Enhancing Cancer Immunotherapy Treatment Goals by Using Nanoparticle Delivery System

Muluh, Tobias Achu; Chen, Zhuo; Li, Yi; Xiong, Kang; Jin, Jing; Shao, Fu; Wu, Jingbo

doi:10.2147/ijn.s295300

Cited by 23 publications

(12 citation statements)

References 132 publications

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“…Thus, to achieve an effective outcome, the delivery system must be modified so that the immunotherapeutic carrier enters the intracellular space before accomplishing the immunotherapy. There are several types of nanoparticles, which are classified based on their size, morphology, and physical and chemical properties[ 56 ]. Nanotechnology, specifically nanoparticles as drug delivery systems (DDSs), eases targeted medicines and theragnostics.…”

Section: Types Of Cancer Nanomedicinesmentioning

confidence: 99%

Nanomedicine approaches for treatment of hematologic and oncologic malignancies

Nteli¹,

Bajwa²,

Politakis³

et al. 2022

WJCO

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Cancer is a leading cause of death worldwide. Nowadays, the therapies are inadequate and spur demand for improved technologies. Rapid growth in nanotechnology and novel nanomedicine products represents an opportunity to achieve sophisticated targeting strategies and multi-functionality. Nanomedicine is increasingly used to develop new cancer diagnosis and treatment methods since this technology can modulate the biodistribution and the target site accumulation of chemotherapeutic drugs, thereby reducing their toxicity. Cancer nanotechnology and cancer immunotherapy are two parallel themes that have emerged over the last few decades while searching for a cure for cancer. Immunotherapy is revolutionizing cancer treatment, as it can achieve unprecedented responses in advanced-stage patients, including complete cures and long-term survival. A deeper understanding of the human immune system allows the establishment of combination regimens in which immunotherapy is combined with other treatment modalities (as in the case of the nanodrug Ferumoxytol). Furthermore, the combination of gene therapy approaches with nanotechnology that aims to silence or express cancer-relevant genes via one-time treatment is gradually progressing from bench to bedside. The most common example includes lipid-based nanoparticles that target VEGF-Α and KRAS pathways. This review focuses on nanoparticle-based platforms utilized in recent advances aiming to increase the efficacy of currently available cancer therapies. The insights provided and the evidence obtained in this paper indicate a bright future ahead for immuno-oncology applications of engineering nanomedicines.

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Section: Types Of Cancer Nanomedicinesmentioning

confidence: 99%

Nanomedicine approaches for treatment of hematologic and oncologic malignancies

Nteli¹,

Bajwa²,

Politakis³

et al. 2022

WJCO

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“…Pathological inflammation, cell proliferation, migration and apoptosis of EC, VSMCs and macrophages is the hallmark of atherosclerosis pathogenesis, including several CVDs. 115 Piezo1 is necessary for sensing and transduction of various mechanical forces including shear stress, pressure, and cyclic stretch. VSMCs proliferation was reported to be increased by cyclic stretch in vitro .…”

Section: Piezo1 Correlation With Inflammation and Atherosclerosismentioning

confidence: 99%

Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis

Shinge¹,

Zhang²,

Muluh³

et al. 2021

JIR

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Recently, more and more works have focused and used extensive resources on atherosclerosis research, which is one of the major causes of death globally. Alongside traditional risk factors, such as hyperlipidemia, smoking, hypertension, obesity, and diabetes, mechanical forces, including shear stress, pressure and stretches exerted on endothelial cells by flow, is proved to be crucial in atherosclerosis development. Studies have recognized the mechanosensitive Piezo1 channel as a special sensor and transducer of various mechanical forces into biochemical signals, and recent studies report its role in atherosclerosis through different mechanical forces in pressure, stretching and turbulent shear stress. Based on our expertise in this field and considering the recent advancement of atherosclerosis research, we will be focusing on the function of Piezo1 and its involvement in various cellular mechanisms and consequent involvement in the development of atherosclerosis in this review. Also, we will discuss various functions of Piezo1 involvement in atherosclerosis and come up with new mechanistic insight for future research. Based on the recent findings, we suggest Piezo1 as a valid candidate for novel therapeutic innovations, in which deep exploration and translating its findings into the clinic will be a new therapeutic strategy for cardiovascular diseases, particularly atherosclerosis.

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“…With the rapid development of nanotechnology, the clinical application of nanomaterials is also increasing (Ulbrich et al, 2016;Zang et al, 2017;Cheng et al, 2021). Due to their special physical and chemical properties, nanoparticles have significant potential therapeutic effects in tumor immunotherapy (Velpurisiva et al, 2017;Park et al, 2018;Irvine & Dane, 2020;Muluh et al, 2021). Tumor immunotherapy mainly relies on efficient drug delivery and targeted tumor therapy.…”

Section: Introductionmentioning

confidence: 99%

Light-activated nanomaterials for tumor immunotherapy

Wang

Duan²,

Xu³

et al. 2022

Front. Chem.

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Tumor immunotherapy mainly relies on activating the immune system to achieve antitumor treatment. However, the present tumor immunotherapy used in the clinic showed low treatment efficacy with high systematic toxicity. To overcome the shortcomings of traditional drugs for immunotherapy, a series of antitumor immunotherapies based on nanomaterials have been developed to enhance the body’s antitumor immune response and reduce systematic toxicity. Due to the noninvasiveness, remote controllability, and high temporal and spatial resolution of light, photocontrolled nanomaterials irradiated by excitation light have been widely used in drug delivery and photocontrolled switching. This review aims to highlight recent advances in antitumor immunotherapy based on photocontrolled nanomaterials. We emphasized the advantages of nanocomposites for antitumor immunotherapy and highlighted the latest progress of antitumor immunotherapy based on photoactivated nanomaterials. Finally, the challenges and future prospects of light-activated nanomaterials in antitumor immunity are discussed.

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Enhancing Cancer Immunotherapy Treatment Goals by Using Nanoparticle Delivery System

Cited by 23 publications

References 132 publications

Nanomedicine approaches for treatment of hematologic and oncologic malignancies

Nanomedicine approaches for treatment of hematologic and oncologic malignancies

Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis

Light-activated nanomaterials for tumor immunotherapy

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