Impact of COVID-19 pandemic on vaccination against meningococcal C infection in Brazil

Silva, Thales Philipe Rodrigues da; Brandão, Leyla Gabriela Verner Amaral; Vieira, Ed Wilson Rodrigues; Maciel, Thalita Beatriz Santos; Silva, Tércia Moreira Ribeiro da; Luvisaro, Bianca Maria Oliveira; Menezes, Fabiana Ramos de; Matozinhos, Fernanda Penido

doi:10.1016/j.jvacx.2022.100156

Cited by 6 publications

(4 citation statements)

References 37 publications

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“…The number of cases among children younger than 2 years has diminished posterior the introduction of Meningococcal C vaccine in the National Immunization Program in Brazil (Cardoso et al, 2015). However, the vaccination rates for this disease were considerably reduced in all states and in the Federal District of Brazil, during the COVID-19 pandemic (da Silva et al, 2022). Children who were not vaccinated can be infected by Meningococcal disease, suffering harmful consequences, including hearing loss like the patient reported in this study.…”

Section: Discussionmentioning

confidence: 58%

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Childhood meningitis and delay of four years in diagnosing bilateral profound sensorineural hearing loss: a case report

Nunes

Campello

Lima

et al. 2022

RSD

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Globally around 34 million children present disabling hearing loss. If unaddressed, hearing loss can negatively impact several aspects such as communication, cognition, language, and speech. Most needy people with hearing impairment do not have access to treatments and it’s a national and international public health problem. Meningococcal disease is caused by the bacterium Neisseria meningitides, affects mainly children, can cause hearing loss, and is a global public health challenge. This study aimed to present the case report of a child who acquired meningococcal disease and bilateral profound sensorineural hearing loss in primary infancy. At the age of six months, the child acquired meningococcal meningitis and performed antibiotic therapeutics. Four years later, the audiometric evaluation detected hearing loss. At the age of seven years, the patient started speech language therapy sessions. At the age of nine years, hearing prostheses were provided by a hospital. At the age of ten, the child began to deny the use of hearing aids at home and school. Two years later, she started her studies at a special school where the deaf community is clearly present. At the age of fourteen, the patient became completely fluent in Sign language, stopping speech therapy sessions. The analyzed case demonstrated a lack of children’s surveillance by a multidisciplinary team and the relevance of following children’s guidance vaccination. It is required to provide adequate interventions for children with hearing loss, which can potentially aid them to develop their skills and to achieve a better quality of life.

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Section: Discussionmentioning

confidence: 58%

“…In 2010, the Meningococcal C conjugate vaccine was implemented in Brazil (da Silva et al, 2022). In 2000, when the patient acquired meningitis this vaccine was not implemented yet.…”

Section: Discussionmentioning

confidence: 99%

Childhood meningitis and delay of four years in diagnosing bilateral profound sensorineural hearing loss: a case report

Nunes

Campello

Lima

et al. 2022

RSD

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“…Para além da meta de cobertura estipulada, a OMS evidencia também outros indicadores relevantes nesse contexto, como a homogeneização das coberturas vacinas dentro do território 9 . Nos últimos anos, o Brasil 3,10-13 e todo o mundo experenciaram a queda da cobertura vacinal de vários imunobiológicos, queda potencializada pela pandemia causada pelo coronavírus (COVID-19) [14][15][16] .…”

Section: Introductionunclassified

Classificação de risco para transmissão de doenças imunopreveníveis em Minas Gerais, Brasil: dois anos desde o início da pandemia de COVID-19

Silva

Vimieiro

Gusmão

et al. 2023

Ciênc. saúde coletiva

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Resumo O objetivo é analisar a classificação de risco de transmissão de doenças imunopreveníveis nos 853 municípios de Minas Gerais (MG) após dois anos de início da pandemia de COVID-19. Estudo epidemiológico com dados secundários da cobertura vacinal e taxa de abandono de dez imunobiológicos recomendados para crianças menores de 2 anos, no ano de 2021, em MG. Em relação à taxa de abandono, este indicador foi avaliado somente para as vacinas multidoses. Após o cálculo de todos os indicadores, os municípios do estado foram classificados de acordo com o risco de transmissão de doenças imunopreveníveis em cinco estratos. Minas Gerais apresentou 80,9% dos municípios classificados como alto risco para transmissão de doenças imunopreveníveis. Em relação à homogeneidade das coberturas vacinais (HCV), os municípios de grande porte apresentaram a maior porcentagem de HCV classificada como muito baixa e 100% desses municípios foram classificados como de alto ou muito alto risco para transmissão de doenças imunopreveníveis, com significância estatística. A utilização de indicadores de imunização por município é efetiva para o delineamento do cenário de cada território e a proposição de políticas públicas em saúde visando o aumento das coberturas vacinais.

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“…The Brazilian National Immunization Program (PNI) was launched in 1973; it is globally acknowledged for its comprehensive vaccination schedule, which covers different life cycles and speci c populations [1;3]. However, reduced vaccination coverage has been observed in the recent global scenario, due to the in uence from factors such as the COVID-19 pandemic, vaccine hesitancy, spread of misinformation about vaccines (Fake news) in social networks, as well as decreased perception about disease-related risks [4][5][6][7][8][9][10][11][12][13]. The World Health Organization (WHO) recommends 95% vaccination coverage for most vaccines to help eradicating, eliminating or controlling immunopreventable diseases [14].…”

Section: Introductionmentioning

confidence: 99%

Spatial and Trend Analysis of Meningococcal C Vaccination Coverage in Children Living in Brazil Between 2011 and 2021: an Ecological Study

Pereira

Silva

Rodrigues

et al. 2022

Preprint

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Background Immunization is an important public health intervention worldwide, since it helps preventing, controlling, eradicating and reducing the number of death cases resulting from immunopreventable diseases. Meningococcal C conjugate vaccine (MenC) was made available for children under 2 years old due to significant increase in the number and rate of meningococcal disease (MD) serogroup C cases in Brazil, which recorded outbreaks in different regions. Identifying regions with low MenC vaccine application coverage is a priority strategy to target immunization actions, as well as to reduce the risk of DM circulation in different countries. Spatial analysis can help identifying areas with large numbers of children susceptible to MD, as well as directing priority health policies and strategies to these regions. The aim of the current study is to analyze meningococcal C vaccination coverage based on temporal trends in MenC vaccine coverage over 11 years, as well as the spatial distribution of MenC vaccine coverage, based on identifying spatial clusters with large numbers of children susceptible to MD. Methods This ecological, mixed study was conducted with secondary data about MenC vaccine coverage from 2011 to 2021, in Brazil, and made available by the National Immunization Program Information System (SI-PNI). This ecological, mixed study was conducted with secondary data about MenC vaccine coverage from 2011 to 2021, in Brazil, and made available by the National Immunization Program Information System (SI-PNI). Descriptive analysis was used to assess the annual coverage of MenC vaccine, based on geographic region, by taking into consideration all 26 Brazilian Federative Units (UF), the Federal District and the analyzed years. Prais-Winsten linear regression model was used for trend analysis purposes: MenC vaccination coverage per state, per Brazilian region (all five regions), and MenC vaccination coverage countrywide were used as dependent variables. Analyzed years were used as independent variable. Spatial dependence and incidence of spatial clusters formed by municipalities with high and low MenC vaccination coverage were assessed through spatial statistical analysis. Results In the current study have evidenced downward trend in MenC vaccination coverage in Brazil, in all five Brazilian regions and in 20 of the 27 Brazilian states, as well as progressive increase in the number of spatial clusters with low vaccination coverage, mainly in Northern and Northeastern Brazil. Conclusion These findings are expected to influence the formulation of practices, policies, programs and actions based on robust scientific evidence about the development of MD prevention and health promotion strategies and interventions, both at national and global level.

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Impact of COVID-19 pandemic on vaccination against meningococcal C infection in Brazil

Cited by 6 publications

References 37 publications

Childhood meningitis and delay of four years in diagnosing bilateral profound sensorineural hearing loss: a case report

Childhood meningitis and delay of four years in diagnosing bilateral profound sensorineural hearing loss: a case report

Classificação de risco para transmissão de doenças imunopreveníveis em Minas Gerais, Brasil: dois anos desde o início da pandemia de COVID-19

Spatial and Trend Analysis of Meningococcal C Vaccination Coverage in Children Living in Brazil Between 2011 and 2021: an Ecological Study

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