Impact of c-erbB-2 Protein on 5-year Survival Rate of Gastric Cancer Patients after Surgery: A Cohort Study and Meta-analysis

Wu, Hao; Cai, Zhengdong; Lu, Guangrong; Cao, Shuguang; Huang, He; Jiang, Yi; Sun, Weijian

doi:10.5301/tj.5000444

Cited by 10 publications

(7 citation statements)

References 41 publications

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“…The initial diagnosis rate is less than 10%. The 5-year survival rate is approximately 20% ( Wu et al, 2017 ). Early detection and treatment are critical for improving the survival rate of patients.…”

Section: Introductionmentioning

confidence: 99%

Association of multiple tumor markers with newly diagnosed gastric cancer patients: a retrospective study

Zhang

et al. 2022

PeerJ

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Background The purpose of this paper was to explore the correlation between multiple tumor markers and newly diagnosed gastric cancer. Methods We selected 268 newly diagnosed patients with gastric cancer and 209 healthy subjects for correlation research. The detection of multiple tumor markers was based on protein chips and the results were statistically analyzed using SPSS. Results We concluded that gastric cancer was significantly related to gender, age, alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199), and carbohydrate antigen 242 (CA242) positive levels (P < 0.001). After CA199 and CA242 were stratified by gender, the male odds ratio (OR) was 30.400 and 31.242, respectively, while the female OR was 3.424. After CA125 was stratified by age in patients over 54 years old with gastric cancer, the risk of occurrence in the CA125-positive population was 16.673 times that of the CA125-negative patients. Among patients 54 years old and younger, being CA125-positive was not a risk factor for gastric cancer (P = 0.082). AFP, CEA, CA125, CA199, and CA242 positive levels during the M1 stage were statistically significant when compared with the M0 stage and control group (P < 0.001), but the AFP (P = 0.045) and CA125 (P = 0.752) positive levels were not statistically significant when compared with the M0 stage and control group. The combined detection sensitivity of multiple tumor markers was 44.78%. Conclusion Our research shows that gastric cancer is associated with age, gender, and the positive levels of AFP, CEA, CA125, CA199, and CA242. The positive levels of AFP and CA125 were related to the distant metastasis of gastric cancer. To a certain extent, the combined detection sensitivity can be used for the initial screening of gastric cancer.

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Section: Introductionmentioning

confidence: 99%

Association of multiple tumor markers with newly diagnosed gastric cancer patients: a retrospective study

Zhang

et al. 2022

PeerJ

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“…After resection, 50–90% of patients still suffer recurrence and death. The 5-year survival rate is about 30% [3-5]. Therefore, the early diagnosis of GC, which is still difficult with the current technical means, is very important.…”

Section: Introductionmentioning

confidence: 99%

Enhanced LINC01061 Levels as a Serum Biomarker in Gastric Cancer and Promotion of Malignant Transformation

et al. 2021

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Background: The genomic copy number of LINC01061 is amplified in papillary thyroid cancer. However, its role in gastric cancer is not clear. Materials and Methods: Tissues and serum of GC patients were collected to detect the expression of LINC01061 by quantitative real-time polymerase chain reaction (qRT-PCR). ShRNA were applied to knock down the expression of LINC01061. Growth curves and colony formation experiments were applied to evaluate cell growth. Cell migration was assessed by transwell migration experiments. Cell cycle and apoptosis were analyzed by flow cytometry. Epithelial-mesenchymal transition (EMT) was examined by qRT-PCR and Western blot. Results: The expression of LINC01061 was upregulated in tissues and serum of GC patients and it was associated with the clinicopathological features and survival time. Functional study indicated that cell growth and migration were suppressed after LINC01061 knockdown. Cell cycle arrest and increased apoptosis occurred when LINC01061 expression was inhibited. EMT was also impaired combined with a decrease in β-catenin expression after LINC01061 knockdown. Conclusions: Our data indicate that LINC01061 is a novel biomarker for diagnosis and prognosis of GC. LINC01061 promoted progression of GC through cell cycle regulation and EMT.

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“…The initial diagnosis rate is less than 10%. The 5-year survival rate is approximately 20% [3]. Early detection and treatment are critical factors in the cure of gastric cancer, which can improve the survival rate of patients.…”

Section: Introductionmentioning

confidence: 99%

Association of Multiple Tumor Markers With Gastric Cancer Patients

Zhang

et al. 2021

Preprint

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Background: To explore the correlation between multiple tumor markers and gastric cancer.Methods: We selected 268 newly-treated patients with gastric cancer and 209 healthy subjects for correlation research. The detection of multiple tumor markers was based on protein chip, and then the results were statistically analyzed by SPSS.Results: (1)We concluded that gastric cancer was significantly related to gender, age, AFP, CEA, CA125, CA199, and CA242 (P＜0.001). After CA199 and CA242 were stratified by gender, the OR of the male was 30.400 and 31.242 respectively, while the OR of the female was 3.424. After CA125 was stratified by age, among patients with gastric cancer over 54 years old, The risk of occurrence in the CA125-positive population was 16.673 times that in CA125-negative patient; and among patients less than or equal to 54 years old, CA125-positive was not a risk factor for gastric cancer(P=0.082); (2)AFP, CEA, CA125, CA199, CA242 in M1 stage were statistically significant compared with M0 stage and control group (P<0.001), but AFP (P=0.045) and CA125 (P=0.752) were not statistically significant compared with M0 stage and control group; (3)The combined detection sensitivity of multiple tumor markers were 41.79%.Conclusions: Our research shows that gastric cancer is associated with age, gender, and the positive of AFP, CEA, CA125, CA199, and CA242. The positive of AFP and CA125 is related to the distant metastasis of gastric cancer; The combined detection of multiple tumor markers can be used for initial screening of gastric cancer to a certain extent.

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Impact of c-erbB-2 Protein on 5-year Survival Rate of Gastric Cancer Patients after Surgery: A Cohort Study and Meta-analysis

Abstract: Our study demonstrated that high expression of c-erbB-2 protein was strongly associated with lymph node metastasis, histological differentiation and 5-year survival rate in GC patients after surgery.

Cited by 10 publications

References 41 publications

Association of multiple tumor markers with newly diagnosed gastric cancer patients: a retrospective study

Association of multiple tumor markers with newly diagnosed gastric cancer patients: a retrospective study

Enhanced LINC01061 Levels as a Serum Biomarker in Gastric Cancer and Promotion of Malignant Transformation

Association of Multiple Tumor Markers With Gastric Cancer Patients

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