Advanced biomaterials for cancer immunotherapy

Yang, Fan; Shi, Kun; Jia, Yanpeng; Hao, Ying; Peng, Jinrong; Qian, Zhiyong

doi:10.1038/s41401-020-0372-z

Cited by 73 publications

(55 citation statements)

References 267 publications

(296 reference statements)

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“…The mechanism of cancer immunotherapy is based on the therapeutic activity of the body's immune system against cancer to eradicate tumor cells (Yang et al, 2020a ). During cancer cell death, the released tumor antigens are captured by antigen-presenting cells (APCs) such as immature dendritic cells (iDC) and infiltrate tumor-draining lymph nodes (Park et al, 2018 ).…”

Section: Application Of Stimuli-triggered Metallic Nanotherapeutics Imentioning

confidence: 99%

External and Internal Stimuli-Responsive Metallic Nanotherapeutics for Enhanced Anticancer Therapy

Mohapatra

Uthaman

Park

2021

Front. Mol. Biosci.

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Therapeutic, diagnostic, and imaging approaches based on nanotechnology offer distinct advantages in cancer treatment. Various nanotherapeutics have been presented as potential alternatives to traditional anticancer therapies such as chemotherapy, radiotherapy, and surgical intervention. Notably, the advantage of nanotherapeutics is mainly attributable to their accumulation and targeting ability toward cancer cells, multiple drug-carrying abilities, combined therapies, and imaging approaches. To date, numerous nanoparticle formulations have been developed for anticancer therapy and among them, metallic nanotherapeutics reportedly demonstrate promising cancer therapeutic and diagnostic efficiencies owing to their dense surface functionalization ability, uniform size distribution, and shape-dependent optical responses, easy and cost-effective synthesis procedure, and multiple anti-cancer effects. Metallic nanotherapeutics can remodel the tumor microenvironment by changing unfavorable therapeutic conditions into therapeutically accessible ones with the help of different stimuli, including light, heat, ultrasound, an alternative magnetic field, redox, and reactive oxygen species. The combination of metallic nanotherapeutics with both external and internal stimuli can be used to trigger the on-demand release of therapeutic molecules, augmenting the therapeutic efficacies of anticancer therapies such as photothermal therapy, photodynamic therapy, magnetic hyperthermia, sonodynamic therapy, chemodynamic therapy, and immunotherapy. In this review, we have summarized the role of different metallic nanotherapeutics in anti-cancer therapy, as well as their combinational effects with multiple stimuli for enhanced anticancer therapy.

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Section: Application Of Stimuli-triggered Metallic Nanotherapeutics Imentioning

confidence: 99%

External and Internal Stimuli-Responsive Metallic Nanotherapeutics for Enhanced Anticancer Therapy

Mohapatra

Uthaman

Park

2021

Front. Mol. Biosci.

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“…44 Most commercially manufactured NPs use liabilities that focus on strategies that are entirely localized on the impact of permeability and retention effect (EPR). 21 Nevertheless, [38] Equilibrium The immune cells known as the "editor" will control further production of tumor cells [39] Escape These tumor cells may promote the recruitment of regulatory cells of the innate and the adaptive defensive cells.…”

Section: Nanoparticles In Cancer Immunotherapymentioning

confidence: 99%

Enhancing Cancer Immunotherapy Treatment Goals by Using Nanoparticle Delivery System

Muluh¹,

Chen²,

Li³

et al. 2021

IJN

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Recently, there has been an incredible increase in research about the abnormal growth of cells (neoplasm), focusing on the management, treatment and preventing reoccurrence. It has been understood that the natural defense system, composed of a variety of immune defensive cells, does not just limit its function in eliminating neoplastic cells, but also controls the growth and spread of tumor cells of different kinds to other parts of the body. Cancer immunotherapy, is a cancer treatment plan that educates the body’s defensive system to forestall, control, and eliminate tumor cells. The effectiveness of immunotherapy is achieved, to its highest efficacy, by the use of nanoparticles (NPs) for precise and timely delivery of immunotherapies to specific targeted neoplasms, with less or no harm to the healthy cells. Immunotherapies have been affirmed in clinical trials as a cancer regimen for various types of cancers, the side effects resulting from imprecise and non-targeted conveyance is well managed with the use of nanoparticles. Nonetheless, we will concentrate on enhancing cancer immunotherapy approaches by the use of nanoparticles for the productivity of antitumor immunity. Nanoparticles will be presented and utilized as an objective immunotherapy delivery system for high exactness and are thus a promising methodology for cancer treatment.

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“…However, a lot of challenges still remain to be overcome for cancer immunotherapies to be widely applied in the clinical setting, regarding their safety and effectiveness [ 8 ]. There are some immunotherapies that are administered as a large dose due to their short half-life, which can result in off-target toxicities and severe side effects (e.g., cytokine release and vascular leakage syndromes) in some patients [ 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, other small-sized NPs have been reported to accumulate in the lymphatic system and enhance the systemic spread of the NP more easily [ 17 ]. A variety of nano-based platforms with diverse physicochemical properties have been developed for cancer immunotherapies, including liposomes, polymeric NPs, and silico [ 8 , 18 , 19 , 20 ]. NPs made of polymeric micelles have been self-assembled by amphiphilic polymers, consisting of hydrophilic and hydrophobic domains [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Polymeric Micelles in Cancer Immunotherapy

et al. 2021

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Cancer immunotherapies have generated some miracles in the clinic by orchestrating our immune system to combat cancer cells. However, the safety and efficacy concerns of the systemic delivery of these immunostimulatory agents has limited their application. Nanomedicine-based delivery strategies (e.g., liposomes, polymeric nanoparticles, silico, etc.) play an essential role in improving cancer immunotherapies, either by enhancing the anti-tumor immune response, or reducing their systemic adverse effects. The versatility of working with biocompatible polymers helps these polymeric nanoparticles stand out as a key carrier to improve bioavailability and achieve specific delivery at the site of action. This review provides a summary of the latest advancements in the use of polymeric micelles for cancer immunotherapy, including their application in delivering immunological checkpoint inhibitors, immunostimulatory molecules, engineered T cells, and cancer vaccines.

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Advanced biomaterials for cancer immunotherapy

Cited by 73 publications

References 267 publications

External and Internal Stimuli-Responsive Metallic Nanotherapeutics for Enhanced Anticancer Therapy

External and Internal Stimuli-Responsive Metallic Nanotherapeutics for Enhanced Anticancer Therapy

Enhancing Cancer Immunotherapy Treatment Goals by Using Nanoparticle Delivery System

Polymeric Micelles in Cancer Immunotherapy

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