Probiotics: multifarious oral vaccine against infectious traumas

(2015) Lactobacillus acidophilus ATCC 4356 inhibits biofilm formation by C.albicans and attenuates the experimental candidiasis in Galleriamellonella, Virulence, 6:1, 29-39, DOI: 10.4161/21505594.2014 Probiotic strains of Lactobacillus have been studied for their inhibitory effects on Candida albicans. However, few studies have investigated the effect of these strains on biofilm formation, filamentation and C. albicans infection. The objective of this study was to evaluate the influence of Lactobacillus acidophilus ATCC 4356 on C. albicans ATCC 18804 using in vitro and in vivo models. In vitro analysis evaluated the effects of L. acidophilus on the biofilm formation and on the capacity of C. albicans filamentation. For in vivo study, Galleria mellonella was used as an infection model to evaluate the effects of L. acidophilus on candidiasis by survival analysis, quantification of C. albicans CFU/mL, and histological analysis. The direct effects of L. acidophilus cells on C. albicans, as well as the indirect effects using only a Lactobacillus culture filtrate, were evaluated in both tests. The in vitro results showed that both L. acidophilus cells and filtrate were able to inhibit C. albicans biofilm formation and filamentation. In the in vivo study, injection of L. acidophilus into G. mellonella larvae infected with C. albicans increased the survival of these animals. Furthermore, the number of C. albicans CFU/mL recovered from the larval hemolymph was lower in the group inoculated with L. acidophilus compared to the control group. In conclusion, L. acidophilus ATCC 4356 inhibited in vitro biofilm formation by C. albicans and protected G. mellonella against experimental candidiasis in vivo.

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“…13 These data suggest that the effect of Lactobacillus on C. albicans needs to be studied in vivo using host models of experimental infection.…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus acidophilus ATCC 4356 inhibits biofilm formation by C. albicans and attenuates the experimental candidiasis in Galleria mellonella

et al. 2015

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“…lactis is a potential candidate for the production of biologically useful proteins and application as an antigen delivery vehicle for the development of live mucosal vaccines (Anderson et al 2010). The advantage of live bacterial vaccines is that they mimic natural infection, have intrinsic adjuvant properties, and can be given orally (Amdekar et al 2010). …”

Section: Lab As Live Vaccinesmentioning

confidence: 99%

Functionality and Therapeutic Values of Fermented Foods

Thapa¹,

Tamang²

2015

Health Benefits of Fermented Foods and Beverages

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“…This is primarily achieved via mucosal antigen sampling by pattern recognition receptors (PRRs) expressed on intestinal epithelial cells and innate immune cells (Rautava and Walker, 2007). These specialized receptors bind to microbial-associated molecular patterns (MAMPs) that are expressed on a variety of commensal micro-organisms (Amdekar et al, 2010). An important member of the PRRs is the Toll-like receptors (TLR) that recognize a range of MAMPS such as lipoteichoic acid (TLR2) and lipopolysaccharide (TLR4) on Gram-negative and Gram-positive bacteria, respectively (Bauer et al, 2007).…”

Section: Hygiene Hypothesis Intestinal Microbiota and Immune Develomentioning

confidence: 99%

Probiotic Therapy as a Novel Approach for Allergic Disease

Toh¹,

Anzela²,

Tang³

et al. 2012

Front. Pharmacol.

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The prevalence of allergic disease has increased dramatically in Western countries over the past few decades. The hygiene hypothesis, whereby reduced exposure to microbial stimuli in early life programs the immune system toward a Th2-type allergic response, is suggested to be a major mechanism to explain this phenomenon in developed populations. Such microbial exposures are recognized to be critical regulators of intestinal microbiota development. Furthermore, intestinal microbiota has an important role in signaling to the developing mucosal immune system. Intestinal dysbiosis has been shown to precede the onset of clinical allergy, possibly through altered immune regulation. Existing treatments for allergic diseases such as eczema, asthma, and food allergy are limited and so the focus has been to identify alternative treatment or preventive strategies. Over the past 10 years, a number of clinical studies have investigated the potential of probiotic bacteria to ameliorate the pathological features of allergic disease. This novel approach has stemmed from numerous data reporting the pleiotropic effects of probiotics that include immunomodulation, restoration of intestinal dysbiosis as well as maintaining epithelial barrier integrity. In this mini-review, the emerging role of probiotics in the prevention and/or treatment of allergic disease are discussed with a focus on the evidence from animal and human studies.

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Probiotics: multifarious oral vaccine against infectious traumas

Cited by 41 publications

References 63 publications

Lactobacillus acidophilus ATCC 4356 inhibits biofilm formation by C. albicans and attenuates the experimental candidiasis in Galleria mellonella

Lactobacillus acidophilus ATCC 4356 inhibits biofilm formation by C. albicans and attenuates the experimental candidiasis in Galleria mellonella

Functionality and Therapeutic Values of Fermented Foods

Probiotic Therapy as a Novel Approach for Allergic Disease

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