Immunomodulatory; Anti-inflammatory/antioxidant Effects of Polyphenols: A Comparative Review on the Parental Compounds and Their Metabolites

Sobhani, Mahsa; Farzaei, Mohammad Hosein; Kiani, Sarah; Khodarahmi, Reza

doi:10.1080/87559129.2020.1717523

Cited by 70 publications

(44 citation statements)

References 243 publications

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“…Dietary polyphenols have been reported to have various biological activities including polyphenols, which have immunomodulatory, antioxidant, anti-inflammatory, antiallergic antimicrobial, ant-mutagenic, and detoxification activities (152). Recent studies showed that polyphenols can modulate the immune functions through binding to cellular receptors and altering the cell pathways, thereby regulating the host immune response (153). For instance, curcumin and resveratrol have been evidenced to inhibit the signaling pathway of nuclear factor-kappa β (NF-κβ) and thereby inhibit the release of the proinflammatory cytokine TNF-α (154).…”

Section: Phytogenic Feed Additivesmentioning

confidence: 99%

The Strategy of Boosting the Immune System Under the COVID-19 Pandemic

et al. 2021

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The novel coronavirus (SARS-CoV-2) infection (COVID-19) has raised considerable concern on the entire planet. On March 11, 2020, COVID-19 was categorized by the World Health Organization (WHO) as a pandemic infection, and by March 18, 2020, it has spread to 146 countries. The first internal defense line against numerous diseases is personalized immunity. Although it cannot be claimed that personalized nutrition will have an immediate impact on a global pandemic, as the nutritional interventions required a long time to induce beneficial outcomes on immunity development, nutritional strategies are still able to clarify and have a beneficial influence on the interplay between physiology and diet, which could make a positive contribution to the condition in the next period. As such, a specific goal for every practitioner is to evaluate different tests to perceive the status of the patient, such as markers of inflammation, insulin regulation, and nutrient status, and to detect possible imbalances or deficiencies. During the process of disease development, the supplementation and addition of different nutrients and nutraceuticals can influence not only the viral replication but also the cellular mechanisms. It is essential to understand that every patient has its individual needs. Even though many nutrients, nutraceuticals, and drugs have beneficial effects on the immune response and can prevent or ameliorate viral infections, it is essential to detect at what stage in COVID-19 progression the patient is at the moment and decide what kind of nutrition intervention is necessary. Furthermore, understanding the pathogenesis of coronavirus infection is critical to make proper recommendations.

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Section: Phytogenic Feed Additivesmentioning

confidence: 99%

The Strategy of Boosting the Immune System Under the COVID-19 Pandemic

et al. 2021

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“…Dietary polyphenols present promising immunotherapy due to their biological multi‐functions. Recent investigations revealed that the function of immune cells is modulated by each type of polyphenol by binding to cellular receptors and altering signalling pathways of the cell and thus regulating the immune response of the host (Sobhani et al., 2020). For instance, evidence from recent studies reported that for instance resveratrol and curcumin could inhibit releasing of the pro‐inflammatory cytokine tumour necrosis factor (TNF‐α) via inhibiting the signalling pathway of nuclear factor‐kappa β (NF‐κβ; Joe et al., 2004; Kim, Yoo et al, 2011; Liang et al., 2019).…”

Section: Immunostimulatory Role Of Dietary Polyphenolsmentioning

confidence: 99%

The role of polyphenols in poultry nutrition

Abdel-Moneim

Shehata

Alzahrani

et al. 2020

Animal Physiology Nutrition

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The increased awareness regarding the quality and safety of poultry products and related health properties, in addition to the prohibition of antibiotic growth promoters from the European Union markets have raised attention of producers to plant-based feed additives as unconventional alternatives. Phytogenic feed supplements, such as spices, intact herbs and their extracts, prebiotics, probiotics, and essential oils are the conventional alternatives of antibiotic growth promoters in poultry production sector (Abd

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“…The organic acids were mainly lactic acid, malic acid, acetic acid, and citric acid. Rich phytochemicals, such as polyphenols, flavonoids, and tannins grant noni wine a strong antioxidant effect (Sobhani, Farzaei, Kiani, & Khodarahmi, 2020). In this study, noni wine was supplemented to HFD‐fed C57BL/6J mice, resulting in the improved expression of both antioxidant‐ and lipid metabolism‐related genes.…”

Section: Discussionmentioning

confidence: 99%