The research involved study the relation between thyroid peroixdase (TPO) and some of the measured biochemical parameters related to the disease (Triiodothyhyronin T3, Thyroxine T4, Thyroid stimulating hormone TSH, glucosee, vitamin D, calcium, uric acid, albumin, alkaline phosphatase enzyme (ALP), transamination enzymes GOT and GPT)in serum blood patients compared with control group, the reasult demonstration is a significant increase in the mean of TPO enzyme (112.63±69.5 Iu/ml), (273.9±235.1 Iu/ml)in hyperthyroidism and hypothyroidism patient respectively compared with mean in control group was ( 33.9 ±18.99 Iu/ml), also the results showed the significant increase in the concentration of T3, glucose, ALP, GOT, GPT enzymes and non significant increase inT4, uric acid, while a significant decrease in TSH, vitamin D, calcium, and non significant decrease with albumin in hyperthyroidism while the results had been shown a significant increase in TSH, glucose, ALP and non-significant increase in uric acid, GOT, GPT enzymes and a significant decrease in T4, vitamin D, calcium, non- significant decrease in T3, albumin in hypothyroidism . Correlation coefficient of TPO enzyme with these clinical parameters showed a negative significant correlation with GPTenzyme in hyperthyroidism and vitamin D, calcium in hypothyroidism while the results showed that there is no significant relationship of TPO enzyme with the rest of boichemical parameters conclusion of this study was that anti-TPO enzyme is diagnosis of autoimmune thyroid disorders and TPO enzyme is plays an important role in making thyroid hormones
The research involved study the relation between thyroid peroixdase (TPO) and some of the measured biochemical parameters reduced glutathione (GSH), arylesterase (ARE), ceruloplasmin, malondialdehyde, cholesterol, triglyceride, LDL, VLDL, HDL, atherogenic index)in serum blood patients compared with control group, the result demonstration is a significant increase in the activity of TPO enzyme(112.63± 69.5 Iu/ml), (273.9±235.1 Iu/ml) in hyperthyroidisum and hypothyroidisum patient respectively compared with activity in control group was( 33.9 ±18.99 Iu/ml), also the results showed the significant increase in the concentration of (HDL), significant decrease in (GSH, ARE enzymes, cholestero, LDL, atherogenic index) and while a non significant increase in (ceruloplasmin,malondialdehyde), non significant decrease in(triglyceride, VLDL) in hyperthyroidism, also the results had been shown a significant increase in (malondialdehyde, triglyceride, VLDL), and a significant decrease in (GSH, ARE enzymes) while a non significant increase in (ceruloplasmin, cholesterol, LDL, atherogenic index) and a non significant decrease in (HDL) in hypothyroidism, Correlation coefficient of TPO enzyme with these clinical parameters showed a positive significant correlation with (GSH enzyme)in control group and with (HDL) in hyperthyroidism while the results showed that there is no significant correlation between TPO enzyme with the rest of boichemical parameters (GSH enzyme).
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