Immunoprophylaxis of Salmonella Gallinarum Infection by Salmonella Enteritidis-Immune Lymphokines in Broiler Chicks

Kogut, Michael H.; Téllez, G.; McGruder, Edward D.; Hargis, Billy M.; DeLoach, John R.

doi:10.1007/978-1-4899-1828-4_64

Cited by 4 publications

(2 citation statements)

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“…Due to the prolonged recovery period of individuals afflicted by ARDS, decreases in neutrophil function contribute to overwhelming pulmonary infections so often seen (Martin et al, 1991). We presently have no definitive evidence supporting tissue damage or destruction as a result of ILK-mediated heterophil activity during the first week post-hatch (Kogut et al, 1996). Further investigations will focus on confirming these observations.…”

Section: Discussionmentioning

confidence: 85%

“…ILK is a lymphokine(s ) secreted by S. enteritidis-immune T lymphocytes which have undergone mitogenic stimulation . To date, we have no evidence of pathology induced by ILK potentiation in neonatal chicks (Kogut et al, 1996), thus suggesting that the mechanisms involved are short-lived and controlled. However, administration of ILK significantly enhanced heterophil functional efficiency during the neonatal period (Lowry et al, 1997;Genovese et al, 1998).…”

Section: Introductionmentioning

confidence: 79%

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Longevity of augmented phagocytic activity of heterophils in neonatal chickens following administration ofSalmonella enteritidis-immune lymphokines to chickens

Genovese¹,

Lowry²,

Genovese³

et al. 2000

Avian Pathology

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Previously, our laboratory reported an existing relationship between ontogenesis of heterophil activity and susceptibility to Salmonella enteritidis infection in poultry during the first week post-hatch. The prophylactic administration of S. enteritidis-immune lymphokines has been shown to enhance heterophil function in vitro and reduce S. enteritidis organ invasion in 1-day-old chicks. However, how long the heterophils remain activated is currently unknown. The objective of this research was to evaluate the duration of enhanced heterophil phagocytosis of S. enteritidis following the prophylactic administration of a single injection of S. enteritidis-immune lymphokines to neonatal chicks. Administration of S. enteritidis-immune lymphokines on the day of hatch resulted in a significant increase in heterophil phagocytic activity (P < 0.05) through day 5 post-hatch. No significant differences in phagocytic activities of heterophils from control and S. enteritidis-immune lymphokinetreated chicks was demonstrated from day 6 to 14 post-hatch. These data suggest that the administration of S. enteritidis-immune lymphokines on day of hatch potentiates heterophil phagocytic activity during a critical period of susceptibility to Salmonella infection in neonatal chicks. The immune lymphokine-induced enhancement of heterophil activity subsides by day 5 as the chick's natural defenses mature and are able to resist infections without exogenous augmentation.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 79%