Immunomodulatory activity of polysaccharides isolated from Strongylocentrotus nudus eggs

Liu, Chunhui; Xi, Tao; Lin, Qing; Xing, Yingying; Liang, Y. T.; Luo, Xue‐Gang; Wang, Fengshan

doi:10.1016/j.intimp.2008.09.005

Cited by 58 publications

(38 citation statements)

References 24 publications

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“…It has been reported that activated macrophages can suppress tumor cell growth through the release of TNF-α, which is responsible for killing the cancer cells. 42) In addition, IL-6 has been regarded as a major immune mediator. 43) Therefore, these results suggested that the crude and F 2 SPs might modulate the host immune function by releasing various chemokines and/ or cytokines, and thus could be potentially applied as a therapeutic agent for cancer treatment.…”

Section: Molecular Characteristics Of Crude and Fractionated Spsmentioning

confidence: 99%

Characterization and immunomodulatory activities of polysaccharides from Spirogyra neglecta (Hassall) Kützing

Surayot

Jian-guo

Lee

et al. 2015

Bioscience, Biotechnology, and Biochemistry

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Sulfated polysaccharides (SP) isolated from freshwater green algae, Spirogyra neglecta (Hassall) Kützing, and fractionated SPs were examined to investigate their molecular characteristics and immunomodulatory activity. The crude and fractionated SPs (F1, F2, and F3) consisted mostly of carbohydrates (68.5–85.3%), uronic acids (3.2–4.9%), and sulfates (2.2–12.2%) with various amounts of proteins (2.6–17.1%). d-galactose (23.5–27.3%), d-glucose (11.5–24.8%), l-fucose (19.0–26.7%), and l-rhamnose (16.4–18.3%) were the major monosaccharide units of these SPs with different levels of l-arabinose (3.0–9.4%), d-xylose (4.6–9.8%), and d-mannose (0.4–2.3%). The SPs contained two sub-fractions with molecular weights (Mw) ranging from 164 × 103 to 1460 × 103 g/mol. The crude and fractionated SPs strongly stimulated murine macrophages, producing considerable amounts of nitric oxide and various cytokines via up-regulation of their mRNA expression by activation of nuclear factor-kappa B and mitogen-activated protein kinases pathways. The main backbone of the most immunoenhancing SP was (1→3)-l-Fucopyranoside, (1→4,6)-d-Glucopyranoside, and (1→4)-d-Galactopyranoside.

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Section: Molecular Characteristics Of Crude and Fractionated Spsmentioning

confidence: 99%

Characterization and immunomodulatory activities of polysaccharides from Spirogyra neglecta (Hassall) Kützing

Surayot

Jian-guo

Lee

et al. 2015

Bioscience, Biotechnology, and Biochemistry

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“…For example, Strongylocentrotus nudus egg polysaccharide (SEP) stimulated the proliferation of T lymphocytes in a dosedependent manner (Liu et al, 2008). Polysaccharides from Phascolosoma esulenta could significantly raise spleen and thymus indices and enhance Con Astimulated spleen cells proliferation in mice (RenJie, 2008).…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory and antioxidant activity of a Siraitia grosvenorii polysaccharide in mice

Zhang¹,

Hu²,

Lu³

2011

Afr. J. Biotechnol.

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The aim of this present study was to investigate the immunomodulatory and antioxidant activities of Siraitia grosvenorii polysaccharide (SGP) using a mouse model. The roles of regulation of SGP were investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, fluorescence method and ELISA method. The chemical structures were analyzed by Fourier transform infrared spectroscopy (FTIR) and gas chromatography (GC). The results show that SGP promoted the proliferation of spleen cells and regulated the level of reactive oxygen species (ROS) in vitro. Furthermore, it significantly raised spleen and thymus indices and superoxidase dismutase activity and regulated the cytokine levels of spleen and thymus in mice in vivo. These findings suggest that SGP possesses immunomodulatory and antioxidant effects.

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“…It has, however, been suggested that the extracts might behave as biological response modifiers, stimulating the immune system by the induction of NO or cytokine release which could suppress the growth of cancer cells. 10,27) Raw 264.7 murine macrophage cells have been known to release cytokines in response to the addition of LPS, and this system has been used to determine the modulating activities of compounds toward cytokine production. 28) The effect of the crude extract and fractions on immunomodulation was therefore determined in the current study by using Raw 264.7 cells to investigate the released amounts of NO, PGE 2 and TNF-.…”

Section: Bioactivities Of the Crude Extract And Fractionsmentioning

confidence: 99%

Molecular Characteristics of Water-Soluble Extracts fromHypsizigus marmoreusand Theirin VitroGrowth Inhibition of Various Cancer Cell Lines and Immunomodulatory Function in Raw 264.7 Cells

Bao

You

2011

Bioscience, Biotechnology, and Biochemistry

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Immunomodulatory activity of polysaccharides isolated from Strongylocentrotus nudus eggs

Cited by 58 publications

References 24 publications

Characterization and immunomodulatory activities of polysaccharides from Spirogyra neglecta (Hassall) Kützing

Characterization and immunomodulatory activities of polysaccharides from Spirogyra neglecta (Hassall) Kützing

Immunomodulatory and antioxidant activity of a Siraitia grosvenorii polysaccharide in mice

Molecular Characteristics of Water-Soluble Extracts fromHypsizigus marmoreusand Theirin VitroGrowth Inhibition of Various Cancer Cell Lines and Immunomodulatory Function in Raw 264.7 Cells

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