IMP3 promotes re‐endothelialization after arterial injury via increasing stability of VEGF mRNAhv

Abstract

Coronary angioplasty and stents implantation are widely used surgical techniques for restoring blood flow to the coronary arteries; it is done by mechanically widening the narrowed or blocked segments of the artery to alleviate myocardial ischemia. Although the use of bare metal stents (BMS) in most procedures of myocardial revascularization were effective in reversing acute vessel closures, whilst lowering risks of coronary complications, at the same time, stenting procedures were frequently plagued with neointimal hyperplasia and in-stent restenosis 1 post-surgery, as a result of excessive vascular healing in response to stent-related injuries. More recently, drug-eluting stents (DES) were introduced as a safer, more effective alternative to BMS, with statistically superior performance and