Immunomodulatory Treatments for Aspirin Exacerbated Respiratory Disease

Abstract

ABSTRACT

Leukotriene Antagonists in Nasal Polyposis: A Meta-analysis and Systematic Review

“…7 This process can be inhibited either by blocking the receptor with an LT receptor antagonist, such as montelukast, or by preventing the formation of cysteinyl-LTs with a 5-lipooxygenase inhibitor, such as zileuton. LT antagonists (LTAs) have proven efficacious in chronic inflammatory conditions of the airways, including allergic rhinitis, asthma, and aspirinexacerbated respiratory disease (AERD), [8][9][10][11] all diseases that often coexist with CRSwNP. Several studies have shown positive effects of LTAs as a primary treatment for CRSwNP.…”

The use of intranasal glucocorticosteroids in the treatment of rhinosinusitis: Focus on mometasone furoate

“…У пациентов с «аспириновой триадой» (aspirin exacerbated respiratory disease) (?) применение инГКС позволяет сни-зить применение пероральных ГКС и таким образом по-высить безопасность и переносимость терапии [61]. инГКС также приобретают статус препаратов выбора при хроническом РС без полипов [39,62].…”

Treating aspirin-exacerbated respiratory disease with aspirin desensitization

“…[2][3][4][5] It's estimated that up to 45% of individuals desensitized to aspirin will have a respiratory reaction during the process. Some of the reasons for the urgency include: she has required emergent care following aspirin exposure in the past, a post-bronchodilator forced expiratory volume in the first second (FEV1) greater than 60%, but less than 70% of the patient's best, and the presence of a serious condition, in her case the basilar apex aneurysm and cerebral arterial vasospasm.…”

“…[2][3][4][5] Smoking has been shown to increase the chance of developing AERD. [2][3][4][5] Smoking has been shown to increase the chance of developing AERD.…”

“…[2][3][4][5] Smoking has been shown to increase the chance of developing AERD. [2][3][4][5][6] The pathophysiology of AERD involves an acquired alteration in the metabolism of arachidonic acid within the lipoxygenase and cyclooxygenase (COX) pathways. [2][3][4][5] Avoidance of aspirin and other NSAIDs is essential.…”