Immunostimulant Agents from Andrographis paniculata

Puri, Anju; Saxena, Richa; Kc, Saxena; Srivastava, V. M. L.; Tandon, J. S.

doi:10.1021/np50097a002

Cited by 336 publications

(205 citation statements)

References 8 publications

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“…It has been traditionally used as a remedy against diabetes (Norhaida, 1994), hypertension (Ahmad and Asmawi, 1993), inflammation (Patarapanich et al, 2007) and cobra bite (Selvanayagam et al, 1994). Extensive 46 research revealed that A. paniculata has a surprisingly broad range of pharmacological effects and some of them are extremely beneficial and include anticancer (Kumar et al, 2004), anti HIV (Chang andYeung, 1988), anti AIDS (Stephen and Comac, 2000), hepatoprotective (Handa and Sharma, 1990) and immunostimulatory (Puri et al, 1993). Other pharmacological effects include; antimalarial (Misra et al, 1992), antityphoid (Sabu, 2006), antiviral (Wiart et al, 2005), antifungal (Sabu, 2006), antibacterial (Mishra et al, 2009), antidiarrhoeal (Gupta et al, 1993), antipyretic (Vedavathy andRao, 1991), antiinflammatory (Chang andBut, 1986), antidiabetic (Zhang and Tan, 2000), antithrombotic (Yeung et al, 1987), cardiovascular Zhang, 2004), antivenom (Chang andBut, 1986), antifertility (Sakila et al, 2009) and psychopharmacological activity (Mandal et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effect of the Aqueous Leaf Extract of Andrographis paniculata Nees Against Carbon Tetrachloride – Induced Hepatotoxicity in Rats

Nasir¹,

Abubakar²,

Shehu³

et al. 2013

Nig J Bas App Sci

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Hepatoprotective effect of the aqueous leaf extract of Andrographis paniculata was investigated against CCl4 -induced hepatic injury in rats. Significant (P<0.05) increase of serum levels of alanine aminotransferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), total bilirubin (TBL), direct bilirubin (DBL), total cholesterol (CHL), triglycerides (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL) and malondialdehyde (MDA) in CCl4 intoxicated rats were restored to normal levels when treated with the extract and CCl4. Significant (P<0.05) decrease of serum levels of total protein (TP), albumin (ALB), high density lipoprotein (HDL) and reduced glutathione (GSH) in CCl4 intoxicated rats were restored to normal levels when treated with the extract and CCl4. The LD50 of the leaf extract was greater than 3000 mg/kg. The study demonstrated that A. paniculata possesses significant hepatoprotective effects and may be the source of lead compound in the management of liver diseases.

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Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effect of the Aqueous Leaf Extract of Andrographis paniculata Nees Against Carbon Tetrachloride – Induced Hepatotoxicity in Rats

Nasir¹,

Abubakar²,

Shehu³

et al. 2013

Nig J Bas App Sci

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show abstract

“…Haemagglutination antibody (HA) titre Puri et al (1993) described the method for haemagglutination antibody titre. The animals were immunized by injecting 0.1 ml of SRBC suspension containing 0.5 × 10 9 cells intra-peritoneally on day 0.…”

Section: Neutrophil Adhesion Testmentioning

confidence: 99%

Comparative phytochemical analysis andin vivoimmunomodulatory activity of various extracts ofStevia rebaudianaleaves in experimental animal model

Shukla̽

Mehta

2014

Frontiers in Life Science

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The present study was undertaken to explore the comparative phytochemical analysis and immunomodulating activities of various successively extracted leaf extracts of Stevia rebaudiana (Bertoni) in albino rats. Phytochemical screening conducted on various organic leaf extracts of S. rebaudiana revealed the presence of several biologically active molecules that include sterols, saponins, alkaloids, glycosides, phenols, tannins, flavonoids and resins. The immunomodulatory activities were determined by neutrophil adhesion test, haemagglutination antibody (HA) titre delayed type hypersensitivity (DTH) response and phagocytic activity. The response produced by oral administration of ethanolic and aqueous leaf extracts showed a significant increase in neutrophil adhesion and DTH response. The augmentation of humoral immune response to sheep red blood cells by ethanolic and aqueous extracts at 300-500 mg kg -1 was higher than when an extract dose of 200 mg kg -1 was used, as shown by a dose-related increase in antibody titres in experimental rats. This study demonstrates potent immunomodulatory activities and therapeutic potential of phytochemical compounds extracted from S. rebaudiana leaf to combat against immunological disorders.

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“…The study was conducted according to Puri et al (1993) method. Four groups of rats were used as per the treatment groups above.…”

Section: Determination Of Humoral Immune Response -Hemagglutination Amentioning

confidence: 99%

Effect of the total crude extracts of Hibiscus sabdariffa on the immune system in the Wistar albino rats

Lubega¹

2013

Afr. J. Pharm. Pharmacol.

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Medicinal herbs are commonly used worldwide as immune boosters and immunomodulators in the management of various disease conditions. Many of these herbs commonly used have not been scientifically evaluated for their immune modulating activities. The study investigated the immunomodulatory activity of the total crude leaf extract of Hibiscus sabdariffa in Wistar albino rats. It was an experimental study that was conducted on four groups of animals each with 6 healthy adult rats. Group I was dosed each with 1mL of normal saline. Groups II, III and IV were dosed 1mL of 125, 250 and 500 mg/Kg bwt of total crude extract, daily for 14 days respectively. On the 15 th day, whole blood was collected into a clean ethlenediaminetetracetic acid (EDTA)-vacutainer. The complete blood count (CBC), immune blood cell count, hemagglutination antibody (HA) titers, neutrophil adhesion and delayed-type hypersensitivity (DTH) response were determined. All the doses caused an increase in mean red blood cell (RBC) counts as compared to control group. Similarly, the mean percentage neutrophils, monocytes, basophils and eosinophils increased with dose while the opposite was true for percentage lymphocytes. The mean HA titers for the herb were higher than control though no statistical difference (p≥0.05) was observed. Similar effects were observed with neutrophil adhesions response as that of HA titers. For DTH, the highest footpad thickness (175.2% increment) was observed at a dose of 500 mg/Kg bwt after 12 h and was statistically significant (p≤0.05) as compared to control. H. sabdariffa contain compounds with immunomodulatory activity in Wistar albino rats.

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Immunostimulant Agents from Andrographis paniculata

Cited by 336 publications

References 8 publications

Hepatoprotective Effect of the Aqueous Leaf Extract of Andrographis paniculata Nees Against Carbon Tetrachloride – Induced Hepatotoxicity in Rats

Hepatoprotective Effect of the Aqueous Leaf Extract of Andrographis paniculata Nees Against Carbon Tetrachloride – Induced Hepatotoxicity in Rats

Comparative phytochemical analysis andin vivoimmunomodulatory activity of various extracts ofStevia rebaudianaleaves in experimental animal model

Effect of the total crude extracts of Hibiscus sabdariffa on the immune system in the Wistar albino rats

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