Biological significance of METTL5 in atherosclerosis: comprehensive analysis of single-cell and bulk RNA sequencing data

Wu, Jianjin; Wang, Lei; Xi, Shuaishuai; Ma, Chao; Zou, Fukang; Fang, Guanyu; Liu, Fangbing; Wang, Xiaokai; Qu, Lefeng

doi:10.18632/aging.205755

Aging

2024

DOI: 10.18632/aging.205755

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Biological significance of METTL5 in atherosclerosis: comprehensive analysis of single-cell and bulk RNA sequencing data

Jianjin Wu,

Lei Wang,

Shuaishuai Xi

et al.

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METTL Family in Health and Disease

He,

Hao,

Song

et al. 2024

Mol Biomed

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Transcription, RNA splicing, RNA translation, and post-translational protein modification are fundamental processes of gene expression. Epigenetic modifications, such as DNA methylation, RNA modifications, and protein modifications, play a crucial role in regulating gene expression. The methyltransferase-like protein (METTL) family, a constituent of the 7-β-strand (7BS) methyltransferase subfamily, is broadly distributed across the cell nucleus, cytoplasm, and mitochondria. Members of the METTL family, through their S-adenosyl methionine (SAM) binding domain, can transfer methyl groups to DNA, RNA, or proteins, thereby impacting processes such as DNA replication, transcription, and mRNA translation, to participate in the maintenance of normal function or promote disease development. This review primarily examines the involvement of the METTL family in normal cell differentiation, the maintenance of mitochondrial function, and its association with tumor formation, the nervous system, and cardiovascular diseases. Notably, the METTL family is intricately linked to cellular translation, particularly in its regulation of translation factors. Members represent important molecules in disease development processes and are associated with patient immunity and tolerance to radiotherapy and chemotherapy. Moreover, future research directions could include the development of drugs or antibodies targeting its structural domains, and utilizing nanomaterials to carry miRNA corresponding to METTL family mRNA. Additionally, the precise mechanisms underlying the interactions between the METTL family and cellular translation factors remain to be clarified.

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METTL Family in Health and Disease

He,

Hao,

Song

et al. 2024

Mol Biomed

View full text Add to dashboard Cite

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Biological significance of METTL5 in atherosclerosis: comprehensive analysis of single-cell and bulk RNA sequencing data

Cited by 1 publication

References 32 publications

METTL Family in Health and Disease

METTL Family in Health and Disease

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