Immunomodulatory Effects of Supplementation with Extracts from the Marine Brown Alga Eisenia bicyclis on Macrophages

Namkoong, Seung; Kang, Se‐Chan; Hang, Do; Jang, Ki‐Hyo; Jang, Seon‐A; Choung, Myoung-Gun; Sohn, Eun‐Hwa

doi:10.7732/kjpr.2011.24.3.298

Cited by 3 publications

(3 citation statements)

References 20 publications

(18 reference statements)

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“…The challenge of experimental animals or isolated cells with lipopolysaccharide (LPS) is a common model of acute inflammation, mimicking the response to bacterial infection. A 5-week treatment of rats with Eisenia (= Ecklonia ) bicyclis extract mediated a reduced inflammatory activation of peritoneal macrophages upon in vitro LPS stimulation through inhibition of NF-κB activity [ 21 ]. This was associated with reduced iNOS expression and nitric oxide (NO) production.…”

Section: Whole Seaweed or Crude Extract Supplementationmentioning

confidence: 99%

Brown Seaweed Food Supplementation: Effects on Allergy and Inflammation and Its Consequences

Olsthoorn

Wang

Tillema³

et al. 2021

Nutrients

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Multiple health benefits have been ascribed to brown seaweeds that are used traditionally as dietary component mostly in Asia. This systematic review summarizes information on the impact of brown seaweeds or components on inflammation, and inflammation-related pathologies, such as allergies, diabetes mellitus and obesity. We focus on oral supplementation thus intending the use of brown seaweeds as food additives. Despite the great diversity of experimental systems in which distinct species and compounds were tested for their effects on inflammation and immunity, a remarkably homogeneous picture arises. The predominant effects of consumption of brown seaweeds or compounds can be classified into three categories: (1) inhibition of reactive oxygen species, known to be important drivers of inflammation; (2) regulation, i.e., in most cases inhibition of proinflammatory NF-κB signaling; (3) modulation of adaptive immune responses, in particular by interfering with T-helper cell polarization. Over the last decades, several inflammation-related diseases have increased substantially. These include allergies and autoimmune diseases as well as morbidities associated with lifestyle and aging. In this light, further development of brown seaweeds and seaweed compounds as functional foods and nutriceuticals might contribute to combat these challenges.

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Section: Whole Seaweed or Crude Extract Supplementationmentioning

confidence: 99%

Brown Seaweed Food Supplementation: Effects on Allergy and Inflammation and Its Consequences

Olsthoorn

Wang

Tillema³

et al. 2021

Nutrients

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“…Los resultados coinciden con los encontrados por Jiang et al (2013) quienes trabajaron con polisacáridos sulfatados de Ascophyllum nodosum y demostraron la producción de especies reactivas de oxígeno en células RAW 264.7. La inhibición en la producción de anión superóxido implica una fuerte actividad antioxidante de los fucoidanos sobre ROS (So et al 2007), en ese sentido otros autores han demostrado que empleando el extracto de Eisenia bicyclis y nanopartículas constituidas por quitosano y FFv se inhibe la producción de anión superóxido y la actividad fagocítica en macrófagos aislados de ratas y células RAW 264.7 respectivamente (Namkoong et al 2011, Huang & Li 2014.…”

Section: Figuraunclassified

Incremento de la viabilidad, producción de especies reactivas de oxígeno, IL-1 y TNF-α en células mononucleares de sangre periférica humana tratadas con fucoidan de Lessonia trabeculata

et al. 2019

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Las algas pardas constituyen una fuente de alto contenido de polisacáridos como los fucoidanos que poseen importantes propiedades inmunomoduladoras. El objetivo fue determinar la viabilidad de células mononucleares de sangre periférica humana (CMSPh), producción de óxido nítrico (NO), especies reactivas de oxígeno (ROS) y de las citoquinas proinflamatorias IL-1α, IL-6, TNF-α e IFN-γ en cultivos tratados con fucoidan de Lessonia trabeculata. Se empleó fucoidan de Lessonia trabeculata proveniente de la bahía San Nicolás de Marcona-Ica. Las CMSPh se aislaron empleando Ficoll-Hypaque, se distribuyeron a una concentración de 1x105 células/pocillo en medio RPMI-1640 completo y se trataron con diferentes concentraciones de fucoidan durante 24 y 48 h. La actividad citotóxica se determinó por la reducción de MTT, la producción de NO por la reacción de Griess y las ROS por la reducción del NBT. La producción de citoquinas se cuantificó por ELISA. El fucoidan de L. trabeculata estimuló la proliferación de CMSPh y produjo el incremento de ROS a concentraciones de 100-2000 μg/mL respecto al control (p<0.001), la reacción para nitritos resultó negativa. El fucoidan incrementó la producción de IL-1α y TNF-α a concentraciones de 100 y 10 μg/mL respectivamente, mientras que la producción de IL-6 e IFN-γ no mostró diferencias significativas. Se concluye que el fucoidan de L. trabeculata estimula la proliferación de CMSPh, producción de especies reactivas de oxígeno y las citoquinas proinflamatorias IL-1α y TNF-α que poseen importantes propiedades inmunomoduladoras.

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“…They also contain the storage polysaccharide laminarin, alginate, fucoxanthin and fucoidan with immunological activities (Joe et al, 2006). It has been also known that brown algae extracts closely linked to its protective properties against free radical attack and have anti-oxidant, immunomodulatory effects (Hu et al, 2010;Kang et al, 2004;Namkoong et al, 2011) and numerous studies have shown that fucoxanthin has considerable potential and promising applications in human health (Peng Fig. 1.…”

Section: Introductionmentioning

confidence: 99%

Suppressive Effects of Fucoxanthin on Degranulation in IgE-antigen complex-stimulated RBL-2H3 Cells

Namkoong¹,

Joo²,

Jang³

et al. 2012

Korean Journal of Plant Resources

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The marine carotenoid fucoxanthin can be found in marine brown seaweeds, macroalgae, diatoms, and microalgae, and has remarkable biological properties. Numerous studies have shown that fucoxanthin has considerable potential and promising applications in human health, but the underlying mechanisms involved in its anti-allergic activity are not fully understood. We here investigated the mechanisms by anti-allergic activity of fucoxanthin fraction from Eisenia bicyclis in immunoglobulin E-antigen complex (IgE/DNP-BSA)-stimulated RBL-2H3 mast cells. This study we found that the fucoxanthin inhibits the release of β-hexosaminidase and suppressed not only transcriptional activation of NF-κB, but also phosphorylation of ERK and JNK in IgE/DNP-BSA-treated RBL-2H3 cells. Fucoxanthin may be useful for preventing allergic diseases, including asthma and atopic dermatitis.

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Immunomodulatory Effects of Supplementation with Extracts from the Marine Brown Alga Eisenia bicyclis on Macrophages

Cited by 3 publications

References 20 publications

Brown Seaweed Food Supplementation: Effects on Allergy and Inflammation and Its Consequences

Brown Seaweed Food Supplementation: Effects on Allergy and Inflammation and Its Consequences

Incremento de la viabilidad, producción de especies reactivas de oxígeno, IL-1 y TNF-α en células mononucleares de sangre periférica humana tratadas con fucoidan de Lessonia trabeculata

Suppressive Effects of Fucoxanthin on Degranulation in IgE-antigen complex-stimulated RBL-2H3 Cells

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