Immunotherapy for Cancer: Effects of Iron Oxide Nanoparticles on Polarization of Tumor-Associated Macrophages

Nascimento, Camila Sales; Alves, Érica Alessandra Rocha; Melo, Celso P. de; Corrêa-Oliveira, Rodrigo; Calzavara-Silva, Carlos Eduardo

doi:10.2217/nnm-2021-0255

Cited by 31 publications

(34 citation statements)

References 98 publications

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“…Liposome-Encapsulated CpG (cytosine-phosphorothioate-guanine) Oligodeoxynucleotides (CpG-ODNs) exhibit potent immunostimulating activity by binding with Toll-like receptor 9 (TLR9) expressed on DC cells and activating NK cells, NKT cells and enhance expression of the early activation molecule CD69 on conventional T cells ( 156 ). Iron oxide nanoparticles also can simultaneously promote the reprogramming of tumor-associated macrophages to a pro-inflammatory profile and effectively deliver the ovalbumin antigen (OVA) to dendritic cells and activate both CD4+ and CD8+ antigen-specific T effector cells is achieved for powerful antitumor effects in female C57/BL6 mice injected with EG7-OVA cells (mouse lymphoma cell line) ( 157 , 158 ).…”

Section: Immunotherapy Based On Nanotechnologymentioning

confidence: 99%

The role of T-cells in head and neck squamous cell carcinoma: From immunity to immunotherapy

et al. 2022

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Head and neck squamous cell carcinoma (HNSCC) encompass a group of complex entities of tumours affecting the aerodigestive upper tract. The main risk factors are strongly related to tobacco and alcohol consumption, but also HPV infection is often associated. Surgery, radiotherapy and/or chemotherapy are the standard treatments, though the 5-year overall survival is less than 50%. The advances in genomics, molecular medicine, immunology, and nanotechnology have shed a light on tumour biology which helps clinical researchers to obtain more efficacious and less toxic therapies. Head and neck tumours possess different immune escape mechanisms including diminishing the immune response through modulating immune checkpoints, in addition to the recruitment and differentiation of suppressive immune cells. The insights into the HNSCC biology and its strong interaction with the tumour microenvironment highlights the role of immunomodulating agents. Recently, the knowledge of the immunological features of these tumours has paved the way for the discovery of effective biomarkers that allow a better selection of patients with odds of improving overall survival through immunotherapy. Specially biomarkers regarding immune checkpoint inhibitors antibodies, such as anti-PD-1/PD-L1 and anti-CTLA-4 in combination with standard therapy or as monotherapy. New immunotherapies to treat head and neck cancer carcinomas, such as CAR T cells and nanoparticles have been the center of attention and in this review, we discuss the necessity of finding targets for the T cell in the cancer cells to generate CAR T cells, but also the relevance of evaluating specificity and safety of those therapies.

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Section: Immunotherapy Based On Nanotechnologymentioning

confidence: 99%

The role of T-cells in head and neck squamous cell carcinoma: From immunity to immunotherapy

et al. 2022

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“…Furthermore, we sought to broaden our understanding of the mechanisms of iron oxide-based macrophage repolarization and tumor inhibition. Fenton reaction has been considered as the innate reason for macrophage conversion and ROS is one significant production mediated the process [ 16 , 46 ]. Thus, we examined the ROS releasing from macrophages and found that HA-man@Fe 3 O 4 induced the highest ROS amount in all iron oxide-treated groups, corresponding to the strongest skewing effect shown in flow cytometry and ELISA assay ( Figure 3 A–H).…”

Section: Discussionmentioning

confidence: 99%

Mannose and Hyaluronic Acid Dual-Modified Iron Oxide Enhances Neoantigen-Based Peptide Vaccine Therapy by Polarizing Tumor-Associated Macrophages

Nie

Shi

Zhang

et al. 2022

Cancers

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Neoantigen-based cancer vaccine therapy is a breakthrough in the field of immunotherapy. However, it is difficult for vaccines against neoantigens to overcome the immunosuppressive microenvironment, where tumor-associated macrophages (TAMs) play a significant role. Herein, we report an iron oxide nanoparticle modified with hyaluronic acid and mannose to reshape the tumor microenvironment by targeting and repolarizing TAMs from protumor M2 to antitumor M1 phenotype. Mannose decoration could confer the nanoparticle-enhanced TAM targeting ability, while hyaluronic acid and iron oxide could repolarize M2-like macrophages both in vitro and in vivo. Combined with antigenic peptides, this nanovaccine could significantly increase the infiltration of CD8+ T cells into tumor tissue and strongly activate dendritic cells in sentinel lymph nodes. Finally, we used the dual-modified nanoparticles to first convert the tumor microenvironment and then the nanovaccine administration in a TC1 tumor model to further enhance efficacy. This strategy inhibited tumor growth and achieved a 40% cure rate in mice (two of five). In summary, this study provides a potent and rationally designed nanoadjuvant to enhance antitumor efficiency and facilitate delivery of neoantigen vaccines by repolarizing TAMs and harmonizing immune cells.

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“…Phagocytosis of NPs can influence TAM polarization because these particles are recognized as foreign bodies. IONPs demonstrated a potent effect on TAM polarization due to iron transporter-related protein expression [ 311 , 312 , 313 ]. Kodali et al [ 314 ] reported 1029 changes in gene expression of lung macrophages using IONPs while silica NPs with only 67 gene.…”

Section: Interaction Of Mnps With Biological Systemmentioning

confidence: 99%

Smart and Multi-Functional Magnetic Nanoparticles for Cancer Treatment Applications: Clinical Challenges and Future Prospects

et al. 2022

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Iron oxide nanoparticle (IONPs) have become a subject of interest in various biomedical fields due to their magnetism and biocompatibility. They can be utilized as heat mediators in magnetic hyperthermia (MHT) or as contrast media in magnetic resonance imaging (MRI), and ultrasound (US). In addition, their high drug-loading capacity enabled them to be therapeutic agent transporters for malignancy treatment. Hence, smartening them allows for an intelligent controlled drug release (CDR) and targeted drug delivery (TDD). Smart magnetic nanoparticles (SMNPs) can overcome the impediments faced by classical chemo-treatment strategies, since they can be navigated and release drug via external or internal stimuli. Recently, they have been synchronized with other modalities, e.g., MRI, MHT, US, and for dual/multimodal theranostic applications in a single platform. Herein, we provide an overview of the attributes of MNPs for cancer theranostic application, fabrication procedures, surface coatings, targeting approaches, and recent advancement of SMNPs. Even though MNPs feature numerous privileges over chemotherapy agents, obstacles remain in clinical usage. This review in particular covers the clinical predicaments faced by SMNPs and future research scopes in the field of SMNPs for cancer theranostics.

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Immunotherapy for Cancer: Effects of Iron Oxide Nanoparticles on Polarization of Tumor-Associated Macrophages

Cited by 31 publications

References 98 publications

The role of T-cells in head and neck squamous cell carcinoma: From immunity to immunotherapy

The role of T-cells in head and neck squamous cell carcinoma: From immunity to immunotherapy

Mannose and Hyaluronic Acid Dual-Modified Iron Oxide Enhances Neoantigen-Based Peptide Vaccine Therapy by Polarizing Tumor-Associated Macrophages

Smart and Multi-Functional Magnetic Nanoparticles for Cancer Treatment Applications: Clinical Challenges and Future Prospects

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