Immunostimulatory effect of β-cryptoxanthin in vitro and in vivo

Nishi, Kosuke; Muranaka, Ayako; Nishimoto, Sogo; Kadota, Ayumu; Sugahara, Takuya

doi:10.1016/j.jff.2012.04.001

Cited by 21 publications

(9 citation statements)

References 31 publications

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“…Nishi et al . reported βCr administration causes an increase in IL‐6 levels but does not affect IL‐4 and IFN‐γ levels, indicating the significant enhancement of immunoglobulin levels and CD4 + cells count (Nishi et al ., ). Oxygenated carotenoids like βCr can be esterified with various fatty acid chains and the esterified form of this xanthophyll has a higher bioavailability than its free form (Fu et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Carotenoids: biochemistry, pharmacology and treatment

Milani

Basirnejad

Shahbazi

et al. 2016

British J Pharmacology

557

376

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*Joint first authors.Carotenoids and retinoids have several similar biological activities such as antioxidant properties, the inhibition of malignant tumour growth and the induction of apoptosis. Supplementation with carotenoids can affect cell growth and modulate gene expression and immune responses. Epidemiological studies have shown a correlation between a high carotenoid intake in the diet with a reduced risk of breast, cervical, ovarian, colorectal cancers, and cardiovascular and eye diseases. Cancer chemoprevention by dietary carotenoids involves several mechanisms, including effects on gap junctional intercellular communication, growth factor signalling, cell cycle progression, differentiation-related proteins, retinoid-like receptors, antioxidant response element, nuclear receptors, AP-1 transcriptional complex, the Wnt/β-catenin pathway and inflammatory cytokines. Moreover, carotenoids can stimulate the proliferation of B-and T-lymphocytes, the activity of macrophages and cytotoxic T-cells, effector T-cell function and the production of cytokines. Recently, the beneficial effects of carotenoid-rich vegetables and fruits in health and in decreasing the risk of certain diseases has been attributed to the major carotenoids, β-carotene, lycopene, lutein, zeaxanthin, crocin (/crocetin) and curcumin, due to their antioxidant effects. It is thought that carotenoids act in a time-and dose-dependent manner. In this review, we briefly describe the biological and immunological activities of the main carotenoids used for the treatment of various diseases and their possible mechanisms of action.

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Section: Introductionmentioning

confidence: 97%

Carotenoids: biochemistry, pharmacology and treatment

Milani

Basirnejad

Shahbazi

et al. 2016

British J Pharmacology

557

376

View full text Add to dashboard Cite

show abstract

“…On the other hand, T cells also play an important role in the cellmediated immunity. We have focused on the foodstuffs that activate the immune system for development of functional foods (Sugahara et al 2005;Nishi et al 2011Nishi et al , 2012Morishige et al 2011;Daifuku et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory activity of Bengkoang (Pachyrhizus erosus) fiber extract in vitro and in vivo

et al. 2013

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Bengkoang (Pachyrhizus erosus (L.) Urban) is one of the most popular edible root vegetables in Indonesia. Bengkoang contains fairly large amounts of carbohydrates and crude fiber. The purpose of this research is to evaluate the immunomodulatory effect of the bengkoang fiber extract (BFE) in vitro and in vivo. BFE was prepared by heating the powder of bengkoang fiber suspended in distilled water at 121°C for 20 min. BFE facilitated IgM production by the human hybridoma cell line HB4C5 cells. In addition, production of IgM, IgG, and IgA by mouse primary splenocytes was facilitated by BFE in a dose-dependent manner. BFE also significantly facilitated production of both interleukin-5 and interleukin-10 by splenocytes. Immunoglobulin production by lymphocytes from the spleen, Peyer's patch, and mesenteric lymph node were significantly activated by oral administration of BFE to mice for 14 days. The serum immunoglobulin levels of IgG, IgM, and IgA were also significantly enhanced. Furthermore, cytokine production by lymphocytes from the spleen, Peyer's patch, and mesenteric lymph node were also facilitated by oral administration of BFE. These results suggest that BFE has positive effects on the immune system in vitro and in vivo.

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“…Uncited references Q3 370 Cheng and Breen (1991), Giusti and Wrolstad (2001), Matsu-371 moto et al (2007), Nishi et al (2012) and Pattison et al (2005).…”

mentioning

confidence: 99%