The research involved study the relation between thyroid peroixdase (TPO) and some of the measured biochemical parameters related to the disease (Triiodothyhyronin T3, Thyroxine T4, Thyroid stimulating hormone TSH, glucosee, vitamin D, calcium, uric acid, albumin, alkaline phosphatase enzyme (ALP), transamination enzymes GOT and GPT)in serum blood patients compared with control group, the reasult demonstration is a significant increase in the mean of TPO enzyme (112.63±69.5 Iu/ml), (273.9±235.1 Iu/ml)in hyperthyroidism and hypothyroidism patient respectively compared with mean in control group was ( 33.9 ±18.99 Iu/ml), also the results showed the significant increase in the concentration of T3, glucose, ALP, GOT, GPT enzymes and non significant increase inT4, uric acid, while a significant decrease in TSH, vitamin D, calcium, and non significant decrease with albumin in hyperthyroidism while the results had been shown a significant increase in TSH, glucose, ALP and non-significant increase in uric acid, GOT, GPT enzymes and a significant decrease in T4, vitamin D, calcium, non- significant decrease in T3, albumin in hypothyroidism . Correlation coefficient of TPO enzyme with these clinical parameters showed a negative significant correlation with GPTenzyme in hyperthyroidism and vitamin D, calcium in hypothyroidism while the results showed that there is no significant relationship of TPO enzyme with the rest of boichemical parameters conclusion of this study was that anti-TPO enzyme is diagnosis of autoimmune thyroid disorders and TPO enzyme is plays an important role in making thyroid hormones