Immunotherapeutic effect of the lactobacillus vaccine, Solco Trichovac, in trichomoniasis is not mediated by antibodies cross reacting with Trichomonas vaginalis.

Gombosová, A; Demĕs, P; Valent, M

doi:10.1136/sti.62.2.107

Cited by 13 publications

(9 citation statements)

References 8 publications

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“…Given these facts, it is unlikely that any trichomonidical activity of SolcoTrichovac was the result of a direct immune or antibody response to T. vaginalis. It is more likely that vaccination stimulated an increase in nonspecific immune factors capable of alleviating symptoms and eliminating infection (9,39).…”

Section: Vaccinesmentioning

confidence: 99%

Treatment of Infections Caused by Metronidazole-ResistantTrichomonas vaginalis

et al. 2004

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Infections with the sexually transmitted protozoan Trichomonas vaginalis are usually treated with metronidazole, a 5-nitroimidazole drug derived from the antibiotic azomycin. Metronidazole treatment is generally efficient in eliminating T. vaginalis infection and has a low risk of serious side effects. However, studies have shown that at least 5% of clinical cases of trichomoniasis are caused by parasites resistant to the drug. The lack of approved alternative therapies for T. vaginalis treatment means that higher and sometimes toxic doses of metronidazole are the only option for patients with resistant disease. Clearly, studies of the treatment and prevention of refractory trichomoniasis are essential. This review describes the mechanisms of metronidazole resistance in T. vaginalis and provides a summary of trichomonicidal and vaccine candidate drugs

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Section: Vaccinesmentioning

confidence: 99%

Treatment of Infections Caused by Metronidazole-ResistantTrichomonas vaginalis

et al. 2004

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“…In field trials using heat-inactivated Trichomonas vaginalis vaccine prepared from inactivated lactobacilli and administered intravaginally, persistently infected women were clinically cured (Aburel et al 1963;Milovanovic et al 1983;Gombosova et al 1986;Demes et al 1985;Cudmore and Garber 2010). However, lack of antigenic similarity between the vaccine and Trichomonas vaginalis was reported (Alderete 1988) while other trials with the vaccine were inconclusive (Guerrero et al 1987).…”

Section: Immunization In Humansmentioning

confidence: 99%

Comparative aspects of immunity and vaccination in human and bovine trichomoniasis: a review

Chapwanya

Usman

Irons

2015

Trop Anim Health Prod

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Trichomonas vaginalis and Tritrichomonas foetus are important extracellular protozoans that cause, respect i v e l y, h u m a n a n d b o v i n e v e n e r e a l d i s e a s e s . Trichomonads are extracellular parasites that primarily inhabit the genital tracts of the mammalian hosts where they overcome the mucus barrier and parasitize mucosa by contact-dependent or contact-independent cytotoxicity. Transient immunity is usually achieved by the host after clinical infection. At present, vaccination in cattle reduces infection rates and reproductive wastage in affected herds. After vaccination, immunoglobulin G (IgG) levels increase in systemic circulation while immunoglobulin A (IgA) levels rise in the vagina. Only moderate protection is conferred by means of vaccination. Future vaccine development strategies are needed for cattle to enhance the antigenic component or use adjuvant that strongly activates the innate immune response to produce safe and potent vaccines. This paper reviews the current knowledge of the immunology of trichomoniasis infection and the challenges and potential of vaccines in the control of the infection in human and bovine trichomoniasis.

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“…Lactobacillus rhamnosus GG, a well‐known probiotic, was found to synergize with antiviral antibodies and helped in early recovery from diarrhea in mice, saving up to 90% of antibodies. Lactobacillus casei GG isolated from human samples, now popularly known as L. rhamnosus , has been used in Finland for recovery from acute rotavirus diarrhea in children (Gomboova et al , 1986). The probiotic is given in the form of powder or as a fermented milk product.…”

Section: Infantile Diarrheamentioning

confidence: 99%

Probiotics: multifarious oral vaccine against infectious traumas

Amdekar

Dwivedi

Roy

et al. 2010

FEMS Immunol Med Microbiol

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Microorganisms have been used for a long time in food and alcoholic fermentation. In the last few years they have undergone scientific scrutiny of their preventative and therapeutic aspects. This has led to the discovery of a new term, probiotics. Lactic acid bacteria (LAB) are microbial communities normally present in the intestine of most animals. They play an important role in humans and other animals, and act as immunomodulators. They are helpful in the treatment and prevention of disease as well as improving the digestion and absorption of nutrients. Probiotic microorganisms include the LAB Lactobacillus acidophilus, Lactobacillus bulgaricus, Lactobacillus casei, Lactobacillus plantarum and Lactobacillus rhamnosus. Use of these live bacteria to elicit an immune response or to carry a vaccine component is a new invention in vaccine development. The advantage of live bacterial vaccines is that they mimic natural infection, have intrinsic adjuvant properties and can be given orally. Components of pathogenic and nonpathogenic food-related microorganisms are currently being evaluated as candidates for oral vaccines.

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Immunotherapeutic effect of the lactobacillus vaccine, Solco Trichovac, in trichomoniasis is not mediated by antibodies cross reacting with Trichomonas vaginalis.

Cited by 13 publications

References 8 publications

Treatment of Infections Caused by Metronidazole-ResistantTrichomonas vaginalis

Treatment of Infections Caused by Metronidazole-ResistantTrichomonas vaginalis

Comparative aspects of immunity and vaccination in human and bovine trichomoniasis: a review

Probiotics: multifarious oral vaccine against infectious traumas

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