Immunomodulatory effects of Bifidobacterium bifidum 231 on trinitrobenzenesulfonic acid-induced ulcerative colitis in rats

Kumar, C. S. V. Satish; Reddy, K. Kondal; Boobalan, G.; Reddy, A Gopala; Chowdhary, CH Sudha Rani; Vinoth, A.; Jayakanth, K.; Rao, G. Srinivasa

doi:10.1016/j.rvsc.2016.10.010

Cited by 18 publications

(5 citation statements)

References 25 publications

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“…Among the group of rats with colitis and supplemented with Bifidobacterium infantis , researchers noted a reduction in symptoms, weaker damage to the mucosal architecture, which indicated the protective meaning of probiotics for mucus goblet cells and the epithelial cell layer. In the murine model of TNBS colitis, oral supplementation with Bifidobacterium bifidum reduced the course of the disease on issues of colonic edema, macroscopic damage, histological scores, and additionally seemed to prevent weight-loss [ 76 , 77 ]. Based on another research group, supplementation with Bifidobacterium bifidum significantly increased the level of IL-10 and reduced the level of IL-1β in the colon sections, which confirmed the anti-inflammatory effect [ 77 ].…”

Section: Probiotics Treatment and Protection From Ibdmentioning

confidence: 99%

“…In the murine model of TNBS colitis, oral supplementation with Bifidobacterium bifidum reduced the course of the disease on issues of colonic edema, macroscopic damage, histological scores, and additionally seemed to prevent weight-loss [ 76 , 77 ]. Based on another research group, supplementation with Bifidobacterium bifidum significantly increased the level of IL-10 and reduced the level of IL-1β in the colon sections, which confirmed the anti-inflammatory effect [ 77 ]. Those findings seem to confirm that Bifidobacterium infantis and Bifidobacterium bifidum have modulatory properties, and reduce the inflammation as well as the clinical symptoms of colitis.…”

Section: Probiotics Treatment and Protection From Ibdmentioning

confidence: 99%

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The Effectiveness of Probiotics in the Treatment of Inflammatory Bowel Disease (IBD)—A Critical Review

2020

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Inflammatory bowel disease (IBD), which affects millions of people worldwide, includes two separate diseases: Crohn’s disease (CD) and ulcerative colitis (UC). Although the background (chronic inflammatory state) and some of the symptoms of CD and UC are similar, both diseases differ from each other. It is becoming clear that a combination of many factors, in particular genetic background, host immune response and microbial reduced diversity status are associated with IBD. One potential strategy to prevent/treat IBD is gut modulation by probiotics. Over the last twenty years, many publications have focused on the role of probiotics in the course of IBD. The review discusses the utility of different strains of probiotics, especially Bifidobacterium spp., in all factors potentially involved in the etiology of IBD. The probiotic modulatory properties among different study models (cell lines, animal models of colitis, clinical study) are discussed and probiotic usefulness is assessed in relation to the treatment, prevention, and remission of diseases.

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Section: Probiotics Treatment and Protection From Ibdmentioning

confidence: 99%

Section: Probiotics Treatment and Protection From Ibdmentioning

confidence: 99%

The Effectiveness of Probiotics in the Treatment of Inflammatory Bowel Disease (IBD)—A Critical Review

2020

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“…Reportedly, Bifidobacterium adolescentis IM38 alleviated inflammation by downregulating NF-κB expression and lipopolysaccharide production in high-fat diet-induced ulcerative colitis in mice[ 40 ]. An in vitro and in vivo study suggested that Bifidobacteria bifidum 231 enhanced the IL-10 production in IEC-6 cell lines and improved the macroscopic and histological conditions in TNBS-induced colitis[ 41 ]. Bifidobacterium longum CCM7952 strengthened the epithelial barrier function and reduced clinical symptoms in experimental colitis[ 31 ].…”

Section: Diets and Dietary Interventions For Ibdmentioning

confidence: 99%

Diets, functional foods, and nutraceuticals as alternative therapies for inflammatory bowel disease: Present status and future trends

Mijan

Lim

2018

WJG

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Inflammatory bowel disease (IBD) is a serious health concern among western societies. The disease is also on the rise in some East Asian countries and in Australia. Health professionals and dietitians around the world are facing an unprecedented challenge to prevent and control the increasing prevalence of IBD. The current therapeutic strategy that includes drugs and biological treatments is inefficient and are associated with adverse health consequences. In this context, the use of natural products is gaining worldwide attention. In vivo studies and clinical evidence suggest that well-planned dietary regimens with specific nutrients can alleviate gastrointestinal inflammation by modulating inflammatory cytokines, such as tumor necrosis factor α (TNF-α), interleukin 1 (IL-1), IL-6, IL-1β, and IL-10. Alternatively, the avoidance of high-fat and high-carbohydrate diets is regarded as an effective tool to eliminate the causes of IBD. Many functional foods and bioactive components have received attention for showing strong therapeutic effects against IBD. Both animal and human studies suggest that bioactive functional foods can ameliorate IBD by downregulating the pro-inflammatory signaling pathways, such as nuclear factor κB, STAT1, STAT6, and pro-inflammatory cytokines, including IL-1β, IL-4, IL-6, COX-2, TNF-α, and interferon γ. Therefore, functional foods and diets have the potential to alleviate IBD by modulating the underlying pathogenic mechanisms. Future comprehensive studies are needed to corroborate the potential roles of functional foods and diets in the prevention and control of IBD.

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“…Bifidobacterium is a common gram‐positive anaerobic probiotic that mainly ferments glucose into lactic acid and acetic acid via the 6‐phosphate fructose pathway, which is characterized by the presence of fructose 6‐phosphate phosphoketolase (Pokusaeva et al., 2011). Furthermore, it can release bacteriocin, adhere to the intestinal epithelium, and strengthen the intestinal epithelial barrier to reduce gastrointestinal diseases (Wong et al., 2019) and regulate immunity (Satish Kumar et al., 2017).…”

Section: Resultsmentioning

confidence: 99%

Differences in the gut microbiota composition of rats fed with soybean protein and their derived peptides

Zhang

et al. 2021

Journal of Food Science

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Current studies regarding the effect of different nitrogen sources on gut microbiota have thus far disregarded the ability of probiotics and coliforms to compete for protein. This study aimed to investigate the differences in the utilization of soybean protein (SPro) and its derived peptides (SPep) by the gut microbiota of Sprague Dawley (SD) rats. The SPro and SPep prepared in this study showed extensive SPro molecular weight distribution, while that of SPep was minimal, ranging between 150 and 1000 Da and primarily consisting of two to five amino acids. The cecum microflora composition of the rats was determined via 16S rDNA amplicon sequencing, showing that the SPro and SPep significantly increased the abundance and uniformity of the gut microbiota after 35 days of feeding. The Firmicutes/Bacteroidetes (F/B) ratios of the SPep, SPro, and casein groups were 2.49 ± 0.60, 2.98 ± 1.12, and 2.59 ± 0.74, respectively. Although the rats fed with SPro and SPep displayed similar gut microbiome structures, SPep significantly promoted Lactobacillus and Phascolarctobacterium growth. The results showed that SPep significantly increased the diversity of the gut microbiota and elevated the probiotic proportion. Practical Application SPro and SPep are two nutritious and high‐quality nitrogen sources. The results showed that SPro and SPep regulated the structure of gut microbiota in rats, and the effect of SPep was better. This study provides a theoretical basis for developing SPep functional foods able to regulate gut microbiota and maintain health.

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Immunomodulatory effects of Bifidobacterium bifidum 231 on trinitrobenzenesulfonic acid-induced ulcerative colitis in rats

Cited by 18 publications

References 25 publications

The Effectiveness of Probiotics in the Treatment of Inflammatory Bowel Disease (IBD)—A Critical Review

The Effectiveness of Probiotics in the Treatment of Inflammatory Bowel Disease (IBD)—A Critical Review

Diets, functional foods, and nutraceuticals as alternative therapies for inflammatory bowel disease: Present status and future trends

Differences in the gut microbiota composition of rats fed with soybean protein and their derived peptides

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