Impact of COVID‐19 in Liver Disease Progression

Martı́nez, Miguel Ángel; Franco, Sandra

doi:10.1002/hep4.1745

Cited by 42 publications

(38 citation statements)

References 121 publications

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“…Using the MELD score, clinicians can determine the level of care for cirrhotic patients, especially those infected with COVID-19 [10,11]. While the existing literature is currently limited, studies have shown that those with chronic liver disease, such as our patient, will have elevated MELD scores and suffer increased hepatic and pulmonary complications when infected with COVID-19 [4,10,11]. Specifically, the mortality rate in patients infected with COVID-19 with preexisting alcoholic liver disease is upwards of 1.8 times higher than those without the preexisting condition.…”

Section: Discussionmentioning

confidence: 99%

Rapid Turn From Cirrhosis to Encephalopathy Following COVID-19 Infection: A Cautionary Tale

Chowdhury¹,

Sultana²,

Dutta³

et al. 2022

Cureus

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The coronavirus disease 2019 infection has most commonly led to patients presenting with pulmonary disease, including severe acute respiratory syndrome. However, in about 14-53% of patients with a newly diagnosed COVID-19 infection, the liver is the organ most drastically affected, as opposed to the lungs. In patients with preexisting liver damage, the first symptom of a COVID-19 infection may come from worsening liver failure such as hepatic encephalopathy or worsening ascites. This case report highlights this unusual presentation of a COVID-19 infection in a patient with preexisting alcoholic liver cirrhosis. We report this case to heed warning that acutely worsening liver failure may be the first presenting symptom of a superimposed COVID-19 infection on preexisting liver disease.

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Section: Discussionmentioning

confidence: 99%

Rapid Turn From Cirrhosis to Encephalopathy Following COVID-19 Infection: A Cautionary Tale

Chowdhury¹,

Sultana²,

Dutta³

et al. 2022

Cureus

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“…Also, membrane less SARS-CoV-2 vesicles have been recognized in the hepatocyte's cytoplasm of two COVID-19 patients along with high expression of liver damage markers [184]. The SARS-CoV-2 mediated hypoxia and cytokine storm could also potentiate liver injury [179]. Meanwhile some other studies reported that antiviral drugs used for the support of COVID-19 patients could also induce hepatotoxicity.…”

Section: Liver Diseasementioning

confidence: 95%

“…Generally the chronic liver disease (CLD) is correlated with immune dysregulation and inflammation, which may present a greater risk of COVID-19 mediated pathogenesis [179]. Recent shreds of evidence support the cross talk between SARS-CoV-2 infection and CLD.…”

Section: Liver Diseasementioning

confidence: 99%

“…Some clinical studies have divulged that patient with COVID-19 symptoms are having elevated level of aspartate transferase (AST), alanine transferase (ALT), alkaline phosphatase (ALP) and gamma-glutamyltransferase (GGT). High level of these markers is generally correlated with liver injury [179][180][181]. A recent clinical report revealed that 2-11% of overall COVID-19 patients have underlying CLD and 14-53% with COVID-19 associated hepatic dysfunction [182].…”

Section: Liver Diseasementioning

confidence: 99%

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Jeopardy of COVID-19: Rechecking the Perks of Phytotherapeutic Interventions

et al. 2021

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The novel coronavirus disease (COVID-19), the reason for worldwide pandemic, has already masked around 220 countries globally. This disease is induced by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). Arising environmental stress, increase in the oxidative stress level, weak immunity and lack of nutrition deteriorates the clinical status of the infected patients. Though several researches are at its peak for understanding and bringing forward effective therapeutics, yet there is no promising solution treating this disease directly. Medicinal plants and their active metabolites have always been promising in treating many clinical complications since time immemorial. Mother nature provides vivid chemical structures, which act multi-dimensionally all alone or synergistically in mitigating several diseases. Their unique antioxidant and anti-inflammatory activity with least side effects have made them more effective candidate for pharmacological studies. These medicinal plants inhibit attachment, encapsulation and replication of COVID-19 viruses by targeting various signaling molecules such as angiotensin converting enzyme-2, transmembrane serine protease 2, spike glycoprotein, main protease etc. This property is re-examined and its potency is now used to improve the existing global health crisis. This review is an attempt to focus various antiviral activities of various noteworthy medicinal plants. Moreover, its implications as prophylactic or preventive in various secondary complications including neurological, cardiovascular, acute kidney disease, liver disease are also pinpointed in the present review. This knowledge will help emphasis on the therapeutic developments for this novel coronavirus where it can be used as alone or in combination with the repositioned drugs to combat COVID-19.

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“…Emphasising the fact that for COVID‐19 patients’ appropriate interventions and liver function repair is necessary. The chronic liver conditions also carry greater risk and adverse risk and needs special interventions 40 …”

Section: Introductionmentioning

confidence: 99%

Long‐term side effects and lingering symptoms post COVID‐19 recovery

Zarei¹,

Bose

Nouri‐Vaskeh

et al. 2021

Reviews in Medical Virology

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Summary Since the Coronavirus disease 2019 (COVID‐19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), our understanding regarding the pathophysiology and clinical manifestations of this disease have been improving. However, we still have limited data on long‐term effects and lingering symptoms of post COVID‐19 recovery. Despite predilection of COVID‐19 for lungs, multiple extra‐pulmonary manifestations appear in multiple organs and biological systems and with continued infection and recovery worldwide. It is necessary that clinicians provide patients with previous SARS‐CoV‐2 infection with expectations of long‐term effects during or after recovery from COVID‐19. Herein, we review the long‐term impact of COVID‐19 on different organ systems reported from different clinical studies. Understanding risk factors and signs and symptoms of long‐term consequences after recovery from COVID‐19 will allow for proper follow‐up and management of the disease post recovery.

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Impact of COVID‐19 in Liver Disease Progression

Cited by 42 publications

References 121 publications

Rapid Turn From Cirrhosis to Encephalopathy Following COVID-19 Infection: A Cautionary Tale

Rapid Turn From Cirrhosis to Encephalopathy Following COVID-19 Infection: A Cautionary Tale

Jeopardy of COVID-19: Rechecking the Perks of Phytotherapeutic Interventions

Long‐term side effects and lingering symptoms post COVID‐19 recovery

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