Immunomodulatory Effects of Fentanyl or Dexmedetomidine Hydrochloride Infusion After Allogeneic Heart Transplantation in Mice

Chen, Weili; Jin, Ning; Lin, Yingying; Villani, Vincenzo; Shimizu, Akira; Xia, Zhao; Lu, Fangna; Li, Cheng; Chen, KeGong; Lin, Zhi; Qi, Zhongquan

doi:10.1097/aap.0000000000000747

Cited by 3 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the four groups, CD 8 + levels at each temporal point did not show degrees of statistical significance. These findings indicated the occurrence of perioperative immunosuppression in participants and were consistent with prior reports (Chen et al 2018). Dexmedetomidine combined with oxycodone alleviated immunosuppression likely by oxycodone elevating the IL-2 level, which activates and enhances immune responses, inducing Tc cell production, activating B-cell proliferation, and increasing the activity of T-cells and NK cells; at the same time, dexmedetomidine inhibited stress responses and reduced inflammation due to the peripheral immune system.…”

Section: Discussionsupporting

confidence: 90%

Effects of dexmedetomidine combined with oxycodone on sedation effect, perioperative inflammatory response and immunity

Wang¹,

Zhang²,

Wu³

et al. 2020

All Life

View full text Add to dashboard Cite

Dexmedetomidine is a novel, highly selective α2 adrenoceptor agonist, whereas oxycodone serves as a μand k-amboceptor agonist. To analyze the effects of dexmedetomidine combined with oxycodone in locally anesthetized patients undergoing transforaminal endoscopic resection of nucleus pulposus. 112 patients were evenly randomized into oxycodone group (OG), dexmedetomidine group (DG), oxycodone-dexmedetomidine combination group (ODG), and control group (CG). No significant difference among the four groups in terms of baseline information, recovery time, or atropine was found (p > 0.05). The mean arterial pressures (MAPs) and heart rates (HRs) in ODG reduced from the injection point and were dramatically lower over those in CG, and visual analog scale (VAS) scores in ODG at 1, 2, and 6 h following surgery were lower over those in other groups (p < 0.05). The combination of dexmedetomidine with oxycodone in the local anesthesia during analgesia and sedation of patients undergoing transforaminal endoscopic resection of the nucleus pulposus manifested tangible effects. Specifically, such improved perioperative inflammatory responses and controlled cellular immunity without promoting the onset of adverse reactions.

show abstract

Section: Discussionsupporting

confidence: 90%

Effects of dexmedetomidine combined with oxycodone on sedation effect, perioperative inflammatory response and immunity

Wang¹,

Zhang²,

Wu³

et al. 2020

All Life

View full text Add to dashboard Cite

show abstract

“…Hearts from BALB/c mice were transplanted into the neck vessels of all recipients using a non-suture cuff technique 64 . Vascularized heterotopic transplantation of the cardiac allografts was performed using microsurgical techniques.…”

Section: Methodsmentioning

confidence: 99%

“…After a supraclavicular incision of the recipient mouse, the internal carotid artery and vena jugularis externa cava were clamped. The ascending aorta and pulmonary artery of the donor’s heart were attached to the cannulated internal carotid artery and vena jugularis externa of the recipient mouse using a non-suture cuff technique 64 . Beating of the transplanted heart was observed upon removal of the cross-clamp, and the incision was closed.…”

Section: Methodsmentioning

confidence: 99%

Disulfiram treatment suppresses antibody-producing reactions by inhibiting macrophage activation and B cell pyrimidine metabolism

Chen,

Toda,

Takeuchi

et al. 2024

Commun Biol

View full text Add to dashboard Cite

Antibody responses, involving B cells, CD4 + T cells, and macrophages, are implicated in autoimmune diseases and organ transplant rejection. We have previously shown that inhibiting FROUNT with disulfiram (DSF) suppresses macrophage activation and migration, effectively treating inflammatory diseases. In this study, we investigated the effectiveness of DSF in antibody-producing reactions. Using a heart transplantation mouse model with antibody-mediated rejection, we administered anti-CD8 antibody to exclude cellular rejection. DSF directly inhibited B cell responses in vitro and significantly reduced plasma donor-specific antibodies and graft antibody deposition in vivo, resulting in prolonged survival of the heart graft. DSF also mediated various effects, including decreased macrophage infiltration and increased Foxp3+ regulatory T-cells in the grafts. Additionally, DSF inhibited pyrimidine metabolism-related gene expression induced by B-cell stimulation. These findings demonstrate that DSF modulates antibody production in the immune response complexity by regulating B-cell and macrophage responses.

show abstract

Immunomodulatory effects of fentanyl and morphine on DSS- and TNBS-induced colitis

Wang

et al. 2022

Immunopharmacology and Immunotoxicology

View full text Add to dashboard Cite

Immunomodulatory Effects of Fentanyl or Dexmedetomidine Hydrochloride Infusion After Allogeneic Heart Transplantation in Mice

Abstract: These data suggest that both Dex and Fen have immunomodulatory properties in the induction period following transplantation.

Cited by 3 publications

References 22 publications

Effects of dexmedetomidine combined with oxycodone on sedation effect, perioperative inflammatory response and immunity

Effects of dexmedetomidine combined with oxycodone on sedation effect, perioperative inflammatory response and immunity

Disulfiram treatment suppresses antibody-producing reactions by inhibiting macrophage activation and B cell pyrimidine metabolism

Immunomodulatory effects of fentanyl and morphine on DSS- and TNBS-induced colitis

Contact Info

Product

Resources

About