2015
DOI: 10.1371/journal.pone.0127660
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Impact of Chronic Periodontitis on Levels of Glucoregulatory Biomarkers in Gingival Crevicular Fluid of Adults with and without Type 2 Diabetes

Abstract: The relationship between diabetes and periodontal disease is bidirectional, but information about the effect of chronic periodontitis on the levels of the glucoregulatory biomarkers locally in gingival crevicular fluid (GCF) is limited. The aim of this study was to compare the levels of 10 glucoregulatory biomarkers in GCF, firstly in subjects with type 2 diabetes (T2DM) presenting with and without chronic periodontitis and secondly, in subjects without diabetes, with and without chronic periodontitis. The mat… Show more

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Cited by 34 publications
(36 citation statements)
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“…in individuals without diabetes type 2. In that study the BMI was not reported . In serum no statistically significant difference was found, which is in contrast to the findings by Yilmaz et al .…”
Section: Discussioncontrasting
confidence: 83%
See 2 more Smart Citations
“…in individuals without diabetes type 2. In that study the BMI was not reported . In serum no statistically significant difference was found, which is in contrast to the findings by Yilmaz et al .…”
Section: Discussioncontrasting
confidence: 83%
“…Interestingly, elevated total and acylated ghrelin levels were found in the serum of patients with chronic periodontitis . Furthermore, the levels of ghrelin in gingival crevicular fluid were higher in patients with periodontitis and type 2 diabetes compared with periodontally healthy controls with type 2 diabetes, but lower in patients with periodontitis than in periodontally healthy controls when diabetes was absent …”
Section: Introductionmentioning
confidence: 99%
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“…Mohamed et al. () found that gastric inhibitory polypeptide (GIP), glucagon‐like peptide‐1 (GLP‐1) and glucagon were significantly upregulated in diabetic patients with chronic periodontitis compared with diabetes patients only. The same study found that the number of sites with pocket depth >4 mm correlated positively with GIP.…”
Section: Resultsmentioning
confidence: 99%
“…Mohamed et al reported a positive correlation between PD and GCF visfatin levels (34). Visfatin levels were also increased in the saliva following periodontal inflammation (35,36).…”
Section: Discussionmentioning
confidence: 98%