The increased awareness regarding the quality and safety of poultry products and related health properties, in addition to the prohibition of antibiotic growth promoters from the European Union markets have raised attention of producers to plant-based feed additives as unconventional alternatives. Phytogenic feed supplements, such as spices, intact herbs and their extracts, prebiotics, probiotics, and essential oils are the conventional alternatives of antibiotic growth promoters in poultry production sector (Abd
Highlights
Biological ZnONPs have considerable bactericidal against pathogenic fish bacteria.
Biological ZnONPs reduced the bacterial load in water and fish tissues.
Biological ZnONPs enhanced FCR feeding and swimming behaviors.
Biological ZnONPs stimulated fish health and production.
An organometallic azomethine ferrocenyl ligand (FCAP) and its transition metal complexes ([M (FCAP)2], where M = VO2+, Mn2+ cations, and [M (FCAP) (CH3COO− or NO3−)], where M = Zn2+ and Pd2+ cations) were prepared. Their structures were confirmed via various spectral and physicochemical studies performed. The crystallinity of the investigated metal chelates was confirmed by X‐ray diffraction data. The spectral data of the FCAP azomethine ligand and its metal chelates were explained concerning the structural changes due to complex formation. From the electronic spectra and the magnetic moments, the information about geometric structures can be concluded. The activation thermodynamic parameters of the thermal degradation for FCAP complexes were calculated utilizing the method of Coats–Redfern. in vitro antimicrobial, anticancer, and antioxidant activities of FCAP azomethine ligand and its complexes were screened. All the investigated metal chelates exhibited superiority on the free FCAP ligand in successful treatment. Moreover, the binding nature of the investigated complexes with calf thymus DNA (ctDNA) was examined by various methods such as spectrophotometry, viscosity, and, gel electrophoresis. Their binding feature to ctDNA was proposed to be electrostatic, intercalation, or replacement mode. Furthermore, molecular docking inspection has been conducted to clarify the nature of the binding and binding affinity of protein synthesized compounds (PDB:3hb5).
Proceeding from the view concerning the environmental safety, the green synthesis approach was implemented in this study to synthesize new Schiff base complexes. All compounds were characterized by spectroscopic, analytical and theoretical techniques. Octahedral configuration was proposed for all complexes except Pd(II) one which has square‐planer geometry. The ligand coordinated towards metal ions through bi‐dentate or tri‐dentate in mono‐negative or neutral state. DFT method in material studio package, was used to optimize structural forms for most compounds. Conductometric titrations were carried out for Cu(II) and Ni(II) ions to estimate association and formation constants in solutions at presence or absence of H2L ligand. Hirshfeld surface properties were estimated by using Crystal explorer 3.1 program. The data proposed well molecular packing in crystal systems of Pd(II) and Co(II) complexes. Drug‐likeness study as well as MOE‐docking simulation were done to put an expectation for biological efficiency, which point to the priority of the ligand and its Pd(II) and Zn(II) complexes. Prolonged biological screening was made to evaluate the effectiveness of all new compounds in comparing to standard drugs. The ligand and its Zn(II) complex were the most effective compounds towards variable microbes, free radical producers and colorectal carcinoma cells lines.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.