Association of Multiple Tumor Markers With Gastric Cancer Patients

Abstract

Background: To explore the correlation between multiple tumor markers and gastric cancer.Methods: We selected 268 newly-treated patients with gastric cancer and 209 healthy subjects for correlation research. The detection of multiple tumor markers was based on protein chip, and then the results were statistically analyzed by SPSS.Results: (1)We concluded that gastric cancer was significantly related to gender, age, AFP, CEA, CA125, CA199, and CA242 (P＜0.001). After CA199 and CA242 were stratified by gender, the OR of the male was 30.400 and 31.242 respectively, while the OR of the female was 3.424. After CA125 was stratified by age, among patients with gastric cancer over 54 years old, The risk of occurrence in the CA125-positive population was 16.673 times that in CA125-negative patient; and among patients less than or equal to 54 years old, CA125-positive was not a risk factor for gastric cancer(P=0.082); (2)AFP, CEA, CA125, CA199, CA242 in M1 stage were statistically significant compared with M0 stage and control group (P<0.001), but AFP (P=0.045) and CA125 (P=0.752) were not statistically significant compared with M0 stage and control group; (3)The combined detection sensitivity of multiple tumor markers were 41.79%.Conclusions: Our research shows that gastric cancer is associated with age, gender, and the positive of AFP, CEA, CA125, CA199, and CA242. The positive of AFP and CA125 is related to the distant metastasis of gastric cancer; The combined detection of multiple tumor markers can be used for initial screening of gastric cancer to a certain extent.