Immunosensors Based on Nanomaterials for Detection of Tumor Markers

Lai, Yuxuan; Wang, Lijun; Liu, Yuan; Yang, Gaojian; Tang, Cheng; Deng, Yan; Li, Song

doi:10.1166/jbn.2018.2505

Cited by 69 publications

(32 citation statements)

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“…2) [2,32,33]. Different biomaterials use various means and technologies to play an important role in cancer prevention [34][35][36][37][38]. To achieve precise antitumor effects, these advanced biomaterials with different functions can be used to deliver immunopharmaceuticals to organs or tissues (such as the mucosa or skin) that are rich in immune cells by different routes of administration (for instance, intranasally [39], orally [40], and subcutaneously [41]).…”

Section: Introductionmentioning

confidence: 99%

Advanced biomaterials for cancer immunotherapy

et al. 2020

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Immunotherapy, as a powerful strategy for cancer treatment, has achieved tremendous efficacy in clinical trials. Despite these advancements, there is much to do in terms of enhancing therapeutic benefits and decreasing the side effects of cancer immunotherapy. Advanced nanobiomaterials, including liposomes, polymers, and silica, play a vital role in the codelivery of drugs and immunomodulators. These nanobiomaterial-based delivery systems could effectively promote antitumor immune responses and simultaneously reduce toxic adverse effects. Furthermore, nanobiomaterials may also combine with each other or with traditional drugs via different mechanisms, thus giving rise to more accurate and efficient tumor treatment. Here, an overview of the latest advancement in these nanobiomaterials used for cancer immunotherapy is given, describing outstanding systems, including lipid-based nanoparticles, polymer-based scaffolds or micelles, inorganic nanosystems, and others.

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Section: Introductionmentioning

confidence: 99%

Advanced biomaterials for cancer immunotherapy

et al. 2020

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“…Α considerable amount of scientific effort has been put towards increasing the sensitivity of an immunosensor through the optimization of either the way the recognition elements is immobilized onto the transducer surface or the morphology of the surface itself or both. As far as the latter is concerned, carbon nanotubes, noble metal nanoparticles, polymers, quantum dots, and graphene are some of the numerous nanomaterials that have been applied in the design of an immunosensor to amplify signal detection, enrich and concentrate trace analytes, and immobilize the recognition elements with enhanced stability [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Comparative Assessment of Affinity-Based Techniques for Oriented Antibody Immobilization towards Immunosensor Performance Optimization

et al. 2019

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Immunosensor sensitivity and stability depend on a number of parameters such as the orientation, the surface density, and the antigen-binding efficiency of antibodies following their immobilization onto functionalized surfaces. A number of techniques have been developed to improve the performance of an immunosensor that targets one or both of the parameters mentioned above. Herein, two widely employed techniques are compared for the first time, which do not require any complex engineering of neither the antibodies nor the surfaces onto which the former get immobilized. To optimize the different surface functionalization protocols and compare their efficiency, a model antibody-antigen system was employed that resembles the complex matrices immunosensors are frequently faced with in real conditions. The obtained results reveal that protein A/G is much more efficient in increasing antibody loading onto the surfaces in comparison to boronate ester chemistry. Despite the fact, therefore, that both contribute towards the orientation-specific immobilization of antibodies and hence enhance their antigen-binding efficiency, it is the increased antibody surface density attained with the use of protein A/G that plays a critical role in achieving maximal antigen recognition.

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“…In this context, biosensors based on carbon nanomaterials have been extensively explored for point-of-care early diagnosis of diseases. [110] While they have been widely exploited as immunobiosensors for the detection of cancer biomarkers, [111] they have been investigated to a lower extent in the diagnosis of inflammatory and auto-immune disorders. [112] Early detection of inflammatory diseases is important for controlling the progression of the disease and it is crucial for the success of the treatment and for organism repair afterward.…”

Section: Biosensingmentioning

confidence: 99%

Carbon Nanomaterials Applied for the Treatment of Inflammatory Diseases: Preclinical Evidence

Soltani

Guo

Bianco

et al. 2020

Advanced Therapeutics

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In the last decade, graphene‐based nanomaterials and carbon dots have joined the family of carbon materials mainly composed of graphite, diamond, fullerene, and carbon nanotubes. Carbon nanomaterials have been widely exploited in various fields from electronics and materials science to nanomedicine. The studies on their effect on the immune system have revealed that they possess intrinsic anti‐inflammatory properties, reducing the production of proinflammatory cytokines and modulating immune cell maturation. In addition, their large specific surface area associated with high biocompatibility allows their use as carriers for the delivery of anti‐inflammatory agents. They can also contribute to the diagnosis of inflammatory diseases as biosensors for low‐limit detection and quantification of inflammation‐related biomarkers in body fluids and tissues allowing to monitor the concentration of drugs in urine and guide personalized drug usage. Finally, they are used as adsorbents for blood plasma purification in the clinical treatment of sepsis through efficient removal of certain cytokines. This review focuses on the intrinsic anti‐inflammatory properties of carbon nanomaterials. An overview is provided on their use as carriers of anti‐inflammatory drugs, as biosensors, and for blood purification in the context of inflammatory diseases. The potential of carbon nanomaterials for clinical translation is also critically discussed.

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Immunosensors Based on Nanomaterials for Detection of Tumor Markers

Cited by 69 publications

References 0 publications

Advanced biomaterials for cancer immunotherapy

Advanced biomaterials for cancer immunotherapy

Comparative Assessment of Affinity-Based Techniques for Oriented Antibody Immobilization towards Immunosensor Performance Optimization

Carbon Nanomaterials Applied for the Treatment of Inflammatory Diseases: Preclinical Evidence

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