Impact of Aberrant Myeloid Antigen Expression on Outcomes of Patients with T-cell Acute Lymphoblastic Leukemia

Al-Zaabi, Mohamed; Al-Khabori, Murtadha; Fawaz, Naglaa; Al-Lamki, Sulayma; Al-Riyami, Arwa Z.; Al-Huneini, Mohammed; Al-Muslahi, Muhanna; Alkindi, Salam

doi:10.5001/omj.2017.36

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…In agreement with a previous study from Oman [29] , the current study includes more males than females, this results in agreement with the facts previously mentioned in most papers [30][31][32] .…”

Section: Discussionsupporting

confidence: 94%

Significance Aberrant Of CD133 Expression and Their Clinical Impact in Acute Lymphoblastic Leukemia among Sudanese Patients in Khartoum State

Atia

Hamid

Elkarsany

et al. 2021

ijirms

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Background: Acute lymphoblastic leukemia (ALL) is a malignant disease that arises from several genetic mutations in a single B- or T-lymphoid precursor, resulting in altered blast cell survival, proliferation, and maturation. Objectives: This current study was aimed to determine the significance of aberrant CD133 and 45 expressions in Sudanese Patients with Acute lymphoblastic Leukemia, and their clinical significance in Khartoum state. Materials and Methods: One hundred Sudanese participants were enrolled in this study as follows: 88 Patients diagnosed with ALL as a case and 12 healthy controls donors were randomly selected. 2.5-5 mL of EDTA blood/bone marrow for flowcytometry from each patient and controls subject. Results: Eighty-eight newly diagnosed Sudanese patients with acute lymphocytic leukemia (ALL) were involved in this study, their age average is (15.7) and their stander deviation (SD) is 17.4. The frequency of aberrant markers concerning control groups was significantly associated with all patients in CD 45 with a P value (0.0001), while there was no difference between cases and control in the frequency of CD 133 antigen, there was no significant difference between age groups in the expression of different aberrant antigens. The study was significantly more expressed CD133 in males than females. Also no significant difference in hematological parameters between patients with or without expression of Aberrant CD 45 and 133 markers, while we found significantly high TWBCs in T. cell leukemia. Conclusion: Aberrant myeloid antigens CD45 was significantly associated with childhood and adult ALL and may be considered as important prognostic factors, while CD 133 were not associated with ALL.

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Section: Discussionsupporting

confidence: 94%

Significance Aberrant Of CD133 Expression and Their Clinical Impact in Acute Lymphoblastic Leukemia among Sudanese Patients in Khartoum State

Atia

Hamid

Elkarsany

et al. 2021

ijirms

View full text Add to dashboard Cite

show abstract

“…In agreement with a previous study from Oman (27), the current study includes more males than females. This results in agreement with the facts that was previously mentioned in most papers (28)(29)(30).…”

Section: Discussionsupporting

confidence: 91%

Significance of aberrant CD82 expression and their Clinical Impact in Acute Lymphoblastic Leukemia among Sudanese Patients in Khartoum state

Attia¹,

Hamid²,

Mohamed³

et al. 2021

Frontiers in Scientific Research and Technology

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Acute lymphoblastic leukemia(ALL) is a malignant disease that arises from several genetic mutations in a single B-or T-lymphoid precursor. The risk of developing (ALL is more common in children younger than 5 years of age. Aberrant phenotype expression due to genetic defects may be associated with unfavorable outcomes. This study was aimed to determine the significance of aberrant CD82 and CD 45 expressions in Sudanese Patients with Acute lymphoblastic Leukemia, and their clinical significance in Khartoum state. Eghity-eight newly diagnosed patients with ALL were randomly selected as case groups, and 12 abberantly healthy controls. 3.0 ml of EDTA blood and other 3.0 ml of bone marrow aspirate was drawn from each patient and control subjects. The laboratory investigations included that were a Complete blood count by using Automated hematology analyzer and CD45 and CD82 marker detection by flowcytometer. All patients were Sudanese with acute lymphocytic leukemia (ALL), their average age was (15.7) and the stander deviation(SD) was (17.4±1.8). The frequency of the aberrant markers concerning control groups was significantly associated with patients in CD82 expression with a P value (0.001). Also significant association of expression of CD82 marker and presence of immature cells in B.cell leukemia was found with P value (0.016), while no difference between childhood (70.1%) and Adult (67.8%) in immature cell ratios. The current study confirms the previous studies in which aberrant antigens CD45 and CD82 were significantly associated with childhood and adult ALL and may be considered as important prognostic factors.

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Impact of Aberrant Myeloid Antigen Expression on Outcomes of Patients with T-cell Acute Lymphoblastic Leukemia

Abstract: Patients with T-ALL with myeloid antigen expression need more courses of induction; however, rates of CR, EFS, and OS are not different from those without myeloid antigen expression. Larger prospective studies are required to confirm these findings.

Cited by 2 publications

References 20 publications

Significance Aberrant Of CD133 Expression and Their Clinical Impact in Acute Lymphoblastic Leukemia among Sudanese Patients in Khartoum State

Significance Aberrant Of CD133 Expression and Their Clinical Impact in Acute Lymphoblastic Leukemia among Sudanese Patients in Khartoum State

Significance of aberrant CD82 expression and their Clinical Impact in Acute Lymphoblastic Leukemia among Sudanese Patients in Khartoum state

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