Significance of aberrant CD82 expression and their Clinical Impact in Acute Lymphoblastic Leukemia among Sudanese Patients in Khartoum state

Abstract

Acute lymphoblastic leukemia(ALL) is a malignant disease that arises from several genetic mutations in a single B-or T-lymphoid precursor. The risk of developing (ALL is more common in children younger than 5 years of age. Aberrant phenotype expression due to genetic defects may be associated with unfavorable outcomes. This study was aimed to determine the significance of aberrant CD82 and CD 45 expressions in Sudanese Patients with Acute lymphoblastic Leukemia, and their clinical significance in Khartoum state. Eghity-eight newly diagnosed patients with ALL were randomly selected as case groups, and 12 abberantly healthy controls. 3.0 ml of EDTA blood and other 3.0 ml of bone marrow aspirate was drawn from each patient and control subjects. The laboratory investigations included that were a Complete blood count by using Automated hematology analyzer and CD45 and CD82 marker detection by flowcytometer. All patients were Sudanese with acute lymphocytic leukemia (ALL), their average age was (15.7) and the stander deviation(SD) was (17.4±1.8). The frequency of the aberrant markers concerning control groups was significantly associated with patients in CD82 expression with a P value (0.001). Also significant association of expression of CD82 marker and presence of immature cells in B.cell leukemia was found with P value (0.016), while no difference between childhood (70.1%) and Adult (67.8%) in immature cell ratios. The current study confirms the previous studies in which aberrant antigens CD45 and CD82 were significantly associated with childhood and adult ALL and may be considered as important prognostic factors.