Leukotriene Antagonists in Nasal Polyposis: A Meta-analysis and Systematic Review

Wentzel, Jennifer L.; Soler, Zachary M.; DeYoung, Kristen; Nguyen, Shaun A.; Lohia, Shivangi; Schlosser, Rodney J.

doi:10.2500/ajra.2013.27.3976

Cited by 65 publications

(56 citation statements)

References 38 publications

(108 reference statements)

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“…Because of the known increase in cysLT activity in CRSwNP, anti-LT therapy has been used in CRSwNP. Few studies have examined the effectiveness of anti-LT therapy in CRSwNP and these were recently summarized by Wentzel et al 1041 and Smith and Sautter. 1042 Wentzel et al 1041 performed a systematic review and meta-analysis and found 12 studies that examined the effectiveness of anti-LT therapy in CRSwNP: 5 RCTs and 7 case series.…”

Section: Viiie9 Crswnp Management: Anti-lt Therapymentioning

confidence: 99%

“…Few studies have examined the effectiveness of anti-LT therapy in CRSwNP and these were recently summarized by Wentzel et al 1041 and Smith and Sautter. 1042 Wentzel et al 1041 performed a systematic review and meta-analysis and found 12 studies that examined the effectiveness of anti-LT therapy in CRSwNP: 5 RCTs and 7 case series. Of the 5 RCTs, which included a total of 179 patients, 2 RCTs compared montelukast, a CysLT receptor antagonist, to placebo 1043,1044 ; 2 compared montelukast to INCS 1045,1046 ; and 1 compared montelukast and INCS to INCS alone following a course of oral corticosteroids.…”

Section: Viiie9 Crswnp Management: Anti-lt Therapymentioning

confidence: 99%

“…Of the 5 RCTs, which included a total of 179 patients, 2 RCTs compared montelukast, a CysLT receptor antagonist, to placebo 1043,1044 ; 2 compared montelukast to INCS 1045,1046 ; and 1 compared montelukast and INCS to INCS alone following a course of oral corticosteroids. 1047 Wentzel et al 1041 were able to combine 2 of the RCTs into a meta-analysis. Their systematic review and meta-analysis found that anti-LT therapy showed improvement in symptoms over placebo, but no difference compared to INCS.…”

Section: Viiie9 Crswnp Management: Anti-lt Therapymentioning

confidence: 99%

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International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

Self Cite

541

877

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Section: Viiie9 Crswnp Management: Anti-lt Therapymentioning

confidence: 99%

Section: Viiie9 Crswnp Management: Anti-lt Therapymentioning

confidence: 99%

Section: Viiie9 Crswnp Management: Anti-lt Therapymentioning

confidence: 99%

See 1 more Smart Citation

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

Self Cite

541

877

View full text Add to dashboard Cite

show abstract

“…This study was planned as the recommendation of the metaanalysis performed by Wentzel et al, They had recommended a study about the effect of the montelukast together with steroid spray [8]. In our study, both the case and control groups demonstrated significant improvement in the symptoms and endoscopy findings but there was no statistically significant difference between the two groups.…”

Section: Discussionmentioning

confidence: 43%

“…Due to complications of the corticosteroids, alternative treatments are studied, including leukotriene antagonists such as zafirlukast, montelukast, and zileuton. It is documented that these drugs can be used in patients who do not tolerate postoperative nasal steroids [8].…”

Section: Introductionmentioning

confidence: 99%