Impact of an inflammation-based prognostic system on patients undergoing surgery for hepatocellular carcinoma: a retrospective study of 398 Japanese patients

Ishizuka, Mitsuru; Kubota, Keiichi; Kita, Junji; Shimoda, Mitsugi; Kato, Masato; Sawada, Tokihiko

doi:10.1016/j.amjsurg.2010.09.030

Cited by 89 publications

(116 citation statements)

References 32 publications

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“…Albumin is 1 of the 2 components (together with CRP) of the Glasgow systemic inflammation index for cancer, an important and independent prognosticator for many cancers, including HCC (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Additionally, albumin, as part of the ALBI grading system, has been shown to be a quantitative, useful and prognostic indicator of liver dysfunction in HCC patients (21)(22)(23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

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Serum Albumin Levels in Relation to Tumor Parameters in Hepatocellular Carcinoma Patients

Carr

Guerra

2017

Int J Biol Markers

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ORIGINAL RESEARCH ARTICLEFurthermore, albumin values have been used in the 2-parameter albumin-bilirubin (ALBI) quantitative grading system for liver function in HCC, which has in turn been incorporated into several staging systems (21-25). There is thus much recent interest in serum albumin levels in prognostication, mainly as a reflection of liver function in HCC. However, there is also some direct experimental evidence that increased albumin levels can actually suppress HCC cell growth (26,27). Viewed this way, albumin levels may influence prognosis as much by their actions on HCC biology as by their reflection of impaired liver function.In this study, we examined the clinical correlations of serum albumin levels in a large HCC patient cohort with parameters of HCC behavior, and found an inverse relationship between serum albumin levels and HCC aggressiveness. Methods Patient dataWe retrospectively analyzed a prospectively collected database of 4,139 HCC patients, as previously reported (28,29), who had full baseline tumor parameter data, including computed axial tomography (CT) scan information on HCC size, number of tumor nodules and presence of PVT and plasma AFP levels; complete blood counts; routine blood liver function tests (total bilirubin, γ-glutamyl transpeptidase [GGT] and albumin); and patient demographics. Database management conformed to legislation on privacy, and this study conformed to the ethical guidelines of the Declaration of Helsinki. Approval for this retrospective study

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Section: Discussionmentioning

confidence: 99%

“…Indices of systemic inflammation have also been found to be independent cancer and HCC prognosticators (9)(10)(11)(12)(13)(14)(15)(16). A widely used inflammation index is the Glasgow Prognostic Score (15,16), which consists of 2 factors -namely, serum albumin and C-reactive protein (CRP) levels.…”

Section: Introductionmentioning

confidence: 99%

Serum Albumin Levels in Relation to Tumor Parameters in Hepatocellular Carcinoma Patients

Carr

Guerra

2017

Int J Biol Markers

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“…An inflammatory response to the tumor leads to tumor proliferation and metastasis due to inhibition of apoptosis and promotion of angiogenesis (27)(28)(29)(30). The GPS is a clinically useful inflammation-based prognostic scoring system for predicting the postoperative prognosis of the patients with colorectal cancer (9), esophageal cancer (10), bladder cancer (11), pancreatic head cancer (12), renal clear cell cancer (13), non-small cell lung cancer (14), and HCC (18,19). The GPS is evaluated using only serum CRP and serum albumin, which are common laboratory parameters for assessment of preand postoperative patients status.…”

Section: Discussionmentioning

confidence: 99%

“…We previously reported the GPS as a predictor of long-term therapeutic outcome for hepatobiliary malignancies, including carcinoma of the ampulla of Vater (15), gallbladder cancer (16), and unresectable colorectal cancer liver metastasis (17). However, there have been only few reports on the relationship between the GPS and long-term outcome after hepatic resection for HCC (18,19). In this study, we retrospectively evaluated whether the GPS predicts disease-free or overall survival after hepatic resection for HCC.…”

Section: Introductionmentioning

confidence: 99%

Glasgow prognostic score predicts therapeutic outcome after hepatic resection for hepatocellular carcinoma

Shiba¹,

Horiuchi²,

Sakamoto³

et al. 2017

Oncology Letters

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Abstract. Systemic inflammation, as evidenced by the Glasgow prognostic score (GPS), predicts cancer-specific survival in various cancer types. The aim of this study was to evaluate the significance of the GPS in the therapeutic outcome of the patient following surgical resection for hepatocellular carcinoma. In total, 144 patients underwent surgical resection for hepatocellular carcinoma. For the assessment of systemic inflammatory response using the GPS, patients were classified into three groups: Patients with normal serum albumin (<3.5 g/dl) and normal serum C-reactive protein (CRP) (≤1.0 mg/dl) were classified as GPS 0 (n=76), those with low serum albumin (<3.5 g/dl) or elevated serum CRP (>1.0 mg/dl) were classified as GPS 1 (n=58), and those with low serum albumin (<3.5 g/dl) and elevated serum CRP (>1.0 mg/dl) were classified as GPS 2 (n=10). Retrospectively, the relationship between patient characteristics including GPS, disease-free as well as overall survival were investigated. In disease-free survival, GPS 2 (P=0.019), with a tumor number ≥3 (P=0.004), and positive portal or venous invasion (P= 0.034) were independent predictors of cancer recurrence in multivariate analysis. In overall survival, GPS 1 (P= 0.042), GPS 2 (P<0.001) and positive portal or venous invasion (P<0.001) were independent predictors of poor patient outcome according to multivariate analysis. To conclude, the GPS in patients with hepatocellular carcinoma is an independent prognostic predictor after hepatic resection.

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“…These include the Glasgow Prognostic Score (GPS), which is based on serum CRP and albumin levels (22)(23)(24)(25)(26)(27)(28), neutrophil-to-lymphocyte ratio (NLR) (29,30), platelet-to-lymphocyte ratio (31,32), prognostic nutritional index (33,34), and prognostic index (34,35).…”

Section: Introductionmentioning

confidence: 99%

Glasgow Prognostic Score predicts prognosis of intrahepatic cholangiocarcinoma

Qin

Zhang

et al. 2017

Molecular and Clinical Oncology

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Abstract. High Glasgow Prognostic Score (GPS) has been associated with poor prognosis in patients with lung, ovarian, colorectal and renal cancer, as well as hepatocellular carcinoma. The aim of this study was to investigate the prognostic value of GPS in patients with intrahepatic cholangiocarcinoma (ICC) undergoing partial hepatectomy. A total of 72 patients with pathologically confirmed ICC were classified according to their GPS scores assigned based on the preoperative levels of C-reactive protein (CRP) and albumin. Their clinicopathological data were retrospectively assessed using univariate and multivariate analysis to determine their association with overall survival and recurrence. High GPS scores in ICC patients were associated with preoperative levels of CRP (P<0.001) and albumin (P<0.001), frequency of ascites accumulation (P=0.035), lymph node metastasis (P=0.002) and tumour size (P=0.005). On univariate analysis, preoperative levels of CRP (P<0.001), albumin (P=0.016) and carbohydrate antigen 19-9 (P=0.038), hepatitis B virus (HBV) positivity (P=0.009), occurrence of lymph node metastasis (P=0.001), Child-Pugh class B (P=0.013) and high tumour-node-metastasis (TNM) stage (P=0.002) were found to be associated with the 1-and 3-year overall survival. Multivariate analysis suggested that GPS score (HR=2.037, 95% CI: 1.092-3.799, P=0.025), TNM classification (HR=2.000, 95% CI: 1.188-3.367, P=0.009) and HBV positivity (HR=0.559 95% CI: 0.328-0.953, P=0.032) were independently associated with patient survival. High GPS scores also predicted ICC recurrence. In conclusion, our results demonstrated that GPS may serve as an independent marker of prognosis in patients with ICC following partial hepatectomy.

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Impact of an inflammation-based prognostic system on patients undergoing surgery for hepatocellular carcinoma: a retrospective study of 398 Japanese patients

Cited by 89 publications

References 32 publications

Serum Albumin Levels in Relation to Tumor Parameters in Hepatocellular Carcinoma Patients

Serum Albumin Levels in Relation to Tumor Parameters in Hepatocellular Carcinoma Patients

Glasgow prognostic score predicts therapeutic outcome after hepatic resection for hepatocellular carcinoma

Glasgow Prognostic Score predicts prognosis of intrahepatic cholangiocarcinoma

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