Association of multiple tumor markers with newly diagnosed gastric cancer patients: a retrospective study

Li, Xiaoyang; Li, Sifeng; Zhang, Zhenqi; Huang, Dandan

doi:10.7717/peerj.13488

Cited by 13 publications

(9 citation statements)

References 32 publications

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“…In many cases, tumor-related biomarkers are also associated with certain tumor pathological parameters 20,21 . When assessing the correlative relationships between PIC, TAT, TM, and t-PAIC levels and tumor stage, vascular invasion, lymph node metastasis, maximum tumor diameter, nerve invasion, and differentiation degree in patients bearing malignant tumors, we had found that TM was positive correlation with vascular invasion.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Coagulation and Fibrinolytic Markers Offer Utility when Distinguishing Between Benign and Malignant Gallbladder Tumors: A Cross-sectional Study

Huang,

Fan,

Hao

et al. 2024

Preprint

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Background The metabolic or proliferative abnormalities characteristic of tumor cells can result in aberrant fibrinolysis or coagulation system activity, with certain tumors exhibiting hypercoagulability or existing in a fibrinolytic state. The utility of biomarkers of coagulation and fibrinolysis when seeking to differentiate between benign gallbladder disease and malignant gallbladder tumors, however, remains uncertain. Methods In total, 81 diagnosed with benign gallbladder hyperplasia and 94 patients diagnosed with benign gallbladder hyperplasia and malignant gallbladder tumors in this study. Pre-biopsy or pretreatment PIC, TAT, TM, and t-PAIC levels from these patients were analyzed, and correlations between these biomarkers and patient clinicopathological parameters were assessed. Age and data of four biomarkers were compared using Mann-Whitney tests and the diagnostic utility of these biomarkers when distinguishing between benign and malignant lesions was evaluated using ROC curves. Chi-square test was used to compare the frequencies. Results The average age of malignant group was higher than benign group. And the base line analysis showed that there was a statistic difference in age, history of smoking, drinking, biliary tract disease, BMI of over weight between benign and malignant groups. In patients with malignant gallbladder tumors, PIC, TAT, TM, and t-PAIC levels were significantly elevated relative to those in patients affected by gallbladder benign hyperplasia. The AUC for four biomarker combined diagnosed, PIC, TAT, TM, t-PAIC was 0.8859, 0.8455, 0.6554, 0.7130, and 0.6806. All these indices offered significant predictive utility, with four biomarker combined diagnosed and PIC exhibiting higher level of significance. TM was correlated with the vascular invasion of patients bearing tumors, and TAT, t-PAIC was correlated with the nerve invasion of patients bearing tumors. Conclusions Relative to patients affected by benign gallbladder hyperplasia, cholangiocarcinoma and gallbladder cancer patients presented with significantly higher plasma PIC, TAT, TM, and t-PAIC concentrations, with four biomarkers combined and PIC offering noteworthy diagnostic potential. These four markers could be used to some degree to aid in the differentiation between benign and malignant gallbladder conditions, and predicting the risk of vascular metastasis and nerve metastasis.

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Section: Discussionmentioning

confidence: 99%

RETRACTED: Coagulation and Fibrinolytic Markers Offer Utility when Distinguishing Between Benign and Malignant Gallbladder Tumors: A Cross-sectional Study

Huang,

Fan,

Hao

et al. 2024

Preprint

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“…Ma et al [ 26 ] found that CEA is an independent prognostic factor in patients with GC, and the establishment of a CNLR prognostic scoring system combined with CEA and neutrophil-lymphocyte ratio can accurately predict the 3-year and 5-year survival rates of patients with GC. It has also been pointed out that the incidence of GC is significantly correlated with gender, age, CEA, alpha-fetoprotein (AFP), CA125, CA199 and CA242 positive levels, and AFP, CEA, CA125, CA199 and CA242 positive levels are significantly higher in M1 GC patients than in M0 patients[ 27 ]. Wang et al [ 28 ] compared the serum CA724 levels between patients with benign gastric lesions and patients with GC, and the results showed that the expression of CA724 in the serum of patients with GC was significantly increased, and the area under the curve of serum CA724 in the diagnosis of GC was 0.849, with high sensitivity and specificity in differentiating GC, which is an important indicator for early screening and auxiliary diagnosis of GC.…”

Section: Discussionmentioning

confidence: 99%

Carcinoembryonic antigen, carbohydrate antigen 199 and carbohydrate antigen 724 in gastric cancer and their relationship with clinical prognosis

Wang¹,

Zuo²,

Zhang³

et al. 2023

World J Gastrointest Oncol

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Colitis-associated colorectal cancer (CAC) is defined as a specific cluster of colorectal cancers that develop as a result of prolonged colitis in patients with inflammatory bowel disease (IBD). Patients with IBD, including ulcerative colitis and Crohn’s disease, are known to have an increased risk of developing CAC. Although the incidence of CAC has significantly decreased over the past few decades, individuals with CAC have increased mortality compared to individuals with sporadic colorectal cancer, and the incidence of CAC increases with duration. Chronic inflammation is generally recognized as a major contributor to the pathogenesis of CAC. CAC has been shown to progress from colitis to dysplasia and finally to carcinoma. Accumulating evidence suggests that multiple immune-mediated pathways, DNA damage pathways, and pathogens are involved in the pathogenesis of CAC. Over the past decade, there has been an increasing effort to develop clinical approaches that could help improve outcomes for CAC patients. Colonoscopic surveillance plays an important role in reducing the risk of advanced and interval cancers. It is generally recommended that CAC patients undergo endoscopic removal or colectomy. This review summarizes the current understanding of CAC, particularly its epidemiology, mechanisms, and management. It focuses on the mechanisms that contribute to the development of CAC, covering advances in genomics, immunology, and the microbiome; presents evidence for management strategies, including endoscopy and colectomy; and discusses new strategies to interfere with the process and development of CAC. These scientific findings will pave the way for the management of CAC in the near future.

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“…Albumin to Fibrinogen Ratio, The hemoglobin, albumin, lymphocyte, and platelet score, multiple tumor markers, increased expression of Histone Deacetylase 5 appear to be useful parameters in predicting orignostic expectancy in gastric tumors. [22][23][24][25] In 2017, the American Joint Committee on Cancer made revisions on cTNM staging system in their 8th Edition. [11] The staging system of American Joint Committee on Cancer only takes the number of positive lymph nodes into consideration but not the positive to total lymph node ratio.…”

Section: Discussionmentioning

confidence: 99%

Positive lymph node ratio as a prognostic factor for gastric cancer patients: Is it going to supersede positive lymph node number in guidelines?

et al. 2023

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Gastric malignancies constitute the sixth most common cancer with regards to incidence and have the fifth most mortality rates. Extended lymph-node dissection is the surgical modality of choice while treating advanced stage gastric cancer. It is yet a topic of debate, whether or not the amount of positive lymph nodes after a pathological examination following the surgical intervention is of prognostic value. In this study, it is aimed to evaluate the prognostic significance of positive lymph nodes following the surgery. A total of 193 patients who underwent curative gastrectomy between January 2011 and December 2015 have been considered for a retrospective data collection. The cases with R1-R2 resections, palliative or emergent surgeries are excluded. Metastatic to total number of lymph nodes, corresponded a ratio which was analyzed in this survey and practiced as a predictive parameter of disease outcome. This survey includes 138 male (71.5%) and 55 female (28.5%) patients treated between 2011 and 2015 in our clinic. The survey follow-up duration of the cases range between 0, 2, and 72 months, corresponding an average of 23.24 ± 16.99 months. We calculated cutoff value of 0.09 with, sensitivity is 76.32% for positive to total number of lymph nodes ratio, whereas specivity applies for 64.10%, positive predictive value for 58% and negative predictive value for 80.6%. Positive lymph node ratio has a prognostic value in terms of predicting the prognosis of the patients with gastric adenocarcinoma following a curative gastrectomy. This might in long term contribute to the prognostic analysis of patients if integrated in the current staging system.

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Association of multiple tumor markers with newly diagnosed gastric cancer patients: a retrospective study

Cited by 13 publications

References 32 publications

RETRACTED: Coagulation and Fibrinolytic Markers Offer Utility when Distinguishing Between Benign and Malignant Gallbladder Tumors: A Cross-sectional Study

RETRACTED: Coagulation and Fibrinolytic Markers Offer Utility when Distinguishing Between Benign and Malignant Gallbladder Tumors: A Cross-sectional Study

Carcinoembryonic antigen, carbohydrate antigen 199 and carbohydrate antigen 724 in gastric cancer and their relationship with clinical prognosis

Positive lymph node ratio as a prognostic factor for gastric cancer patients: Is it going to supersede positive lymph node number in guidelines?

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